Effects of Thyroid Hormones on the Hypothalamic Dopaminergic Neurons

  • M. J. Reymond
  • T. Lemarchand-Béraud
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 274)


On the basis of numerous studies on structural, biochemical, and functional impairments of the central nervous system in instances of fetal or neonatal thyroid deficiency (1–4), it is now acknowledged that thyroid hormones play an important role in brain development. Whereas, trophic effects of the thyroid hormones on brain morphogenesis are generally recognized during fetal and neonatal periods of life, the influence of thyroid hormones on the adult brain is less documented. Yet, functional disturbances—and to a lesser extent morphological impairments—occur in the brain of hypothyroid adult animals and humans. Most of these alterations are reversible through substitutive treatments with thyroid hormones, supportive of the view that thyroid hormones have subtle modulatory effects in the adult central nervous system: effects that may greatly differ from one brain region to another one.


Thyroid Hormone Tyrosine Hydroxylase Median Eminence Substitutive Treatment Mediobasal Hypothalamus 
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Copyright information

© Plenum Press, New York 1990

Authors and Affiliations

  • M. J. Reymond
    • 1
  • T. Lemarchand-Béraud
    • 1
  1. 1.Division of Endocrinology, Department of Internal MedicineC.H.U.V.LausanneSwitzerland

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