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Oxygen Toxicity: Role of Hydrogen Peroxide and Iron

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Antioxidants in Therapy and Preventive Medicine

Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 264))

Abstract

An important factor in tissue damage by toxic oxygen species is the ability to increase the level of hydrogen peroxide. This inter mediate of oxygen reduction is not only a precursor of species with a higher reactivity, such as the hydroxyl radical, but it also controls the process of inflammatation by its effect on the synthesis of vasoactive and chemotactic compounds. However, tissue injury by hydrogen peroxide often, if not always, depends on the availability of catalytic iron.

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Authors and Affiliations

  1. Department of Medicine, University of Utrecht, 3511 GV, Utrecht, The Netherlands

    B. S. van Asbeck

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  1. B. S. van Asbeck
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Editors and Affiliations

  1. Centre National de la Recherche Scientifique, University of Paris, Paris, France

    Ingrid Emerit

  2. Dept. of Physiology Anatomy, University of California, Berkeley, Berkeley, California, 94720, USA

    Lester Packer

  3. Institut Gustave-Roussy, 94800, Villejuif, France

    Christian Auclair

  4. Groupe de Recherche Radicaux Libres, Institut Biomédical des Cordeliers, 15, Rue de l’Ecole de Médecine, 75006, Paris, France

    Ingrid Emerit

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van Asbeck, B.S. (1990). Oxygen Toxicity: Role of Hydrogen Peroxide and Iron. In: Emerit, I., Packer, L., Auclair, C. (eds) Antioxidants in Therapy and Preventive Medicine. Advances in Experimental Medicine and Biology, vol 264. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-5730-8_38

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  • DOI: https://doi.org/10.1007/978-1-4684-5730-8_38

  • Publisher Name: Springer, Boston, MA

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