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The Role of Protein Kinase C Substrate B-50 (GAP-43) in Neurotransmitter Release and Long-Term Potentiation

  • Chapter
Excitatory Amino Acids and Neuronal Plasticity

Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 268))

Abstract

Long-term potentiation (LTP) is a form of synaptic plasticity, which may be one of the events underlying learning and memory. LTP is triggered by brief, high-frequency stimulation of afferents, resulting in a long-lasting increase in the effectiveness of synaptic transmission (Bliss and Lomo, 1973; Bliss and Lynch, 1988; Brown et al., 1988; Matthies, 1989). Traditionally, LTP has been divided into two phases, the initiation phase and the maintenance phase. At present, three phases can be distinguished: (i) an initiation phase, including several seconds after tetanic stimulation when the events that trigger LTP begin; (ii) a transient phase, lasting about 30 min, during which there is a slow decay of potentiation, which can be evoked by local transmitter application without stimulating the presynaptic terminal; and (iii) a maintenance phase, which can last for hours (Kauer et al., 1988; Malinow et al., 1988a).

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Authors and Affiliations

  1. Division of Molecular Neurobiology, Rudolf Magnus Institute, Laboratory for Physiological Chemistry, Institute of Molecular Biology and Medical Biotechnology, Padualaan 8, 3584 CH, Utrecht, NL

    P. N. E. De Graan, L. H. Schrama, F. M. J. Heemskerk, L. V. Dekker & W. H. Gispen

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  1. P. N. E. De Graan
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  1. Institut National de la Sante et de la Recherche Medicale, Paris, France

    Yehezkel Ben-Ari

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De Graan, P.N.E., Schrama, L.H., Heemskerk, F.M.J., Dekker, L.V., Gispen, W.H. (1990). The Role of Protein Kinase C Substrate B-50 (GAP-43) in Neurotransmitter Release and Long-Term Potentiation. In: Ben-Ari, Y. (eds) Excitatory Amino Acids and Neuronal Plasticity. Advances in Experimental Medicine and Biology, vol 268. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-5769-8_38

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  • DOI: https://doi.org/10.1007/978-1-4684-5769-8_38

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4684-5771-1

  • Online ISBN: 978-1-4684-5769-8

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