Abstract
A key issue when postulating a role for inositol 1,4,5-trisphosphate (IP3) as a messenger in excitation-contraction coupling in skeletal muscle is whether the effect of exogenous IP3 on skeletal muscle fibers is compatible with the effect postulated for a physiological intracellular transmitter. It is important to establish then whether IP3 acts at concentrations that are low enough, whether its action is fast enough, and whether it is specific and compatible with the known physiological properties of the process.
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References
Vergara, J., Tsien, R. Y., and Delay, M., 1985, Inositol 1,4,5-trisphosphate: A possible chemical link in excitation-contraction coupling in muscle, Proc. Natl. Acad. Sci. USA 82: 6352–6356.
Vergara, J., Asotra, K., and Delay, M., 1987, in: Cell Calcium and the Control of Membrane Transport (L. J. Mandel and D. G. Eaton, Eds.), pp. 133–151, The Rockefeller University Press, New York.
Volpe, P., Salviati, G., Di Virgilio, F., and Pozzan, T., 1985, Inositol 1,4,5-trisphosphate induces calcium release from sarcoplasmic reticulum skeletal muscle, Nature 316: 347–349.
Volpe, P., Di Virgilio, F., Pozzan, T., and Salviati, G., 1986, Role of inositol 1,4,5-trisphosphate in excitation-contraction coupling in skeletal muscle, FEBS Lett. 197: 1–4.
Nosek, T. M., Williams, M. F., Zeigler, J. T., and Godt, R. E., 1986, Inositol trisphosphate enhances calcium release in skinned cardiac and skeletal muscle, Am. J. Physiol. 250: C807–C810.
Donaldson, S. K., Goldberg, N. D., Walseth, T. F., and Huettemann, D. A., 1987, Inositol trisphosphate stimulates calcium release from peeled skeletal muscle fibers, Biochem. Biophys. Acta 927: 92–99.
Rojas, E., Nassar-Gentina, V., Luxoro, M., Pollard, M. E., and Carrasco, M. A., 1987, Inositol 1,4,5-trisphosphate-induced Ca +2 release from sarcoplasmic reticulum and contraction in crustacean muscles, Can. J. Physiol. Pharmacol. 65: 672–680.
Sherer, N. M., and Ferguson, J. E., 1985, Inositol 1,4,5-trisphosphate is not effective in releasing calcium from skeletal sarcoplasmic reticulum microsomes, Biochem. Biophys. Res. Commun. 128: 1064–1070.
Palade, P., 1987, Drug-induced Ca +2 release from isolated sarcoplasmic reticulum. III. Block of Ca +2-induced Ca+2 release by organic polyamines, J. Biol. Chem. 262: 6149–6154.
Mikos, G. J., and Snow, T. R., 1987, Failure of inositol 1,4,5-trisphosphate to elicit or potentiate Ca +2 release from isolated skeletal muscle sarcoplasmic reticulum, Biochim. Biophys. Acta 927: 256–260.
Lea, T. J., Griffiths, D. J., Treagar, R. T., and Ashley, C. C., 1986, An examination of the ability of inositol 1,4,5-trisphosphate to induce calcium release and tension development in skinned skeletal muscle fibers of frog and crustacea, FEBS Lett. 203: 153–161.
Blinks, J. R., Cai, Y. D., and Lee, N. K. M., 1987, Inositol 1,4,5-trisphosphate causes calcium release in frog skeletal muscle only when transverse tubules have been interrupted, J. Physiol. (London) 394: 39P.
Walker, J. W., Somlyo, A. V., Goldman, Y. E., Somlyo, A. P., and Trentham, D. R., 1987, Kinetics of smooth and skeletal muscle activation by laser pulse photolysis of caged inositol 1,4,5-trisphosphate, Nature 327: 249–252.
Rojas, C., Rojas, E., Kukuljan, M., and Jaimovich, E., 1988, Inositol 1,4,5-trisphosphate induces calcium release from skinned frog skeletal muscle, Biophys. J. 53: 467a.
Rojas, C., and Jaimovich, E., 1990, Calcium release modulated by inositol trisphosphate in skinned fibers from frog skeletal muscle, Eur. J. Physiol, (in press).
Donaldson, S. K., 1988, Transverse tubule voltage control of inositol trisphosphate-induced Ca2+ release in peeled skinned muscle fibers, Biophys. J. 53: 468a.
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© 1990 Plenum Press, New York
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Jaimovich, E., Rojas, C., Rojas, E. (1990). Calcium Release in Skinned Muscle Fibers: Effect of Inositol 1,4,5-Trisphosphate. In: Hidalgo, C., Bacigalupo, J., Jaimovich, E., Vergara, J. (eds) Transduction in Biological Systems. Series of the Centro de Estudios Científicos de Santiago. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-5736-0_30
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DOI: https://doi.org/10.1007/978-1-4684-5736-0_30
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