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Antioxidant Effects in Radioprotection

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Antioxidants in Therapy and Preventive Medicine

Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 264))

Abstract

Reactive Oxygen Intermediates and Oxygen Metabolism. Reactive Oxygen intermediates such as O -2 , H2O2 and OH might not be generated only during the initial radiolytic phase of radia tion injury, but also in a later metabolic phase, involving oxygen. The consumption of oxygen and simultaneous oxidative damage in vivo have been considered as well documented hypotheses. Therefore oxygen supply and utilization seems to share a pivotal role in radiation effects, as well as in other domains where oxidative injury may happen1,2,3. As Koppenol wrote: Thus… “Oxygen not only makes the formation of an oxidizing radical possible, it also exacerbates damage through chain reactions”…

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Authors and Affiliations

  1. Centre de Recherches du Service de Santé des Armées, 24, Avenue des Maquis du Grésivaudan, BP87, 38700, LA Tronche/Grenoble, France

    P. Bienvenu, F. Herodin, M. Fatome & J. F. Kergonou

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  1. P. Bienvenu
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  2. F. Herodin
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  3. M. Fatome
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  4. J. F. Kergonou
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Editors and Affiliations

  1. Centre National de la Recherche Scientifique, University of Paris, Paris, France

    Ingrid Emerit

  2. Dept. of Physiology Anatomy, University of California, Berkeley, Berkeley, California, 94720, USA

    Lester Packer

  3. Institut Gustave-Roussy, 94800, Villejuif, France

    Christian Auclair

  4. Groupe de Recherche Radicaux Libres, Institut Biomédical des Cordeliers, 15, Rue de l’Ecole de Médecine, 75006, Paris, France

    Ingrid Emerit

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Bienvenu, P., Herodin, F., Fatome, M., Kergonou, J.F. (1990). Antioxidant Effects in Radioprotection. In: Emerit, I., Packer, L., Auclair, C. (eds) Antioxidants in Therapy and Preventive Medicine. Advances in Experimental Medicine and Biology, vol 264. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-5730-8_47

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