Skip to main content
SpringerLink
Log in
Book cover

Antioxidants in Therapy and Preventive Medicine pp 179–182Cite as

Selenium and Glutathione Peroxidase Activity in Diploid Human Fibroblasts: Their Effects Against H2O2 or UVB Induced Toxicity

  • Chapter

  • 322 Accesses

Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 264))

Abstract

One of the proposed mechanisms of aging is generation of free radicals that have been shown to react with lipids, proteins, and DNA1.2. Trace elements by the fact of metalloenzymes (Zinc Copper Superoxide Dismutase (ZnCuSOD), Man ganese Superoxide Dismutase (MnSOD), Selenium Glutathione Peroxidase (SeGPX)) prevent such potentially toxic reactions.

This is a preview of subscription content, log in via an institution.

Chapter
USD   29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD   84.99
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD   109.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Learn about institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. S.K. Jain, Evidence for membrane lipid peroxidation during the in vivo aging of human erythroeytes, Biochim.bipphys. 6c.ta..-937 : 205–210 ( 1988 ) .

    Article  CAS  Google Scholar 

  2. T.F. Slater, Free radical mechanisms in tissue injury. Bipchem. J., 222:1–15 (1984).

    CAS  Google Scholar 

  3. K. Takahashi, P.E. Newburger, and H.J. Cohen, Glutathione peroxidase protein: Absence in selenium deficiency states and correlation with enzymatic activity. J. Clin. Invest. 77:1402–1404 (1986)

    Article  PubMed  CAS  Google Scholar 

  4. G.F. Combs and S.B. Combs, in : “The role of Selenium in nutrition,” Combs & Combs, Ed., Academic Press Inc. London (1986) pp 205–264.

    Google Scholar 

  5. W.A.Gunzler, H.Kremers, and L. Flohe. An improved coupled test procedure for glutathione peroxidase in blood. Z. Klin. Chem. Klin. Biochem. 12:444– 448 (1974).

    PubMed  CAS  Google Scholar 

  6. S.B. Dousset, M. Trouilh, and M.J. Foglietti, Plasma malonaldehyde levels during myocardial infarction. Clin. Chim. Acta. 129:319–322(1983).

    Article  PubMed  CAS  Google Scholar 

  7. Ch. Shopsis, G.J. Mackay, Semi automated assay for cell culture. Anal. Bipchem. 140:104–107 (1984).

    Article  CAS  Google Scholar 

  8. Ao Pung , liei Zhao, and Yu Shu-yu, In vitro differential effects of sodium selenite on the growth of human hepatoma cells and human embryonic liver cells. Bio. Trace Elem. Res. 14:1–17 (1987).

    Article  CAS  Google Scholar 

  9. J.F. Mead, Free radical mechanisms of lipid damage and conseguences for cellular membranes. in: “Free Radicals in Biology,” W.A. Pryor, ed., Academic Press.N.Y. (1976) 1: pp 51–66.

    Google Scholar 

  10. D. Herman, Free radicals in aging, Mol. Cell. Bipchem. 84:155–161 (1988).

    Article  Google Scholar 

  11. J. Chaudière, D. Gerard, M. Clement, J.M. Bourre. Induction of Selenium glutathione peroxidase by stimulation of metabolic hydrogen peroxide production in vivo. Bipchem. Bioenergetics 18:247–256 (1987)

    Article  Google Scholar 

  12. E. Hoffman, A.C. Mello Filho, and R. Meneghmi, Correlation between cytotoxic effect of hydrogen peroxide and the yield of DNA strand breaks in cells of different species, Biochim. bipphys. Acta. 781:234–238 (1984).

    Google Scholar 

  13. E.B. Thorling, K. Overvad, and P. Bjerring, Oral selenium inhibits skin reactions to UV light in hairless mice. Acta. Path. Micrpbiol. Immunol. Scand. Sect. A., 91:81–83 (1983).

    CAS  Google Scholar 

  14. D. Medina, H.W. Lane, and C.M. Tracey, Selenium and mouse mammary tumorigenesis : an investigation of possible mechanisms. Cancer Res. suppl.43: 2460–2464 (1983).

    CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Laboratoire de Biochimie C, C.H.R.U.G., BP 217X, 38043, Grenoble Cédex, France

    M. J. Richard, P. Frappat, J. Arnaud & A. Favier

Authors
  1. M. J. Richard
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. P. Frappat
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. J. Arnaud
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. A. Favier
    View author publications

    You can also search for this author in PubMed Google Scholar

Editor information

Editors and Affiliations

  1. Centre National de la Recherche Scientifique, University of Paris, Paris, France

    Ingrid Emerit

  2. Dept. of Physiology Anatomy, University of California, Berkeley, Berkeley, California, 94720, USA

    Lester Packer

  3. Institut Gustave-Roussy, 94800, Villejuif, France

    Christian Auclair

  4. Groupe de Recherche Radicaux Libres, Institut Biomédical des Cordeliers, 15, Rue de l’Ecole de Médecine, 75006, Paris, France

    Ingrid Emerit

Rights and permissions

Reprints and permissions

Copyright information

© 1990 Plenum Press, New York

About this chapter

Cite this chapter

Richard, M.J., Frappat, P., Arnaud, J., Favier, A. (1990). Selenium and Glutathione Peroxidase Activity in Diploid Human Fibroblasts: Their Effects Against H2O2 or UVB Induced Toxicity. In: Emerit, I., Packer, L., Auclair, C. (eds) Antioxidants in Therapy and Preventive Medicine. Advances in Experimental Medicine and Biology, vol 264. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-5730-8_28

Download citation

  • DOI: https://doi.org/10.1007/978-1-4684-5730-8_28

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4684-5732-2

  • Online ISBN: 978-1-4684-5730-8

  • eBook Packages: Springer Book Archive

Publish with us

Policies and ethics

Search

Navigation