Abstract
During the last decade numerous reports have described a previously unappreciated but nonetheless common process of central nervous system development: the transient overproduction of axonal projections early in postnatal life. Several groups have shown that during maturation terminal axonal branches are pruned and long axonal collaterals degenerate (for review see Cowan et al., 1984; Easter et al., 1985; Stanfield, 1984). With axon elimination, associated synapses would also be lost. Consistent with this are results of ultrastructural studies that have shown that the density of synapses in cortex early in postnatal life is higher than in the adult (Huttenlocher et al., 1982; Huttenlocher, 1984; Rakic et al., 1986). Elimination of functional synapses has been shown to occur at both the neuromuscular junction and in autonomic ganglion during maturation (Purves and Lichturan, 1980). One example of functional synapse regression in the central nervous system is the transient multiple innervation of Purkinje cells by climbing fibers (Crepel, 1982).
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
Preview
Unable to display preview. Download preview PDF.
References
Ben-Ari, Y., Krnjevic, K, and Reinhardt, W., 1979, Hippocampal seizures and failure of inhibition, Can. J. Physiol. Pharmacol, 57: 1462–1466.
Ben-Ari, Y., Cherubini, E., and Krnjevic, K., 1988, Changes in voltage dependence of NMDA currents during development, Neurosci. Letts, 94: 88–92.
Brady, R.J. and Swann, J.W., 1984, Postsynaptic actions of baclofen associated with its antagonism of bicuculline-induced epileptogenesis in hippocampus, Cell. Mol. Neurobiol, 4: 403–408.
Brady, R.J. and Swann, J.W., 1986, Ketamine selectively suppresses synchronized afterdischarges in immature hippocampus, Neurosci. Letts, 69: 143–149.
Brady, R.J. and Swann, J.W., 1988, Suppression of ictal-like activity by kynurenic acid does not correlate with its efficacy as an NMDA receptor antagonist, Epilepsy Res, 2: 232–238.
Brady, R.J. and Swann, J.W., 1988, The effects of extracellular calcium on the epileptiform activity and NMDA responses are different in mature and immature hippocampal slices, Neurosci. Abstr, 14: 239.
Cline, H.T., Debski, E.A., and Constantine-Paton, M., 1987, N-methyl-D-aspartate receptor antagonist desegregates eye-specific stripes, Proc. Natl. Acad. Sci. USA, 84: 4342–4345.
Cowan, W.M., Fawcett, J.W., O’Leary, D.D.M., and Stanfield, B.B., 1984, Regressive events in neurogenesis, Science, 225: 1258–1265.
Crepel, F., 1982, Regression of functional synapses in the immature mammalian cerebellum, TINS, 5: 266–269.
Cotman, C.W., Bridges, R.J., Taube, J.S., Clark, A.S., Geddes, J.W., and Monaghan, D.T., 1989, The role of the NMDA receptor in central nervous system plasticity and pathology, J. NIH Res, 1: 65–74.
Easter, S.S.Jr., Purves, D., Rakic, P., and Spitzer, N.C., 1985, The changing view of neural specificity, Science, 230: 507–511.
Ganong, A.H., Lanthorn, T.H. and Cotman, C.W., 1983, Kynurenic add inhibits synaptic and acidic amino add-induced responses in the rat hippocampus and spinal cord, Brain Res, 272: 170–174.
Grenningloh, G., Rienitz, A., Schmitt, B., Methfessel, C., Zensen, M., Beyreuther, K., Gundelfinger, E.D., Betz, H., 1987, The strychnine-binding subunit of the glycine receptor shows homology with nicotinic acetylcholine receptors, Nature, 328: 215–220.
Haberly, L.B. and Bower, J.M., 1989, Olfactory cortex: model circuit for study of associative memory?, TINS, 12: 258–264.
Huttenlocher, P.R., de Courten, C., Garey, L.J., and van der Loos, H., 1982, Synaptogenesis in human visual cortex–evidence for synapse elimmination during normal development, Neurosci. Letts, 33: 247–252.
Huttenlocher, P.R., 1984, Synapse elimination and plasticity in developing human cerebral cortex, Amer. J. Mental Defic, 5: 488–496.
Kleinschmidt, A., Bear, M.F., and Singer, W., 1987, Blockade of NMDA receptors disrupts experience-dependent plasticity of kitten striate cortex, Science, 238: 355–358.
Lynch, G., “Synapses, Circuits, and the Beginnings of Memory,” M.S. Gazzaniga, ed., The MIT Press, Cambridge (1986).
McCarren, M., and Alger, B.E., 1985, Use-dependent depression of ipsps in rat hippocampal pyramidal cells in vitro, J. Neurophysiol, 53: 557–571.
Miles, R. and Wong, R.K.S., 1983, Single neurones can initiate synchronized population discharge in the hippocampus, Nature, 306: 371–373.
Miles, R. and Wong, R.K.S., 1986, Excitatory synaptic interactions between CA3 neurons in the guinea-pig hippocampus, J. Physiol, 373: 397–418.
Miles, R. and Wong, R.K.S., 1987(a), Latent synaptic pathways revealed after tetanic stimulation in the hippocampus, Nature, 329: 724–726.
Miles, R. and Wong, R.K.S., 1987(b), Inhibitory control of local excitatory circuits in the guinea-pig hippocampus, J. Physiol, 388: 611–629.
Mishina, M., Takai, T., Imoto, K., Noda, M., Takahashi, T., Numa, S., Methfessel, C., and Sakmann, B., 1986, Molecular distinction between fetal and adult forms of muscle acetylcholine receptor, Nature, 321: 406–411.
Purpura, D.P., Prelevic, S., and Santini, M., 1968, Postsynaptic potential and spike variation in the feline hippocampus during postnatal ontogenesis, Exp. Neurol, 22: 408–422.
Purves, D. and Lichtman, J.W., 1980, Elimination of synapses in the developing nervous system, Science, 210: 153–157.
Rakic, P., Bourgeois, J.-P., Eckenhoff, M.F., Zecevic, N., Goldman-Rakic, P.S., 1986, Concurrent overproduction of synapses in diverse regions of the primate cerebral cortex, Science, 232: 232–235.
Schneiderman, J.H., 1986, Low concentrations of penicillin reveal rhythmic, synchronous synaptic potentials in hippocampal slice, Brain Res, 398: 231–241.
Schofield, P.R., Darlison, M.G., Fujita, N., Burt, D.R., Stephenson, F.A., Rodriguez, H., Rhee, L.M., Ramachandran, J., Reale, A.V., Glencourse, T.A., Seeburg, P.H., and Barnard, E.A., 1987, Sequence and functional expression of the GABAA receptor shows a ligand-gated receptor super-family, Nature, 328: 221–227.
Schwartzkroin, P.A., 1982, Development of rabbit hippocampus: physiology, Dev. Brain Res, 2: 469–486.
Schwartzkroin, P.A. and Haglund, M.M., 1986, Spontaneous rhythmic synchronous activity in epileptic human and normal monkey temporal lobe, Epilepsia, 27: 523–533.
Stanfield, B.B., 1984, Postnatal reorganization of cortical projections: the role of collateral elimination, TINS, 7: 37–41.
Smith, K.L., Turner, J. and Swann, J.W., 1988, Paired intracellular recordings reveal mono-and polysynatpic excitatory interactions in immature hippocampus, Neurosci. Abstr, 14: 883.
Swann, J.W. and Brady R.J., 1984, Penicillin-induced epileptogenesis in immature rat CA3 hippocampal pyramidal cells, Des,. Brain Res, 12: 243–254.
Swann, J.W., Brady, R.J., and Martin, D.L., 1989, Postnatal development of GAGA-mediated synaptic inhibition in rat hippocampus, Neuroscience, 28: 551–561.
Traub, R.D., Miles, R., and Wong, R.K.S., 1989, Model of the origin of rhythmic population oscillations in the hippocampal slice, Science, 243: 1319–1325.
Author information
Authors and Affiliations
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 1990 Springer Science+Business Media New York
About this chapter
Cite this chapter
Swann, J.W., Smith, K.L., Brady, R.J. (1990). Neural Networks and Synaptic Transmission in Immature Hippocampus. In: Ben-Ari, Y. (eds) Excitatory Amino Acids and Neuronal Plasticity. Advances in Experimental Medicine and Biology, vol 268. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-5769-8_19
Download citation
DOI: https://doi.org/10.1007/978-1-4684-5769-8_19
Publisher Name: Springer, Boston, MA
Print ISBN: 978-1-4684-5771-1
Online ISBN: 978-1-4684-5769-8
eBook Packages: Springer Book Archive