Abstract
Kindling and long term potentiation (LTP) are among the most widely studied models of neural plasticity. In many respects they are strikingly similar. In addition to the fact that they both model CNS plasticity, the method of inducing them and the neural responses that result are very similar. For example, both are usually induced by the localized application of brief, high-frequency trains of electrical pulses through implanted electrodes, and both result in a lasting increase in the neural response to a constant stimulus (2,10). In addition, recent research has suggested that the two models may share aspects of a common underlying neural mechanism, and this has led to the suggestion that LTP might constitute the cellular mechanism of kindling (1,7,17).
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
Preview
Unable to display preview. Download preview PDF.
References
Baudry, M., 1986, Long-term potentiation and kindling: Similar biochem-ical mechanisms?, in: “Advances in Neurology”, Vol. 44, A.V. Delgado- Escueta et al., ed., Raven Press, New York.
Bliss, T.P. and Lomo, T., 1973, Long-lasting potentiation of synaptic transmission in the dentate area of the anesthetized rabbit following stimulation of the perforant path. J Physiol, 232: 331.
Buzsaki, G., Grastyan, E., Czopf, J., Kellenyi, L. and Prohaska, O., 1981, Changes in neuronal transmission in the rat hippocampus during behavior. Brain Res, 1981, 225: 235.
. Cain, D.P., 1989, Long-term potentiation and kindling: How similar are the mechanisms? Trends Neurosci, 12: 6.
. Cain, D.P., Desborough, K.A. and McKitrick, D.J., 1988, Retardation of amygdala kindling by antagonism of NMD-aspartate and muscarinic cholinergic receptors: Evidence for the summation of excitatory mechanisms in kindling. Exper Neurol, 100: 179.
. Cain, D.P., Raithby, A. and Corcoran, M.E., 1989, Urethane anesthesia blocks the development and expression of kindled seizures. Life Sci, 44: 1201.
. Collingridge, G.L. and Bliss, T.P., 1987, NMDA receptors - Their role in long-term potentiation. Trends Neurosci, 10: 288.
. de Jong, M. and Racine, R.J., 1985, The effects of repeated induction of long-term potentiation in the dentate gyrus. Brain Res, 328: 181.
. Gilbert, M., 1988, The NMDA-receptor antagonist, MK-801, suppresses limbic kindling and kindled seizures. Brain Res, 463: 90.
. Goddard, G.V., McIntyre, D.C. and Leech, C.K., 1969, A permanent change in brain function resulting from daily electrical stimulation. Exper Neurol, 25: 295.
Harris, E.W., Ganong, A.H. and Cotman, C.W., 1984, Long-term potentiation in the hippocampus involves activation of N-methyl-D-aspartate receptors. Brain Res, 323: 132.
Maru, E. and Goddard, G., 1987, Alteration in dentate neuronal activities associated with perforant path kindling. III. Enhancement of synaptic inhibition. Exper Neurol, 96: 46.
Morris, R.G.M., Anderson, E., Lynch, G.S. and Baudry, M., 1986, Selective impairment of learning and blockade of long-term potentiation by an Nmethyl-D-aspartate receptor antagonist, AP5. Nature, 319: 774.
Racine, R.J., 1972, Modification of seizure activity by electrical stimulation: II. Motor seizure. Electroencephalogr Clin Neurophysiol, 32: 281.
Racine, R.J., Burnham, W.M., Gartner, J.G. and Levitan, D., 1973, Rates of motor seizure development in rats subjected to electrical brain stimulation: Strain and interstimulation interval effects. Electroencephalogr Clin Neurophysiol, 35: 553.
Racine, R.J., Burnham, W.M., Gilbert, M.E. and Kairiss, E.W., 1986, Kindling mechanisms: I. Electrophysiological studies, in: “Kindling 3” J.A. Wada, ed., Raven Press, New York.
Slater, N.T., Stelzer, A. and Galvan, M., 1985, Kindling-like stimulus patterns induce epileptiform discharges in the guinea pig in vitro hippo-campus. Neurosci Lett, 60: 25.
Sutula, T. and Steward, 0., 1987, Facilitation of kindling by prior induction of long-term potentiation in the perforant path. Brain Res, 420: 109.
Tuff, L.P., Racine, R.J. and Adamec, R., 1983, The effects of kindling on GABA-mediated inhibition in the dentate gyrus of the rat. I. Paired-pulse depression. Brain Res, 277: 79.
Author information
Authors and Affiliations
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 1990 Plenum Press, New York
About this chapter
Cite this chapter
Cain, D.P., Boon, F., Hargreaves, E.L. (1990). Pharmacological Dissociation between the Mechanisms of Kindling and Long-Term Potentiation by APV and Urethane Anesthesia. In: Wada, J.A. (eds) Kindling 4. Advances in Behavioral Biology, vol 37. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-5796-4_25
Download citation
DOI: https://doi.org/10.1007/978-1-4684-5796-4_25
Publisher Name: Springer, Boston, MA
Print ISBN: 978-1-4684-5798-8
Online ISBN: 978-1-4684-5796-4
eBook Packages: Springer Book Archive