Abstract
This chapter will consider recent pharmacologic, electrophysiologic, and biochemical studies examining the role of a subtype of excitatory amino receptor, the NMDA receptor, in the development of kindling and expression of kindled seizures.
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Nowak, L., Bregestovski, P., Ascher, P., Herbert, A., and Prochiantz, A., 1984, Magnesium gates glutamate-activated channels in mouse central neurons, Nature. 307: 462.
Mayer, M.L., Westbrook, G.L., and Gutherie, P.B., 1984, Voltage-dependent block by magnesium of NMDA responses in spinal cord neurons. Nature. 309: 261.
Herron, C.E., Lester, R.A., Coan, E.J., and Collingridge, J.L., 1985, Intracellular demonstration of an N-methyl-D-aspartate receptor mediated component of synaptic transmission in the rat hippocampus, Neurosci.Lett. 60: 19.
Hynes, M.A. and Dingledine, R., 1984, Attenuation of epileptiform burst firing in the rat hippocampal slice by antagonists of N-methyl-D-aspartate receptors, Soc.Neurosci. Abst. 10: 229.
Croucher, M.J., Collins, J.F., and Meldrum, B.S., 1982, Anticonvulsant action of excitatory amino acid antagonists, Science 216: 899.
Czuczwar, S.J. and Meldrum, B.S., 1982, Protection against chemically induced seizures by 2-amino-7-phosphonoheptanoic acid, Eur. J. Pharmacol. 83: 335.
Cline, H.T., Debski, E.A., and Constantine-Paton, M., 1987, N-methyl-D-aspartate receptor antagonist desegregates eye-specific stripes, Proc.Natl.Acad.Sci. U.S.A. 84: 4342.
Harris, E.W., Ganong, A.H., and Cotman, C.W., 1984, Long-term potentiation in the hippocampus involves activation of N-methyl-D-aspartate receptors. Brain Res. 323: 132.
Morris, R.G.M., Anderson, E., Lynch. G.S., and Baudry, M., 1986, Selective impairment of learning and blockage of long-term potentiation by an N-methyl-D-aspartate receptor antagonist, AP5, Nature 319: 774.
McNamara, J.O., Russell, R.D., Rigsbee, L., and Bonhaus, D.W., 1988, Anticonvulsant and antiepileptogenic actions of MK-801 in the kindling and electroshock models, Neuropharmacology 27: 563.
Callaghan, D.A. and Schwark, W.S., 1980, Pharmacological modification of amygdaloidkindled seizures, Neuropharmacolom, 19: 1131.
Bowyer, J.F., and Winters, E.D., 1981, The effects of various anesthetics on amygdaloid kindled seizures, Neuropharmacologv 20: 199.
Bowyer, J.F., 1982, Phencyclidine inhibition of the rate of kindling development. Exp. Neurol. 75: 173.
Bowyer, J.F., Albertson, T.E., Winters, W.D. and Baselt, R.C., 1983, Ketamine-induced changes in kindled amygdaloid seizures, Neuropharmacologv 22: 887.
Holmes, K.H. and Goddard, G.B., 1986, A role for the N-methyl-D-aspartate receptor in kindling, Proc. Univ.Otago Med. Sch. 64: 37.
Cain, D.P., Desborough, K.A., McKitrick, D.J., 1988, Retardation of amygdaloid kindling by antagonism of NMD-aspartate and muscarinic cholinergic receptors: evidence for the summation of excitatory mechanisms in kindling, Exp. Neurol. 100: 203.
Vezzanni, A., Wu, H.Q., Moneta, E., and Samanin, R., 1988, Role of the N-methyl-Daspartate-type receptors in the development and maintenance of hippocampal kindling in rats, Neurosci.Lett. 87: 63.
Sato, K., Morimoto, K., and Okamoto, M., 1988, Anticonvulsant action of a noncompetitive antagonist of NMDA receptors (MK-801) in the kindling model of epilepsy, Brain Res. 463: 12.
Gilbert, M.E., 1988, The NMDA-receptor antagonist, MK-801, suppresses limbic kindling and kindled seizures, Brain Res. 463: 90.
McNamara, J.O., Shin, C., Butler, L., and Rigsbee, L.C., 1989, Intravenous phenytoin is an effective anticonvulsant in the kindling model, Annals of Neurol., in press.
Albright, P.S., and Burnham, W.M., 1980, Development of a new pharmacological seizure model: effects of anticonvulsants on cortical-and amygdala-kindled seizures in the rat, Epilepsia 21: 681.
Albertson, T.E., Peterson, S.L., Stark, L.G., 1980, Anticonvulsant drugs and their antagonism of kindled amygdaloid seizures in rats, Neuropharmacology 19: 643.
Mody, I. and Heinemann, U., 1987, NMDA receptors of dentate gyrus granule cells participate in synaptic transmission following kindling, Nature 326: 701.
Baudry, M., Evans, M., Lynch, G., 1986, Excitatory amino acids inhibit stimulation of phosphoinositide metabolism by aminergic agonists in hippocampus, Nature 319: 329.
Morrisett, R.A., Chow, C.C., Sakaguchi, T., Shin, C., and McNamara, J.O., 1989, Inhibition of muscarinic-coupled phosphoinositide hydrolysis by N-methyl-D-aspartate is dependent upon depolarization via channel activation. J. Neurochem., in press.
Mayer, M.L., and Westbrook, G.L., 1987, The physiology of excitatory amino acids in the vertebrate central nervous system, Prof.Neurobiol. 28: 197.
Morrisett, R.A., Chow, C., Nadler, J.V., and McNamara, J.O., 1989, Biochemical evidence for enhanced sensitivity to N-methyl-D-aspartate in the hippocampal formation of kindled rats, Brain Res., in press.
Okazaki, M.M., McNamara, J.O., and Nadler, J.V., 1989, N-methyl-D-aspartate receptor autoradiography in rat brain after angular bundle kindling, Brain Res. 482: 359.
Lambert, J.D.C., and Jones, R.S.G., 1989, Activation of N-methyl-D-aspartate receptors contributes to the EPSP at perforant path synapses in the rat dentate gyrus in vitro, Neurosci. Lett. 97: 323.
Sakmann, B., Methfessel, C., Mishina, M., Takahashi, T., Takai, T., Kurasaki, M., Fukuda, K., Numa, S., 1985, Role of acetylcholine receptor subunits in fazing of the channel, Nature 318: 538.
Mishina, M., Takai, T., Imoto, K., Takahashi, T., Numa, S., Methsessel, C. and Sakmann, B., 1986, Molecular distinction between fetal and adult form of muscle acetylcholine receptor, Nature 321: 406.
Levitan, E.S., Schofield, P.R., Burt, D.R., Rhee, L.M., Wisden, W., Kohler, M., Fujita, N., Rodriguez, H.F., Stephenson, A., Darlison, M.D., Barnard, E.A., and Seebug, P.H. 1988, Structural and functional basis of GABAA receptor heretogeneity, Nature 335: 76.
Geula, C., Harvie, P.A., Logan, T.C. and Slevin, J.R., 1988, Long-term enhancement of IC-evoked release of L-glutamate in entorhinal kindled rats, Brain Res., 442: 368.
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© 1990 Plenum Press, New York
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McNamara, J.O., Bonhaus, D.W., Nadler, J.V., Yeh, GC. (1990). N-Methyl-D-Aspartate (NMDA) Receptors and the Kindling Model. In: Wada, J.A. (eds) Kindling 4. Advances in Behavioral Biology, vol 37. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-5796-4_15
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DOI: https://doi.org/10.1007/978-1-4684-5796-4_15
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