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Can Kindling-Induced Sleep Pathology be Corrected by Phenobarbital?

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Kindling 4

Part of the book series: Advances in Behavioral Biology ((ABBI,volume 37))

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Abstract

Kindled seizure susceptibility, as indicated by the incidence of interictal discharge (IID) and the development of kindled convulsion with an ‘all-or-none’ response to threshold stimulation, is known to persist in amygdaloid (AM) kindled cats for more than 12-months without applying stimulation.1 Many antiepileptic drugs such as Phenobarbital (PB), Phenytoin, Carbamazepine, Valproic Acid and Primidone have been shown to exert either a prophylactic effect on kindling or an anticonvulsive effect on established kindled seizure.2–8 However, the question of whether medication with these drugs can reverse the once established kindled seizure susceptibility remains unanswered.

Supported by grants from Medical Research Council of Canada to JAW

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Author information

Authors and Affiliations

  1. National Epilepsy Center, Shizuoka Higashi Hospital, Shizuoka 420, Japan

    Toshio Hiyoshi

  2. Neuroscience and Neurology, University of British Columbia, Vancouver, B.C., Canada, V6T 1W5

    Juhn A. Wada

Authors
  1. Toshio Hiyoshi
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  2. Juhn A. Wada
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Editors and Affiliations

  1. Neurosciences and Neurology, University of British Columbia, Vancouver, British Columbia, Canada

    Juhn A. Wada

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© 1990 Plenum Press, New York

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Hiyoshi, T., Wada, J.A. (1990). Can Kindling-Induced Sleep Pathology be Corrected by Phenobarbital?. In: Wada, J.A. (eds) Kindling 4. Advances in Behavioral Biology, vol 37. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-5796-4_22

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  • DOI: https://doi.org/10.1007/978-1-4684-5796-4_22

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4684-5798-8

  • Online ISBN: 978-1-4684-5796-4

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