Therapeutic Effects of Neuroactive Drugs on Hypothalamo-Pituitary in Man
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The treatment of endocrine disorders by neuropharmacological manipulation is a therapeutic field that has only began to be exploited in the last twenty years, and continues to evolve rapidly. In 1947, it was first suggested by Green and Harris (1) that hypothalamic substances regulated hormone secretion from the anterior pituitary. Corticotropin-releasing factor was the first of these substances to be identified in a bioassay system, while in 1982 the most recent hypothalamic peptide, growth hormone releasing hormone (GHRH), was sequenced. Paralleling the identification of the hypothalamic peptides has been progress in understanding the complex interactions of the innervation of the hypothalamus. With this knowledge, and the concomitant availability of biosynthetic hypothalamic peptides, modulation of the secretion of prolactin, growth hormone (GH) and adrenocorticotropin by manipulation of the hypothalamic-pituitary axis has resulted in major therapeutic advances. This chapter will confine itself to the drugs relevant to these hormones, but excludes analogues of the hypothalamic peptides such as octreotide and the GnRH superagonists.
KeywordsGrowth Hormone Dopamine Agonist Growth Hormone Release Hormone Sodium Valproate Exogenous Growth Hormone
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