Abstract
Several years ago, it has been shown1,2 that there was a relationship between vitamin E (Vit. E) deficiency and the neurological disorders observ ed in patients with chronic cholestasis and lipid malabsorption. We report here our clinical experience of eight years of Vit. E treatment (10 mg/kg of DL-α-tocoρherol acetate, IM, every two weeks) in these patients.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
Preview
Unable to display preview. Download preview PDF.
References
M. A. Guggenheim, S. P. Ringel, A. Silverman, B. E. Grebert, Progressive neuromuscular disease in children with chronic cholestasis and vitamin E deficiency : diagnosis and treatment with alpha-tocopherol, J. Pediatr. 100:51 (1982).
F. Alvarez, P. Landrieu, P. Laget, F. Lemonnier, M. Odièvre and D. Alagille, Nervous and ocular disorders in children with cholesta sis and vitamin A and E deficiencies, Hepatology 3:410 (1983).
F. Lemonnier, D. Cresteil, M. Fénéant, M. Couturier, 0. Bernard and D. Alagille, Plasma lipid peroxides in cholestatic children, Acta Paediatr. Scand. 76:928 (1987).
F. Babin, F. Lemonnier, A. Coguelin, D. Alagille, A. Lemonnier, Plasma fatty acid composition and lipid peroxide levels in children with paucity of interlobular bile ducts, Ann. Nutr. Metab. 32:220 (1988).
K. Yagi, A simple fluorometric assay for lipoperoxide in blood plasma, Biochem. Med. 15:212 (1976).
G. L. Catignani, J. G. Bieri, Simultaneous determination of retinol and and a-tocopherol in serum or plasma by liquid chromatograpy, Clin. Chem. 29:708 (1983).
R. J. Sokol, J. E. Heubi, B. Mc Graw, W.F. Balistreri, Correction of vitamin E deficiency in children with chronic cholestasis. II Effect on gastrointestinal and hepatic function, Hepatology 6:1263 (1986).
Author information
Authors and Affiliations
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 1990 Plenum Press, New York
About this chapter
Cite this chapter
Lemonnier, F., Alvarez, F., Babin, F., Couturier, M., Alagille, D. (1990). Effects of Vitamin E Treatment in Cholestatic Children. In: Emerit, I., Packer, L., Auclair, C. (eds) Antioxidants in Therapy and Preventive Medicine. Advances in Experimental Medicine and Biology, vol 264. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-5730-8_21
Download citation
DOI: https://doi.org/10.1007/978-1-4684-5730-8_21
Publisher Name: Springer, Boston, MA
Print ISBN: 978-1-4684-5732-2
Online ISBN: 978-1-4684-5730-8
eBook Packages: Springer Book Archive