Abstract
One of the proposed mechanisms of aging is generation of free radicals that have been shown to react with lipids, proteins, and DNA1.2. Trace elements by the fact of metalloenzymes (Zinc Copper Superoxide Dismutase (ZnCuSOD), Man ganese Superoxide Dismutase (MnSOD), Selenium Glutathione Peroxidase (SeGPX)) prevent such potentially toxic reactions.
This is a preview of subscription content, log in via an institution.
Buying options
Tax calculation will be finalised at checkout
Purchases are for personal use only
Learn about institutional subscriptionsPreview
Unable to display preview. Download preview PDF.
References
S.K. Jain, Evidence for membrane lipid peroxidation during the in vivo aging of human erythroeytes, Biochim.bipphys. 6c.ta..-937 : 205–210 ( 1988 ) .
T.F. Slater, Free radical mechanisms in tissue injury. Bipchem. J., 222:1–15 (1984).
K. Takahashi, P.E. Newburger, and H.J. Cohen, Glutathione peroxidase protein: Absence in selenium deficiency states and correlation with enzymatic activity. J. Clin. Invest. 77:1402–1404 (1986)
G.F. Combs and S.B. Combs, in : “The role of Selenium in nutrition,” Combs & Combs, Ed., Academic Press Inc. London (1986) pp 205–264.
W.A.Gunzler, H.Kremers, and L. Flohe. An improved coupled test procedure for glutathione peroxidase in blood. Z. Klin. Chem. Klin. Biochem. 12:444– 448 (1974).
S.B. Dousset, M. Trouilh, and M.J. Foglietti, Plasma malonaldehyde levels during myocardial infarction. Clin. Chim. Acta. 129:319–322(1983).
Ch. Shopsis, G.J. Mackay, Semi automated assay for cell culture. Anal. Bipchem. 140:104–107 (1984).
Ao Pung , liei Zhao, and Yu Shu-yu, In vitro differential effects of sodium selenite on the growth of human hepatoma cells and human embryonic liver cells. Bio. Trace Elem. Res. 14:1–17 (1987).
J.F. Mead, Free radical mechanisms of lipid damage and conseguences for cellular membranes. in: “Free Radicals in Biology,” W.A. Pryor, ed., Academic Press.N.Y. (1976) 1: pp 51–66.
D. Herman, Free radicals in aging, Mol. Cell. Bipchem. 84:155–161 (1988).
J. Chaudière, D. Gerard, M. Clement, J.M. Bourre. Induction of Selenium glutathione peroxidase by stimulation of metabolic hydrogen peroxide production in vivo. Bipchem. Bioenergetics 18:247–256 (1987)
E. Hoffman, A.C. Mello Filho, and R. Meneghmi, Correlation between cytotoxic effect of hydrogen peroxide and the yield of DNA strand breaks in cells of different species, Biochim. bipphys. Acta. 781:234–238 (1984).
E.B. Thorling, K. Overvad, and P. Bjerring, Oral selenium inhibits skin reactions to UV light in hairless mice. Acta. Path. Micrpbiol. Immunol. Scand. Sect. A., 91:81–83 (1983).
D. Medina, H.W. Lane, and C.M. Tracey, Selenium and mouse mammary tumorigenesis : an investigation of possible mechanisms. Cancer Res. suppl.43: 2460–2464 (1983).
Author information
Authors and Affiliations
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 1990 Plenum Press, New York
About this chapter
Cite this chapter
Richard, M.J., Frappat, P., Arnaud, J., Favier, A. (1990). Selenium and Glutathione Peroxidase Activity in Diploid Human Fibroblasts: Their Effects Against H2O2 or UVB Induced Toxicity. In: Emerit, I., Packer, L., Auclair, C. (eds) Antioxidants in Therapy and Preventive Medicine. Advances in Experimental Medicine and Biology, vol 264. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-5730-8_28
Download citation
DOI: https://doi.org/10.1007/978-1-4684-5730-8_28
Publisher Name: Springer, Boston, MA
Print ISBN: 978-1-4684-5732-2
Online ISBN: 978-1-4684-5730-8
eBook Packages: Springer Book Archive