Abstract
Electron-transfer reactions as well as the generation and reactivity of free radicals in biological systems are controlled by thermodynamic-, kinetic-, and environmental factors1. The redox chemistry of hydro- and semi-quinones is in large extent determined by the physico-chemical properties of the molecule, such as the reduction potential and the influ- ence on it of the substitution pattern, by environmental factors, such as pH, solvent cage, solvation energy, and medium polarity, and by kinetic factors, which can allow a reaction -otherwise thermodynamically unlikely- to proceed by exerting a modification on its equilibrium.
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Cadenas, E., Ernster, L. (1990). Effect of Superoxide Dismutase on the Autoxidation of Hydroquinones Formed During DT-Diaphorase Catalysis and Glutathione Nucleophilic Addition. In: Emerit, I., Packer, L., Auclair, C. (eds) Antioxidants in Therapy and Preventive Medicine. Advances in Experimental Medicine and Biology, vol 264. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-5730-8_6
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