Skip to main content
SpringerLink
Log in
Book cover

Transduction in Biological Systems pp 449–462Cite as

Metabolism of Phosphoinositides in Skeletal Muscle Membranes

  • Chapter

Abstract

The activation of a number of cell surface receptors results in the formation of inositol phosphates and diacylglycerol (DAG) through the cleavage of membrane phosphoinositides by phospholipase-C.

This is a preview of subscription content, log in via an institution.

Chapter
USD   29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD   39.99
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD   54.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Learn about institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. Majerus, P. W., Connolly, T. M., Deckmyn, H., Ross, T. S., Bross, T. E., Ishii, H., Bansal, V. S., and Wilson, D. B., 1986, The metabolism of phosphoinositide-derived messenger molecules, Science 234: 1519–1526.

    Article  PubMed  CAS  Google Scholar 

  2. Sekar, M. C., and Hokin, L. E., 1986, The role of phosphoinositides in signal transduction, J. Membrane Biol. 89: 193–210.

    Article  CAS  Google Scholar 

  3. Berridge, M. J., 1987, Inositol trisphosphate and diacylglycerol: Two interacting second messengers, Ann. Rev. Biochem. 56: 159–193.

    Article  PubMed  CAS  Google Scholar 

  4. Berridge, M. J., 1988, Inositol lipids and calcium signalling, Proc. Royal Soc. London 234: 359–378.

    Article  CAS  Google Scholar 

  5. Majerus, P. W., Connolly, T. M., Bansal, V. S., Inhora, R. C., Ross, T. S., and Lips, D. L., 1988, Inositol phosphates: Synthesis and degradation, J. Biol. Chem. 263: 3051–3054.

    PubMed  CAS  Google Scholar 

  6. Guillemette, G., Baila, T., Baukal, A. J., and Cart, K. J., 1988, Characterization of inositol 1,4,5-trisphosphate receptors and calcium mobilization in a hepatic plasma membrane fraction, J. Biol. Chem. 263: 4541–4548.

    PubMed  CAS  Google Scholar 

  7. Nishizuka, Y., 1984, The role of protein kinase-C in cell surface signal transduction and tumor promotion, Nature 308: 693–697.

    Article  PubMed  CAS  Google Scholar 

  8. Nishizuka, Y., 1986, Studies and perspectives of protein kinase-C., Science 233: 305–312.

    Article  PubMed  CAS  Google Scholar 

  9. Whitman, M., Downes, C. P., Keeler, M., Keller, T., and Cantley, L., 1988, Type I phos-phatidylinositol kinase makes a novel inositol phospholipid, phosphatidylinositol-3-phosphate, Nature 332: 644–646.

    Article  PubMed  CAS  Google Scholar 

  10. Cockcroft, S., 1986, The dependence on Ca2+ of the guanine-nucleotide-activated polyphosphoinositide phosphodiesterase in neutrophil plasma membranes, Biochem. J. 240: 503–507.

    PubMed  CAS  Google Scholar 

  11. Lo, W. W. Y., and Hughes, J., 1987, Receptor-phosphoinositidase-C coupling: Multiple G-pro-teins? FEBS Lett. 224: 1–3.

    Article  PubMed  CAS  Google Scholar 

  12. Downes, C.P., Mussat, M. C., and Michell, R. H., 1982, The inositol trisphosphate Phosphomonoesterase of the human erythrocyte membrane, Biochem. J. 203: 169–177.

    PubMed  CAS  Google Scholar 

  13. Storey, D. J., Shears, S. B., Kirk, C. J., and Michell, R. H., 1984, Stepwise enzymatic de-phosphorylation of inositol 1,4,5-trisphosphate to inositol in liver, Nature 312: 374–376.

    Article  PubMed  CAS  Google Scholar 

  14. Batty, I. R., Nahorski, S. R., and Irvine, R. F., 1985, Rapid formation of inositol 1,3,4,5-tetrakisphosphate following muscarinic receptor stimulation of rat cerebral cortical slices, Biochem. J. 232: 211–215.

    PubMed  CAS  Google Scholar 

  15. Burguess, G. M., McKinney, J. S., Irvine, R. F., and Putney, Jr., J. W., 1985, Inositol 1,4,5-trisphosphate and inositol 1,3,4-trishosphate formation in Ca2+-mobilizing hormone-activated cells, Biochem. J. 232: 237–243.

    Google Scholar 

  16. Irvine, R. F., Anggard, E. E., Letcher, A. J., and Downes, C. P., 1985, Metabolism of inositol 1,4,5-trisphosphate and inositol 1,3,4-trisphosphate in rat parotid glands, Biochem. J. 229: 505–511.

    PubMed  CAS  Google Scholar 

  17. Hansen, C. A., Mak, S., and Williamson, J. R., 1986, Formation and metabolism of inositol 1,3,4,5-tetrakisphosphate in liver, J. Biol. Chem. 261: 8100–8103.

    PubMed  Google Scholar 

  18. Biden, T. J., and Wollheim, C. B., 1986, Ca2+ regulates the inositol tris/tetrakisphosphate pathway in intact and broken preparations of insulin-secreting RIN mSF cells, J. Biol. Chem. 261: 11931–11934.

    PubMed  CAS  Google Scholar 

  19. Daniel, J. J., Dangelmaier, C. A., and Smith, J. B., 1988, Calcium modulates the generation of inositol 1,3,4-trisphosphate in human platelets by the activation of inositol 1,4,5-trisphosphate 3-kinase, Biochem. J. 253: 789–794.

    PubMed  CAS  Google Scholar 

  20. Irvine, R. F., and Moor, R. M., 1986, Microinjection of inositol 1,3,4,5-tetrakisphosphate activates sea urchin eggs by a mechanism dependent on external Ca2+, Biochem. J. 240: 917–920.

    PubMed  CAS  Google Scholar 

  21. Morris, A. P., Gallacher, D. V., Irvine, R. F., and Petersen, O. H., 1987, Synergism of inositol trisphosphate and tetrakisphosphate in activating Ca2+-dependent K+ channels, Nature 330: 653–655.

    Article  PubMed  CAS  Google Scholar 

  22. Hill, T. D., Dean, N. M., and Boynton, A. L., 1988, Inositol 1,3,4,5-tetrakisphosphate induces Ca2+ sequestration in rat liver cells, Science 242: 1176–1178.

    Article  PubMed  CAS  Google Scholar 

  23. Doughney, C., McPherson, M. A., and Dormer, R. L., 1988, Metabolism of inositol 1,3,4,5-tetrakisphosphate by human erythrocyte membranes: A new mechanism for the formation of inositol 1,4,5-trisphosphate, Biochem. J. 251: 927–929.

    PubMed  CAS  Google Scholar 

  24. Baila, T., Guillemette, G., Bambol, A. J., and Cart, K. J., 1987, Metabolism of inositol 1,3,4-trisphosphate to a new tetrakisphosphate isomer in angiotensin-stimulated adrenal glomerulosa cells, J. Biol. Chem. 262: 9952–9955.

    Google Scholar 

  25. Shears, S. B., Parry, J. B., Tang, E. K. Y., Irvine, R. F., Michell, R. H., and Kirk, C. J., 1987, Metabolism of D-myo-inositol 1,3,4,5-tetrakisphosphate by rat liver, including the synthesis of a novel isomer of myo-inositol tetrakisphosphate, Biochem. J. 246: 139–147.

    PubMed  CAS  Google Scholar 

  26. Stephens, L. R., Hawkins, P. T., Barber, C. J., and Downes, C. P., 1988, Synthesis of myo-inositol 1,3,4,5,6-pentakisphosphate from inositol phosphates generated by receptor activation, Biochem. J. 253: 721–733.

    PubMed  CAS  Google Scholar 

  27. Heslop, J. P., Irvine, R. F., Tashjian, A. H., Jr., and Berridge, M. J., 1985, Inositol tetrakis- and pentakisphosphates in GH4 cells, J. Exp. Biol. 119: 395–401.

    PubMed  CAS  Google Scholar 

  28. Vallejo, M., Jackson, T., Lightman, S., and Hanley, M. R., 1987, Occurrence and extracellular actions of inositol pentakis- and hexakisphosphate in mammalian brain, Nature 330: 656–658.

    Article  PubMed  CAS  Google Scholar 

  29. Vergara, J., Tsien, R. Y., and Delay, M., 1985, Inositol 1,4,5-trisphosphate: Possible chemical link in excitation-contraction coupling in muscle, Proc. Natl. Acad. Sci. USA 82: 6352–6356.

    Article  PubMed  CAS  Google Scholar 

  30. Volpe, P., Salviati, G., Di Virgilio, F., and Pozzan, T., 1985, Inositol trisphosphate induces Ca2+ release from the sarcoplasmic reticulum of skeletal muscle, Nature 316: 347–349.

    Article  PubMed  CAS  Google Scholar 

  31. Hidalgo, C., Carrasco, M. A., Magendzo, K., and Jaimovich, E., 1986, Phosphorylation of phosphatidylinositol by transverse tubule vesicles and its possible role in excitation-contraction coupling, FEBS Lett. 202: 69–73.

    Article  PubMed  CAS  Google Scholar 

  32. Carrasco, M. A., Magendzo, K., Jaimovich, E., and Hidalgo, C., 1988, Calcium modulation of phosphoinositide kinases in transverse tubule vesicles from frog skeletal muscle, Arch. Biochem. Biophys. 262: 306–366.

    Article  Google Scholar 

  33. Varsanyi, M., Messer, M., Brandt, N. R., and Heilmeyer, L. M. G., 1986, Phosphatidylinositol 4,5-bisphosphate formation in rabbit skeletal and heart muscle membranes, Biochem. Biophys. Res. Commun. 138: 1395–1404.

    Article  PubMed  CAS  Google Scholar 

  34. Varsanyi, M., Messer, M., and Brandt, N. R., 1989, Intracellular localization of inositol-phos-pholipid-metabolizing enzymes in rabbit fast twitch skeletal muscle: Can D-myo-inositol 1,4,5-trisphosphate play a role in excitation-contraction coupling? Eur. J. Biochem. 179: 473–479.

    Article  PubMed  CAS  Google Scholar 

  35. Jay, S. D., and Campbell, K. P., 1988, Characterization of phosphatidylinositol 4,5-bisphosphate production in skeletal muscle triads, Biophys. J. 53: 467a.

    Google Scholar 

  36. Hidalgo, C., Parra, C., Riquelme, G., and Jaimovich, E., 1986, Transverse tubules from frog skeletal muscle: Purification and properties of vesicles sealed with the inside-out orientation, Biochem. Biophys. Acta 855: 79–88.

    Article  PubMed  CAS  Google Scholar 

  37. Hidalgo, C., Gonzalez, M. E., and Lagos, R., 1983, Characterization of the Ca2+ — or Mg2+ -ATPase of transverse tubule membranes isolated from rabbit skeletal muscle, J. Biol. Chem. 258: 13937–13945.

    PubMed  CAS  Google Scholar 

  38. Collins, C. A., and Wells, W. W., 1983, Identification of phosphatidylinositol kinase in rat liver lysosomal membranes, J. Biol. Chem. 258: 2130–2134.

    PubMed  CAS  Google Scholar 

  39. Guisto, N. M., and Ilincheta de Boschero, M. G., 1986, Synthesis of polyphosphoinositids in vertebrate photoreceptor membranes, Biochim. Biophys. Acta 877: 440–446.

    Google Scholar 

  40. Yamakawa, A., and Takenawa, T., 1988, Purification and characterization of membrane-bound phosphatidylinositol kinase from rat brain, J. Biol. Chem. 263: 17555–17560.

    PubMed  CAS  Google Scholar 

  41. Tooke, N. E., Hales, C. N., and Hatton, J. C., 1984, Ca2+ -sensitive phosphatidylinositol 4-phosphate metabolism in a rat β-cell tumor, Biochem. J. 219: 471–480.

    PubMed  CAS  Google Scholar 

  42. Rios, E., and Brum, G., 1987, Involvement of dihydropyridine receptors in excitation-contraction coupling in skeletal muscle, Nature 325: 717–720.

    Article  PubMed  CAS  Google Scholar 

  43. Di Virgilio, F., Salviati, G., Pozzan, T., and Volpe, P., 1986, Is a guanine nucleotide-binding protein involved in excitation-contraction coupling in skeletal muscle? EMBO J. 5: 259–262.

    PubMed  Google Scholar 

  44. Salviati, G., Betto, R., Tegazzin, V., and Delia Puppa, A., 1988, Subcellular localization of G-protein and phospholipase-C activity in rabbit skeletal muscle, Biophys. J. 53: 332a.

    Google Scholar 

  45. Donaldson, S. K., Goldking, N. D., Walseth, T. F., and Huettemann, D. A., 1987, Inositol trisphosphate stimulates Ca2+ release from peeled skeletal muscle fibers, Biochem. Biophys. Acta 927: 92–99.

    Article  PubMed  CAS  Google Scholar 

  46. Suarez-Isla, B., Irribarra, V., Bull, R., Oberhauser, A., Larralde, L., Hidalgo, C., and Jaimovich, E., 1988, Inositol 1,4,5-trisphosphate activates a calcium channel in isolated sarcoplasmic reticulum membranes, Biophys. J. 54: 737–741.

    Article  PubMed  CAS  Google Scholar 

  47. Lagos, N., and Vergara, J., 1989, Phosphoinositide kinase and phospholipase-C activities in T-tubule membrane vesicles of frog skeletal muscle, Biophys. J. 55: 236a.

    Google Scholar 

  48. Schacht, J., 1976, Inhibition by neomycin of polyphosphoinositide turnover in subcellular fractions of guinea-pig cerebral cortex in vitro, J. Neurochem. 27: 1119–1124.

    Article  PubMed  CAS  Google Scholar 

  49. Reid, D. G., and Gajjar, K., 1987, A proton and carbon-13 nuclear magnetic resonance study of neomycin B and its interactions with phosphatidylinositol 4,5-bisphosphate, J. Biol. Chem. 262: 7967–7972.

    PubMed  CAS  Google Scholar 

  50. Kasianowicz, J., Gabev, E., and McLaughlin, S., 1988, The binding of neomycin to phosphatidylinositol 4,5-bisphosphate (PIP2), Biophys. J. 53: 517a.

    Google Scholar 

  51. Lysnes, O-B., Verhoeven, A. J. M., and Holmsen, H., 1987, Neomycin inhibits agonist-stimulated polyphosphoinositide metabolism and responses in human platelets, Biochem. Biophys. Res. Commun. 144: 454–462.

    Article  Google Scholar 

  52. Hidalgo, C., and Jaimovich, E., 1989, Inositol trisphosphate and excitation-contraction coupling in skeletal muscle, J. Bioenerg. Biomemb. 21: 267–281.

    Article  CAS  Google Scholar 

  53. Milani, D., Volpe, P., and Pozzan, T., 1988, D-myo-inositol 1,4,5-trisphosphate phosphatase in skeletal muscle, Biochem. J. 254: 525–529.

    PubMed  CAS  Google Scholar 

  54. Janiak, M. J., Small, D. M., and Shipley, G. G., 1979, Temperature and compositional dependence of the structure of hydrated dimyristoyl lecithin, J. Biol. Chem. 254: 6068–6078.

    PubMed  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Departamento de Fisiología y Biofísica, Facultad de Medicina, Universidad de Chile, Santiago, Chile

    Cecilia Hidalgo, Ximena Sánchez & M. Angélica Carrasco

  2. Centro de Estudios Científicos de Santiago, Santiago, Chile

    Cecilia Hidalgo

Authors
  1. Cecilia Hidalgo
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Ximena Sánchez
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. M. Angélica Carrasco
    View author publications

    You can also search for this author in PubMed Google Scholar

Editor information

Editors and Affiliations

  1. Centro de Estudios Científicos de Santiago, Universidad de Chile, Santiago, Chile

    Cecilia Hidalgo  & Enrique Jaimovich  & 

  2. Universidad de Chile, Santiago, Chile

    Juan Bacigalupo

  3. University of California at Los Angeles, Los Angeles, California, USA

    Julio Vergara

Rights and permissions

Reprints and permissions

Copyright information

© 1990 Plenum Press, New York

About this chapter

Cite this chapter

Hidalgo, C., Sánchez, X., Carrasco, M.A. (1990). Metabolism of Phosphoinositides in Skeletal Muscle Membranes. In: Hidalgo, C., Bacigalupo, J., Jaimovich, E., Vergara, J. (eds) Transduction in Biological Systems. Series of the Centro de Estudios Científicos de Santiago. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-5736-0_31

Download citation

  • DOI: https://doi.org/10.1007/978-1-4684-5736-0_31

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4684-5738-4

  • Online ISBN: 978-1-4684-5736-0

  • eBook Packages: Springer Book Archive

Publish with us

Policies and ethics

Search

Navigation