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Receptor-Based Design of Dihydrofolate Reductase Inhibitors

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Protein Design and the Development of New Therapeutics and Vaccines

Part of the book series: New Horizons in Therapeutics ((NHTH))

Abstract

The enzyme dihydrofolate reductase (DHFR) has become a well-established target for drug action since it was identified about 30 years ago. Clinically useful drugs whose activity stems from DHFR inhibition include the antibacterial agent trimethoprim (TMP, 1) (see Finland et al., 1982), and methotrexate (MTX, 2) (see Roth and Cheng, 1982), a compound used in the treatment of certain forms of cancer.

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Authors and Affiliations

  1. Wellcome Research Laboratories, Research Triangle Park, North Carolina, 27709, USA

    Lee F. Kuyper

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  1. Lee F. Kuyper
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  1. Smithkline Beecham Pharmaceuticals, Philadelphia, Pennsylvania, USA

    Jerry B. Hook  & George Poste  & 

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© 1990 Plenum Press, New York

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Kuyper, L.F. (1990). Receptor-Based Design of Dihydrofolate Reductase Inhibitors. In: Hook, J.B., Poste, G., Schatz, J. (eds) Protein Design and the Development of New Therapeutics and Vaccines. New Horizons in Therapeutics. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-5739-1_15

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  • DOI: https://doi.org/10.1007/978-1-4684-5739-1_15

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  • Online ISBN: 978-1-4684-5739-1

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