Skip to main content
SpringerLink
Log in

Interactions Between the Circulating Hormones Angiotensin and Atrial Natriuretic Peptide and Their Receptors in Brain

  • Chapter
Circulating Regulatory Factors and Neuroendocrine Function

Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 274))

Abstract

Angiotensin II (ANG II) and atrial natriuretic peptide (ANP) play important roles in the regulation of cardiovascular function and fluid balance (1,2). Circulating ANG II stimulates specific receptors to induce vasoconstriction, aldosterone production, vasopressin release, and sodium retention (2). There are alterations in the peripheral renin-angiotensin system in genetic and experimental hypertension (3). The renin-angiotensin system is also important in human hypertension, and blockade of the last step of ANG II formation by inhibition of the angiotensin converting enzyme (ACE) is one of the standard therapies. ANP, produced in the heart, is released to the circulation and is involved in the control of fluid volume and cardiovascular function (1). ANP metabolism is altered in hypertension (4). The peripheral effects of ANP, increased sodium and water excretion by the kidneys, decreased aldosterone production, vasodilation and antihypertensive actions are antithetical to those of the water conservation peptides, vasopressin, and ANG II (1). For these reasons peripheral ANP and ANG II are considered to be part of physiologically antagonistic regulatory systems.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Log in via an institution
Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 39.99
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 54.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. DeBold, A.J., Atrial natriuretic factor: a hormone produced by the heart, Science 230: 767–770, 1985.

    Article  CAS  Google Scholar 

  2. Vallotton, M.B., The renin-angiotensin system, Trends Pharmacol Sci 8: 69–74, 1987.

    Article  CAS  Google Scholar 

  3. Niwa, M., A. Israel, and J.M. Saavedra, Pindolol decreases plasma angiotensin-converting enzyme activity in young spontaneously hypertensive rats, Eur J Pharmacol 110: 133–136, 1985.

    Article  PubMed  CAS  Google Scholar 

  4. Morii, N., K. Nakao, M. Kihara, A. Sugawara, M. Sakamoto, Y. Yamori, and H. Imura, Decreased content in left atrium and increased plasma concentration of atrial natriuretic polypeptide in spontaneously hypertensive rats (SHR) and SHR stroke-prone, Biochem Biophys Res Commun 135: 74–81, 1986.

    Article  PubMed  CAS  Google Scholar 

  5. Phillips, M.I., Functions of angiotensin in the central nervous system, Ann Rev Physiol 49: 413–435,1987.

    Article  CAS  Google Scholar 

  6. Antunes-Rodrigues, J., S.M. McCann, and W.K. Samson, Central administration of atrial natriuretic factor inhibits saline preference in the rat, Endocrinology 118: 1726–1728, 1986.

    Article  PubMed  CAS  Google Scholar 

  7. Haskins, J.T., G. J. Zingara, and R.W. Lappe, Rat atriopeptin III alters hypothalamic neuronal activity, Neurosci Lett 67: 279–284, 1986.

    Article  PubMed  CAS  Google Scholar 

  8. Obana, K., M. Naruse, T. Inagami, A.B. Brown, K. Naruse, F. Kurimoto, H. Sakurai, H. Demura, and K. Shizune, Atrial natriuretic factor inhibits vasopressin secretion from rat posterior pituitary, Biochem Biophys Res Commun 132: 1088–1094, 1985.

    Article  PubMed  CAS  Google Scholar 

  9. Mendelsohn, FA.O., R. Quirion, J.M. Saavedra, G. Aguilera, and K. Catt, Autoradiographic localization of angiotensin II receptors in rat brain, Proc Natl Acad Sci USA 81: 1575–1579, 1984.

    Article  PubMed  CAS  Google Scholar 

  10. Quirion R., M. Dalpe, and T.V. Dam, Characterization and distribution of receptors for atrial natriuretic peptides in mammalian brain, Proc Natl Acad Sci USA 83: 174–178, 1986.

    Article  PubMed  CAS  Google Scholar 

  11. Saavedra, J.M., A. Israel, L.M. Plunkett, M. Kurihara, K. Shigematsu, and F.M.A. Correa, Quantative distribution of angiotensin II binding sites in rat brain by autoradiography, Peptides 7: 679–687,1986.

    Article  PubMed  CAS  Google Scholar 

  12. Shigematsu, K., J.M. Saavedra, L.M. Plunkett, M. Kurihara, and F.M.A. Correa, Angiotensin II binding sites in the anteroventral-third ventricle (AV3V) area and related structures of the rat brain, Neurosci Lett 67: 37–41, 1986.

    Article  PubMed  CAS  Google Scholar 

  13. Kurihara, M., J.M. Saavedra, and K. Shigematsu, Localization and characterization of atrial natriuretic peptide binding sites in discrete areas of rat brain and pituitary gland by quantitative autoradiography, Brain Res 408: 31–39, 1987.

    Article  PubMed  CAS  Google Scholar 

  14. Jacobowitz, D.M., G. Skofitsch, H.R. Keiser, R.L. Eskay, and N. Zamir, Evidence for the existence of atrial natriuretic factor-containing neurons in the rat brain, Neuroendocrinology 40: 92–94, 1985.

    Article  PubMed  CAS  Google Scholar 

  15. Nazarali, A.J., J.S. Gutkind, Fernando M.A. Correa, and J.M. Saavedra, Enalapril decreases angiotensin II receptors in subfornical organ of SHR, Am J Physiol 256: H1609–H1614, 1989.

    PubMed  CAS  Google Scholar 

  16. Kvetanský, R., V.K. Weise, and IJ. Kopin, Elevation of adrenal tyrosine hydroxylase and phenylethanol-amine-N-methyl transferase by repeated immobilization of rats, Endocrinology 87: 744–749, 1970.

    Article  Google Scholar 

  17. Israel, A., L.M. Plunkett, and J.M. Saavedra, Quantitative autoradiographic characterization of receptors for angiotensin II and other neuropeptides in individual brain nuclei and peripheral tissues from single rats, Cell Mol Neurobiol 5: 211–222, 1985.

    Article  PubMed  CAS  Google Scholar 

  18. Saavedra, J.M., F.MA. Correa, L.M. Plunkett, A. Israel, M. Kurihara, and K. Shigematsu, Binding of angiotensin and atrial natriuretic peptide in brain hypertensive rats, Nature 320: 758–760, 1986.

    Article  PubMed  CAS  Google Scholar 

  19. Nazarali, A.J., J.S. Gutkind, and J.M. Saavedra, Calibration of [125I]-polymer standards with [125I]-brain paste standards for use in quantitative receptor autoradiography, J Neurosci Methods, In Press.

    Google Scholar 

  20. Ganten, D., K. Hermann, C. Bayer, T. Unger, and R.E. Lang, Angiotensin synthesis in the brain and increased turnover in hypertensive rats, Science 221: 869–871, 1983.

    Article  PubMed  CAS  Google Scholar 

  21. Wong, M., W. K. Samson, C.A. Dudley, and R.L. Moss, Direct, neuronal action of atrial natriuretic factor in the rat brain, Neuroendocrinology 44: 49–53, 1986.

    Article  PubMed  CAS  Google Scholar 

  22. Castrén, E., and J.M. Saavedra, Repeated stress increases the density of angiotensin II binding sites in rat paraventricular nucleus and subfornical organ, Endocrinology 122: 370–372, 1988.

    Article  PubMed  Google Scholar 

  23. Swanson, L.W., and P.E. Sawchenco, Paraventricular nucleus: a site for the integration of neuroendocrine and anatomic mechanisms, Neuroendocrinology 31: 410–417, 1980.

    Article  PubMed  CAS  Google Scholar 

  24. Steardo, L., and J.A. Nathanson, Brain barrier tissues: end organs for atriopeptins, Science 235: 470–473, 1987.

    Article  PubMed  CAS  Google Scholar 

  25. Gutkind, J.S., M. Kurihara, and J.M. Saavedra, Increased angiotensin II receptors in brain nuclei of DOCA-salt hypertensive rats, Am J Physiol 255: H646–H650, 1988.

    PubMed  CAS  Google Scholar 

  26. Brody, M.J., and A.K. Johnson, Role of the anteroventral third ventricle region in fluid and electrolyte balance, arterial pressure regulation and hypertension, In W.F. Ganong and L. Martini (eds) Frontiers in Neuroendocrinology ,Raven Press, New York, Volume 6, pp. 249–292, 1980.

    Google Scholar 

  27. Chen, Y.F., M.D. Lindheimer, and S. Oparil, Increased vasopressinergic activity following DOCA administration in the rat, Brain Res Bull 16: 93–98, 1986.

    Article  PubMed  Google Scholar 

  28. Itaya, Y., H. Suzuki, S. Matsukawa, K. Kondo, and T. Saruta, Central renin-angiotensin system and the pathogenesis of DOCA-salt hypertension in rats, Am J Physiol 251: H261–H268, 1986.

    PubMed  CAS  Google Scholar 

  29. Weyhenmeyer, J.A., and J.M. Meyer, Angiotensin II in the brain and brainsten of the DOCA salt hypertensive rat, Clin Exp Hyperten A7 73–92, 1985.

    Article  CAS  Google Scholar 

  30. Gutkind, J.S. M. Kurihara, E. Castrén, and J.M. Saavedra, Atrial natriuretic peptide receptors in sympathetic ganglia: biochemical response and alterations in genetically hypertensive rats, Biochem Biophys Res Commun 149: 65–72, 1987.

    Article  PubMed  CAS  Google Scholar 

  31. Crofton, J.T., L. Share, R.E. Shade, C. Allen, and D. Tanowski, Vasopressin in the rat with spontaneous hypertension, Am J Physiol 235: H361–H366, 1978.

    PubMed  CAS  Google Scholar 

  32. Wilson, K.M., C. Sumners, S. Hathaway, and M.J. Fregly, Mineralo-corticoids modulate central angiotensin II receptors in rats, Brain Res 382: 87–96, 1986.

    Article  PubMed  CAS  Google Scholar 

  33. Israel, A., F.M.A. Correa, M. Niwa, and J.M. Saavedra, Quantitative determination of angiotensin II binding sites in rat brain and pituitary gland by autoradiography, Brain Res 322: 341–345, 1984.

    Article  PubMed  CAS  Google Scholar 

  34. Akaishi, T., H. Negoro, and S. Kobayasi, Electrophysiological evidence for multiple sites of actions of angiotensin II for stimulating paraventricular neurosecretory cells in the rat, Brain Res 220:386–390,1981.

    Article  PubMed  CAS  Google Scholar 

  35. Ferguson, A.V., and L.P. Renaud, Hypothalamic paraventricular neucleus lesions decrease pressor responses to subfornical organ stimulation, Brain Res 305: 361–364, 1984.

    Article  PubMed  CAS  Google Scholar 

  36. Killcoyne, M.M., D. L. Hoffman, and E.H. Zimmerman, Immunocytochemical localization of angiotensin II and vasopressin in rat hypothalamus: evidence for production in the same neuron, Clin Sci 59:57S–60S, 1980.

    Google Scholar 

  37. Mangiapane, M.L., T.N. Thrasher, L.C. Keil, J.B. Simpson, and W.F. Ganong, Deficits in drinking and vasopressin secretion after lesions of the nucleus medianus, Neuroendocrinology 37: 73–77, 1983.

    Article  PubMed  CAS  Google Scholar 

  38. Matsuguchi, H., and P.G. Schmid, Pressor response to vasopressin and impaired baroreflex funcion in DOCA-salt hypertension, Am J Physiol 242: H44–H49, 1982.

    PubMed  CAS  Google Scholar 

  39. Nazarail, A.J., J.S. Gutkind, and J.M. Saavedra, Regulation of angiotensin II binding sites in subfornical organ and other rat brain nuclei after water deprivation, Cell Mol Neurobiol 7: 447–455, 1987.

    Article  Google Scholar 

  40. Mann, J.F.E., A.K. Johnson, and D. Ganten, Plasma angiotensin II: dipsogenic levels and angiotensin-generating capacity of renin, Am J Physiol 238: R372–R377, 1980.

    PubMed  CAS  Google Scholar 

  41. Castrén, E., and J.M. Saavedra, Angiotensin II receptors in paraventricular nucleus, subfornical organ, and pituitary gland of hypophysectomized, adrenalectomized, and vasopressin-deficient rats, Proc Natl Acad Sci USA 86: 725–729, 1989.

    Article  PubMed  Google Scholar 

  42. Jindra, A., Jr., R. Kvetanský, T.I. Belova, and K.V. Sudakov, Effect of acute and repeated immobilization stress on plasma renin activity, catecholamines and corticosteroids in Wistar and August rats, In E. Usdin, R. Kvetanský, and I.J. Kopin (eds) Catecholamines and Stress: Recent Advances ,Elsevier/North Holland, Amsterdam, pp. 249–254, 1980.

    Google Scholar 

  43. Douglas, J.G., Corticosteroids decrease glomerular angiotensin receptors, Am J Physiol 252: F453–457, 1987.

    PubMed  CAS  Google Scholar 

  44. Spinedi, E., C.A. Johnston, A. Chisari, and A. Negro-Vilar, Role of central epinephrine on the regulation of corticotropin-releasing factor and adrenocorticotropin secretion, Endocrinology 122:1977–1983,1988.

    Article  PubMed  CAS  Google Scholar 

  45. Sokol, H.W., and E.A. Zimmerman, The hormonal status of the Brattleboro rat, In H.W. Sokol and H. Valtin (eds) The Brattleboro Rats ,The New York Academy of Sciences, New York, 394: 535–548,1982.

    Google Scholar 

  46. Hasegawa, H., A. Nasjletti, K. Rice, and G.M.C. Masson, Role of pituitary and adrenals in the regulation of plasma angiotensinogen, Am J Physiol 225: 1–6, 1973.

    PubMed  CAS  Google Scholar 

  47. King, S.J., J.W. Harding, and K.E. Moe, Elevated salt appetite and brain binding of angiotensin II in mineralocorticoid-treated rats, Brain Res 448: 140–149, 1988.

    Article  PubMed  CAS  Google Scholar 

  48. Yagil, Y., and L.R. Karkoff, The differential effect of aldosterone and dexamethasone on pressor responses in adrenalectomized rats, Hypertension 11: 174–178, 1988.

    PubMed  CAS  Google Scholar 

  49. Saavedra, J.M., A. Israel, F.M.A. Correa, and M. Kurihara, Increased atrial natriuretic peptide (6-33) binding sites in the subfornical organ of water deprived and Brattleboro rats, Proc Soc Exp Biol Med 182: 559–563, 1986.

    PubMed  CAS  Google Scholar 

  50. Saavedra, J.M., A. Israel, and M. Kurihara, Increased atrial natriuretic peptide binding sites in the rat subfornical organ after water deprivation, Endocrinology 120: 426–428, 1987.

    Article  PubMed  CAS  Google Scholar 

  51. Ogawa, K., MA. Henry, J. Tange, EA. Woodcock, and C.I. Johnston, Atrial natriuretic peptide in dehydrated Long-Evans rats and Brattleboro rats, Kidney Int 31: 760–765, 1987.

    Article  PubMed  CAS  Google Scholar 

  52. Lloyd, C.W., E. Loewy, S. Pierog, K. Bradwick, and R. Sostheim, Presence of antidiuretic material in blood of hypophysectomized rats, Proc Soc Exp Biol Med 85: 333–336, 1954.

    PubMed  CAS  Google Scholar 

  53. Samson, W.K., M.C. Aguila, J. Martinovic, J. Antunes-Rodrigues, and M. Norris, Hypothalamic action of atrial natriuretic factor to inhibit vasopressin secretion, Peptides 8: 449–454, 1987.

    Article  PubMed  CAS  Google Scholar 

  54. Sandaert, D.G., D.F. Cechetto, P. Needleman, and C.P. Saper, Inhibition of the firing of vasopressin neurons by atriopeptin, Nature 329: 151–153, 1987.

    Article  Google Scholar 

  55. Zamir, N., M. Haass, J.R. Dave, and Z. Zukowska-Grojec, Anterior pituitary gland modulates the release of atrial natriuretic peptides from cardiac atria, Proc Natl Acad Sci USA 84: 541–545, 1987.

    Article  PubMed  CAS  Google Scholar 

  56. Januszewicz, P., G. Thibault, J. Gutkowska, R. Garcia, C. Mercure, F. Jolicoeur, J. Genest, and M. Cantin, Atrial natriuretic factor and vasopressin during dehydration and rehydration in the rat, Am J Physiol 251: E497–E501, 1986.

    PubMed  CAS  Google Scholar 

  57. Saavedra, J.M., Regulation of atrial natriuretic peptide receptors in the rat brain, Cell Mol Neurobiol 7: 151–173, 1987.

    Article  PubMed  CAS  Google Scholar 

  58. Castrén, E., and J.M. Saavedra, Lack of vasopressin increases hypothalamic atrial natriuretic peptide binding sites, Am J Physiol 257 R168–R173, 1989.

    PubMed  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Section on Pharmacology, Laboratory of Clinical Science, National Institute of Mental Health, Bethesda, MD, 20892, USA

    J. M. Saavedra

Authors
  1. J. M. Saavedra
    View author publications

    You can also search for this author in PubMed Google Scholar

Editor information

Editors and Affiliations

  1. The University of Texas Southwestern Medical Center at Dallas, Dallas, Texas, USA

    John C. Porter

  2. Institute of Experimental Endocrinology, Bratislava, Czechoslovakia

    Daniela Ježová

Rights and permissions

Reprints and permissions

Copyright information

© 1990 Plenum Press, New York

About this chapter

Cite this chapter

Saavedra, J.M. (1990). Interactions Between the Circulating Hormones Angiotensin and Atrial Natriuretic Peptide and Their Receptors in Brain. In: Porter, J.C., Ježová, D. (eds) Circulating Regulatory Factors and Neuroendocrine Function. Advances in Experimental Medicine and Biology, vol 274. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-5799-5_12

Download citation

  • DOI: https://doi.org/10.1007/978-1-4684-5799-5_12

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4684-5801-5

  • Online ISBN: 978-1-4684-5799-5

  • eBook Packages: Springer Book Archive

Publish with us

Policies and ethics

Search

Navigation