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Role of Membrane Receptors in Stimulus-Secretion Coupling

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Transduction in Biological Systems

Abstract

In the last two decades there has been an exponential increase in our fundamental knowledge of hormone receptors. The literature accumulated is so vast that it is impossible to cover in any depth, in a short review, all the aspects of hormone-receptor interaction. In this chapter we will consider only two aspects. First, the modulation of the membrane-bound enzyme system adenylate cyclase, and, second, the perturbation of the phosphoinositide cycle caused by neurotransmitters involved in the neural control of catecholamine and insulin secretion. To this end, a mechanism for the generation of intracellular signals resulting from the activation of adrenergic and cholinergic receptors will be also considered, and illustrative examples of receptor-controlled electrical activity and ATP secretion will be presented.

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Author information

Authors and Affiliations

  1. Laboratory of Cell Biology and Genetics, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, Maryland, 20892, USA

    Eduardo Rojas, Rosa M. Santos & Illani Atwater

Authors
  1. Eduardo Rojas
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  2. Rosa M. Santos
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  3. Illani Atwater
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Editors and Affiliations

  1. Centro de Estudios Científicos de Santiago, Universidad de Chile, Santiago, Chile

    Cecilia Hidalgo  & Enrique Jaimovich  & 

  2. Universidad de Chile, Santiago, Chile

    Juan Bacigalupo

  3. University of California at Los Angeles, Los Angeles, California, USA

    Julio Vergara

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© 1990 Plenum Press, New York

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Rojas, E., Santos, R.M., Atwater, I. (1990). Role of Membrane Receptors in Stimulus-Secretion Coupling. In: Hidalgo, C., Bacigalupo, J., Jaimovich, E., Vergara, J. (eds) Transduction in Biological Systems. Series of the Centro de Estudios Científicos de Santiago. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-5736-0_8

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  • DOI: https://doi.org/10.1007/978-1-4684-5736-0_8

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4684-5738-4

  • Online ISBN: 978-1-4684-5736-0

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