Abstract
Recent work has demonstrated an involvement of the NMDA receptor, a type of glutamate-sensitive receptor, in organizing the developing visual systems of frogs, fish and kittens (Cline et al, 1987; Kleinschmidt et al, 1987; Fox and Fraser, 1987; Tsumoto et al, 1987; Scherer and Udin, 1988; Schmidt, 1988; Cline and Constantine-Paton, 1989; Fox et al, 1989). It is thought that the NMDA receptor activation may be an initial cellular event in the experience-dependent phases of visual development, which include the formation of both topographic maps and ocular dominance columns. In this chapter, we will review our electrophysiological and anatomical data which demonstrate that NMDA receptor activation is crucial for the development of the retinotectal projection of the frog Rana pipiens and we will end with a discussion of the influence of the NMDA receptor in neuronal growth.
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Cline, H.T., Debski, E.A., Constantine-Paton, M. (1990). The Role of the NMDA Receptor in the Development of the Frog Visual System. In: Ben-Ari, Y. (eds) Excitatory Amino Acids and Neuronal Plasticity. Advances in Experimental Medicine and Biology, vol 268. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-5769-8_23
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DOI: https://doi.org/10.1007/978-1-4684-5769-8_23
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