Abstract
The kindling effect provides an excellent animal model of human epilepsy, which has been defined as a chronic brain disorder characterized by recurrence of seizures due to excessive discharge of cerebral neurons. In clinical respests, a long lasting seizure susceptibility of the brain relates to outcome of epilepsy, while recurrence of seizures, especially epileptic status, results in difficulties in social functioning of the patients with epilepsy. Using kindling model, these two different processes (seizure susceptibility and seizure induction) can be clearly identified by separating the processes of seizure development during kindling sessions and the fully kindled seizures. In addition, it seems noteworthy that the fully kindled convulsive seizure is different from acute convulsions such as pentetrazol- and penicillin-induced convulsions, due to involvement of kindling-induced seizure susceptibility of the brain in induction of seizures.
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References
R. J. Racine, Modification of seizure activity by electrical stimulation: I. Afterdiscnarge thresnold. Electroenceph. clin. Neurophysiol., 32: 269–279 (1972)
K. Sato, K. Morimoto, and S. OtsuKi, Anticonvulsant action of amino acid antagonists against kindled hippocaapal seizures. Brain des., 463: 12–20 (1e83)
J.A. Kempf, A.G. Foster, and F.H.F. Wong, Non-competitive antagonists of excitatory amino acids receptors. Trends Neurosci., 10: 294–290 (1937)
R. J. Racine, F. Newberry, and W. M. Burnham, Post-activation potentiation and the kindling phenomenon. Electroenceph. clin. Neurophysiol., 39: 261–271 (1975)
R. M. Douglas, and G.V. Goddard G.V., Long-term potentiation of the perforantpath–granule cell synapse in the rat hippocampus. Brain Res., 86: 205–215 (1975)
E. J. Goan, W. Saywood, and G.L. Collingridge, MK-801 blocks NMDA receptor-mediated synaptic transmission and long term potentiation in rat hippocampal slices. Neurosci. Lett., 80: 111–114 (1987)
K. Akiyama, and M. Sato, Neurochemistry of kindling (in Jpn). Protein, Nucleic Acid and Enzyme, 34: in press, (1989)
K. Akiyama, N. Yamada, and H. Sato, Increase in ibotenate-stimulated phosphatidylinositoihydrolysis in slices of the amygdala/pyriform cortex and hippocampus of rat by amygdala kindling. Exp. Reurol., 98: 499–508 (1987)
M. J. ladolora, F. Nicoletti, J. R. Naranjo, F. Putnam, and E. Costa, Kindling enhances the stimulation of inositol phospholipid hydrolysis elicited by ibotenic acid in rat hippocampal slices. Brain Res., 274: 174–178 (1986)
K. Akiyama, N. Yamada, and S. Otsuki, Lasting increase in excitatory amino acid receptor-mediated polyphosphoinositide hydrolysis in the amygdala/pyriform cortex of amygdala kindled rats. Brain Res. 485: 95–101 (1989)
N. Yamada, K. Akiyama, and S. Otsuki, Hippocampal kindling enhances excitatory amino acid receptor-mediated polyphosphoinositol hydrolysis in the hippocumpus and amygdala/pyriform cortex. Brain Res., 490: 126–132 (1989)
G. Guela, P.A. Jarvie, T.C. Logan, and J.T. Slevin, Long-term enhancement of K+-evoked release of L-glutamate in entorhinal kindled rats. Neurochem., 48: 999–1017 (1988)
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© 1990 Plenum Press, New York
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Sato, M., Morimoto, K., Akiyama, K., Okamoto, M. (1990). Kindling and Excitatory Amino Acids. In: Wada, J.A. (eds) Kindling 4. Advances in Behavioral Biology, vol 37. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-5796-4_18
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DOI: https://doi.org/10.1007/978-1-4684-5796-4_18
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