Abstract
Approximately 60% of all soft tissue and osteogenic sarcomas and 50% of all melanomas arise in the extremities. Treatment of these tumors has traditionally been limited to local surgical procedures, often resulting in a non-functioning limb or amputation, particularly in the case of sarcoma and in a local recurrence rate Primarily related to the biological tumor aggressiveness. A higi incidence of micrometastatic nodules has been found in most high-grade sarcomas and in high-risk melanomas in the form of “skip” or “in transit” metastases. This suggests that these tumors cannot be managed as locally confined neoplasms, being a regional disease “ab initio” and requiring loco-regional treatment.
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© 1990 Plenum Press, New York
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Di Filippo, F. et al. (1990). The Role of Hyperthermic Perfusion in the Treatment of Tumors of the Extremities. In: Bicher, H.I., McLaren, J.R., Pigliucci, G.M. (eds) Consensus on Hyperthermia for the 1990s. Advances in Experimental Medicine and Biology, vol 267. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-5766-7_22
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DOI: https://doi.org/10.1007/978-1-4684-5766-7_22
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