Role of Endotoxin and Interleukin-1 in Modulating ACTH, LH and Sex Steroid Secretion

  • C. Rivier
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 274)


There is increasing evidence that the immune and the endocrine axis are functionally connected and influence each other’s activity {review in (1)}. While the effects of hormones such as corticosteroids and endogenous opiates on immune functions have been abundantly described, the reciprocal arm of this bidirectional pathway, i.e. the influence exerted by signals from the immune system on endocrine functions, has only recently started to be investigated. It is presently believed that products of activated immune cells, such as the lymphokines, are central to this bilateral communication (2). During the early part of immune activation, in particular, stimulated macrophages produce interleukin-1 (IL-1), which can enter the circulation (3) and alter the activity of the hypothalamic-pituitary-adrenal (HPA) and/or hypothalamic-pituitary-gonadal (HPG) axis.


Newcastle Disease Virus Corticosterone Level Plasma Corticosterone ACTH Secretion Corticosterone Secretion 
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Copyright information

© Plenum Press, New York 1990

Authors and Affiliations

  • C. Rivier
    • 1
  1. 1.The Clayton Foundation Laboratories for Peptide BiologyThe Salk InstituteLa JollaUSA

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