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Kindling 4 pp 209–225Cite as

Does Electrical and Excitatory Amino Acid Kindling Share a Common Neurobiological Mechanism?

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Part of the book series: Advances in Behavioral Biology ((ABBI,volume 37))

Abstract

There is convincing evidence that excitatory amino acids, particularly glutamate (GLU) and aspartate (ASP), are involved in basic mechanism of epilepsy (for reviews see refs. 1,2,26). Thus, enhanced release, and reduced tissue levels, of excitatory amino acids have been reported in various animal models of epilepsy (9,13,20,24,34,41,44). Reduced levels of both GLU and ASP have also been demonstrated in tissue excised from human epileptic foci (42,43). In addition, excitatory amino acid antagonists have been shown to block epileptic seizures and epileptiform activity in both rodent and primate models of epilepsy (4,5,6,26,34,39,40).

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Author information

Authors and Affiliations

  1. Department of Neuropsychiatry, Fukushima Medical College, Japan

    Norio Mori

  2. Division of Neurosciences and Neurology, University of B.C., Canada

    Juhn A. Wada

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  1. Norio Mori
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  2. Juhn A. Wada
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Editors and Affiliations

  1. Neurosciences and Neurology, University of British Columbia, Vancouver, British Columbia, Canada

    Juhn A. Wada

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© 1990 Plenum Press, New York

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Mori, N., Wada, J.A. (1990). Does Electrical and Excitatory Amino Acid Kindling Share a Common Neurobiological Mechanism?. In: Wada, J.A. (eds) Kindling 4. Advances in Behavioral Biology, vol 37. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-5796-4_16

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  • DOI: https://doi.org/10.1007/978-1-4684-5796-4_16

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4684-5798-8

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