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Regulation of Lipid Peroxidation by Glutathione and Lipoic Acid: Involvement of Liver Microsomal Vitamin E Free Radical Reductase

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Antioxidants in Therapy and Preventive Medicine

Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 264))

Abstract

Reduced glutathione (GSH) is known to play a pivotal role in the cellular oxidant defence system and is indispensable for preventing lipid peroxidation by free radicals and oxygen. In this respect several protective cytosolic and membrane bound enzymes have been described which utilize GSH as substrate or as cofactor. The respective contribution of each of these enzymes, like GSH S-transferases, selenium dependent GSH peroxidase and the selenium containing phospholipid hydroperoxide GSH peroxidase, to the oxidant defence has not been fully clarified yet1.

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Literature

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Author information

Authors and Affiliations

  1. Department of Pharmacochemistry, Faculty of Chemistry, Vrije Universiteit, De Boelelaan 1083, 1081 HV, Amsterdam, The Netherlands

    Aalt Bast & Guido R. M. M. Haenen

Authors
  1. Aalt Bast
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  2. Guido R. M. M. Haenen
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Editor information

Editors and Affiliations

  1. Centre National de la Recherche Scientifique, University of Paris, Paris, France

    Ingrid Emerit

  2. Dept. of Physiology Anatomy, University of California, Berkeley, Berkeley, California, 94720, USA

    Lester Packer

  3. Institut Gustave-Roussy, 94800, Villejuif, France

    Christian Auclair

  4. Groupe de Recherche Radicaux Libres, Institut Biomédical des Cordeliers, 15, Rue de l’Ecole de Médecine, 75006, Paris, France

    Ingrid Emerit

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© 1990 Plenum Press, New York

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Bast, A., Haenen, G.R.M.M. (1990). Regulation of Lipid Peroxidation by Glutathione and Lipoic Acid: Involvement of Liver Microsomal Vitamin E Free Radical Reductase. In: Emerit, I., Packer, L., Auclair, C. (eds) Antioxidants in Therapy and Preventive Medicine. Advances in Experimental Medicine and Biology, vol 264. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-5730-8_15

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  • DOI: https://doi.org/10.1007/978-1-4684-5730-8_15

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4684-5732-2

  • Online ISBN: 978-1-4684-5730-8

  • eBook Packages: Springer Book Archive

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