Abstract
The incidence of postischemic paraparesis or paraplegia following thoracoabdominal aneurysm repair ranges between 4 and 30% (Crawford et al., 1986). Inspite numerous surgical techniques prolonged hypoxia of the lower parts of the spinal cord cannot always be avoided. Thus, application of pharmacological agents during ischemia and/or the reperfusion period for the reduction of spinal cord injury is appealing and has been the goal of numerous investigations (Faden et al., 1984; Lim et al., 1986; Oldfield et al., 1982) The following study was designed to evaluate the protective effect of the antioxidant Superoxide dismutase (SOD) in order to minimize the so called “reperfusion injury”. In the animal study spinal cord function was measured by somatosensory evoked potentials (SEP) in order to determine the effectiveness of therapy. Additionally, the neurological outcome and the hiostological findings were compared to a non treated group.
This is a preview of subscription content, log in via an institution to check access.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
Preview
Unable to display preview. Download preview PDF.
References
Crawford, E.S., Crawford, J.L., Safi, H.J., Coselli, J.S., Hess, K.R., Brooks, B., Norton, H.J. and Glaeser, D.H., 1986, Thoracoabdominal aortic aneurysms: Preoperative and intraoperative factors determining immediate and long-term results of operations in 605 patients. J Vasc Surg, 3: 389
Faden, F.J., Jacobs, T.P., and Smith, M.T., 1984, Evaluation of the calcium channel antagonist nimopidine in experimental spinal cord ischemia. J Neurosurg, 60: 796
Hess, M.L. and Manson, N.H., 1984, Molecular oxygen: Friend and foe. The role of the oxygen free radical system in the calcium paradox, the oxygen paradox and ischemia/reperfusion injury. J Mol Cell Cardiol, 16: 969
Kaschner, A.G. Sandmann, W., and Larkamp, H., 1984, Percutaneous flexible bipolar epidural neuroelectrode for spinal cord stimulation. J Neurosurg, 60: 1317
Laschinger, J.C., Cunningham, J.N., Cooper, M.M., Baumann, F:G., and Spencer, F.C., 1987, Monitoring of somatosensory evoked potentials during procedures on the thoracoabdominal aorta. J Thoracc Cardiovasc Surg, 94: 260
Lim, K.H., Connoly, M., Rose, D., Siegmann, F., Jacobowitz, I., Acinapura, A., and Cunningham, J.N., 1986, Prevention of reperfusion of the ischemic spinal cord: Use of recombinant Superoxide dismutase. Ann Thorac Surg, 42: 282
Oldfield, E.H., Plunkett, R.J., Nylander, W.A., and Meacham, W.F., 1982, Barbiturate protection in acute experimental spinal cord ischemia. J Neurosurg, 56: 511
Southorn, P., 1988, Free radicals in Medicine. Mayo Clinic Proceed, 63: 390
Yatsu, F.M., 1987, Clinical aspects of reversible cerebral ischemia, in: Cerebral ischemia and hemorheology, Hartmann, Springer Verlag, Berlin, Heidelberg
Author information
Authors and Affiliations
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 1990 Plenum Press, New York
About this chapter
Cite this chapter
Grabitz, K., Freye, E., Prior, R., Kolvenbach, R., Sandmann, W. (1990). The Role of Superoxide Dismutase (SOD) in Preventing Postischemic Spinal Cord Injury. In: Emerit, I., Packer, L., Auclair, C. (eds) Antioxidants in Therapy and Preventive Medicine. Advances in Experimental Medicine and Biology, vol 264. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-5730-8_3
Download citation
DOI: https://doi.org/10.1007/978-1-4684-5730-8_3
Publisher Name: Springer, Boston, MA
Print ISBN: 978-1-4684-5732-2
Online ISBN: 978-1-4684-5730-8
eBook Packages: Springer Book Archive