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How Safe is the Blood Supply in the United States?

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Infection Control

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Abstract

It has long been known that transfusion of blood or its derivatives may also result in the inadvertent transmission of infectious agents, particularly those associated with a silent carrier state. For many years, hepatitis and syphilis were the only diseases which were recognized as transmissible by this route, but there appeared to be relatively little anxiety among the general public. The recognition of AIDS among recipients of clotting factor concentrates and single donor transfusions was, in contrast, widely publicised and led to considerable and continuing concern. Indeed, the association between blood transfusion and AIDS became so firm that a significant proportion of the population mistakenly believed that AIDS could be contracted as a result of giving blood. The need to reduce transfusion associated AIDS led to a new and more intensive focus on the whole issue of the safety of the blood supply. In fact, in the three years following the introduction of HIV antibody screening, three additional tests were implemented by blood collection agencies as measures to reduce the transmission of other viruses. In addition, there have been demonstrable improvements in the methods used to screen the donor population and there is real hope that inactivation of viral or microbial contaminants in cellular blood products will be achieved. It will be shown that the chance of being infected by blood transfusion has never been lower than it is now. Finally, physicians have recognized the need to review the risks and benefits of every transfusion and to seek safe alternatives wherever possible.

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References

  1. Aach, R.D., W. Szmuness, J.W. Mosley, F.B. Hollinger, R.A. Kahn, C.E. Stevens, V.M. Edwards, and J. Werch. 1981. Serum alanine aminotransferase of donors in relation to the risk of non-A, non-B hepatitis in recipients. The Transfusion-Transmitted Viruses Study. N Eng J Med 304:989–994.

    Article  CAS  Google Scholar 

  2. Ablashi, D.V., S.Z. Salahuddin, S.F. Josephs, F. Imam, P. Lusso, R.C. Gallo, C. Hung, J. Lemp, and P.D. Markham. 1987. HBLV (or HHV-6) in human cell lines. Nature 329:207–207.

    Article  PubMed  CAS  Google Scholar 

  3. Allain, J.-P., Y. Laurian, D.A. Paul, D. Senn, and Members of the AIDS-Haemophilia French Study Group. 1986. Serological markers in early stages of human immunodeficiency virus infection in haemophiliacs. Lancet 2:1233–1236.

    Article  PubMed  CAS  Google Scholar 

  4. Allen, J.G. 1972. The epidemiology of posttransfusion hepatitis. Basic blood and plasma tabulations. p.1-335. Commonwealth Fund, Stanford.

    Google Scholar 

  5. Alter, H.J., R.H. Purcell, P.V. Holland, D.W. Ailing, and D.E. Koziol. 1981. Donor transaminase and recipient hepatitis. Impact on blood transfusion services. JAMA 246:630–634.

    Article  PubMed  CAS  Google Scholar 

  6. Alter, M.J., A. Mares, S.C. Hadler, and J.E. Maynard. 1987. The effect of underreporting on the apparent incidence and epidemiology of acute viral hepatitis. Amer J of Epid 125:133–139.

    CAS  Google Scholar 

  7. Anderson, M.J. 1987. Human parvovirus infections. J of Vir Meth 17:175–181.

    Article  CAS  Google Scholar 

  8. Aubuchon, J.A., and R.Y. Dodd. 1988. Analysis of the relative safety of autologous blood units available for transfusion to homologous recipients. Transfusion 28:403–405.

    Article  PubMed  CAS  Google Scholar 

  9. Azimi, P.H., R.R. Roberto, J. Guralnick, T. Livermore, S. Hoag, S. Hagens, and N. Lugo. 1986. Transfusion-acquired hepatitis A in a premature infant with secondary nosocomial spread in an intensive care nursery. Amer J Dis Children 140:23–27.

    CAS  Google Scholar 

  10. Backer, U., F. Weinauer, G. Gathof, and J. Eberle. 1987. HIV antigen screening in blood donors [letter]. Lancet 2:1213–1214.

    Article  PubMed  CAS  Google Scholar 

  11. Baker, J.L., G.D. Kelen, K.T. Sivertson, and T.C. Quinn. 1987. Unsuspected human immunodeficiency virus in critically ill emergency patients. JAMA 257:2609–2611.

    Article  PubMed  CAS  Google Scholar 

  12. Barre-Sinoussi, F., J.-C. Chermann, F. Rey, M.T. Nugeyre, S. Chamaret, J. Gruest, C. Dauguet, C. Axler-Blin, F. Brun-Vezinet, C. Rouzioux, W. Rozenbaum, and L. Montagnier. 1983. Isolation of a T-lymphotropic retrovirus from a patient at risk for acquired immune deficiency syndrome (AIDS). Science 220:868–871.

    Article  PubMed  CAS  Google Scholar 

  13. Berman, M., A.J. Alter, K.G. Ishak, R.H. Purcell, and A.E. Jones. 1979. The chronic sequelae of non-A, non-B hepatitis. Ann of Intern Med 91:1–6.

    CAS  Google Scholar 

  14. Blattner, W.A., D.W. Blayney, MR. Guroff, M.G. Sarngadharan, V.S. Kalyanaraman, P.S. Sarin, E.S. Jaffe, and R.C. Gallo. 1983. Epidemiology of Human T-Cell Leukemia/Lymphoma Virus. J of Inf Dis 147:406–416.

    Article  CAS  Google Scholar 

  15. Bradley, D.W., J.E. Maynard, H. Popper, E.H. Cook, J.W. Ebert, K.A. McCaustland, C.A. Schable, and H.A. Fields. 1983. Posttransfusion non-A, non-B hepatitis: Physicochemical properties of two distinct agents. J of Inf Dis 148:254–265.

    Article  CAS  Google Scholar 

  16. Braine, H.G., T.S. Kickler, P. Charache, P.M. Ness, J. Davis, C. Reichart, and A.K. Fuller. 1986. Bacterial sepsis secondary to platelet transfusion: an adverse effect of extended storage at room temperature. Transfusion 26:391–393.

    Article  PubMed  CAS  Google Scholar 

  17. Burke, D.S., B.L. Brandt, R.R. Redfield, T.H. Lee, R.M Thorn, G.A. Beltz, and C.H. Hung. 1987. Diagnosis of human immunodeficiency virus infection by immunoassay using a molecularly cloned and expressed virus envelope polypeptide. Comparison to Western blot on 2707 consecutive serum samples. Ann Intern. Med 106:671–676.

    PubMed  CAS  Google Scholar 

  18. Burke, D.S., J.F. Brundage, J.R. Herbold, W. Berner, L.I. Gardner, J.D. Gunzenhauser, J. Voskovitch, and R.R. Redfield. 1987. Human immunodeficiency virus infections among civilian applicants for United States military service, October 1985 to March 1986. Demographic factors associated with seropositivity. N Eng J Med 317:131–136.

    Article  CAS  Google Scholar 

  19. Carlson, J.R. 1988. Serological diagnosis of human immunodeficiency virus infection by Western blot testing. JAMA 260:674–679.

    Article  Google Scholar 

  20. Carlson, J.R., J. Yee, S.H. Hinrichs, ML. Bryant, MB. Gardner, and N.C. Pedersen. 1987. Comparison of indirect immunofluorescence and Western blot for detection of anti-human immunodeficiency virus antibodies. J Clin. Microbiol 25:494–497.

    PubMed  CAS  Google Scholar 

  21. CDC 1987. Human immunodeficiency virus infection in the United States: A review of current knowledge. MMWR 26(Supplement S6):1–48.

    Google Scholar 

  22. CDC 1988. Licensure of screening tests for antibody to human T-lymphotropic virus type I. MMWR 37:736–745.

    Google Scholar 

  23. CDC 1988. Yersinia enterocolitica bacteremia and endotoxin shock associated with red blood cell transfusion-United States, 1987–1988. MMWR 37:577–578.

    Google Scholar 

  24. CDC 1988. Safety of therapeutic products used for hemophilia patients. MMWR 37:441–450.

    Google Scholar 

  25. CDC 1989. Risks associated with human parvovirus B19 infection. MMWR 38:81–97.

    Google Scholar 

  26. Curran, J.W., H.W. Jaffe, A.M Hardy, W.M Morgan, R.M. Selik, and T.J. Dondero. 1988. Epidemiology of HIV infection and AIDS in the United States. Science 239:610–616.

    Article  PubMed  CAS  Google Scholar 

  27. Dienstag, J.L. 1983. Non-A, non-B hepatitis. II. Experimental transmission, putatitve virus agents and markers, and prevention. Gastroenterol 85:743–768.

    CAS  Google Scholar 

  28. Dienstag, J.L. 1983. Non-A, non-B hepatitis. I. Recognition, epidemiology, and clinical features. Gastroenterol 85:439–462.

    CAS  Google Scholar 

  29. Dock, N.L., H.V. Lamberson, Jr., T.A. O’Brien, D.E. Tribe, S.S. Alexander, and B.J. Poiesz. 1988. Evaluation of atypical human immunodeficiency virus immunoblot reactivity in blood donors. Transfusion 28:412–418.

    Article  PubMed  CAS  Google Scholar 

  30. Dodd, R.Y. 1985. Donor screening and epidemiology, p.389–405. In R.Y. Dodd, and L.F. Barker (eds.), Infection, Immunity, and Blood Transfusion. Alan R. Liss, New York.

    Google Scholar 

  31. Dodd, R.Y., and N. Nath. 1987. Increased risk for lethal forms of liver disease among HBsAg-positive blood donors in the U.S. J of Vir Meth 17:81–94.

    Article  CAS  Google Scholar 

  32. Farzadegan, H., M.A. Polis, S.M Wolinsky, C.R. Rinaldo, J.J. Sninsky, S. Kwok, R.L. Griffith, R.A. Kaslow, J.P. Phair, F. Polk, and A.J. Saah. 1988. Loss of human immunodeficiency virus type 1 (HIV-1) antibodies with evidence of viral infection in asymptomatic homosexual men. Ann of Intern Med 108:785–790.

    CAS  Google Scholar 

  33. Gallo, R.C., S.Z. Salahuddin, M Popovic, G.M Shearer, M Kaplan, B.F. Haynes, T.J. Palker, R. Redfield, J. Oleske, B. Safai, G. White, P. Foster, and P.D. Markham. 1984. Frequent detection and isolation of cytopathic retroviruses (HTLV-III) from patients with AIDS and at risk for AIDS. Science 224:500–503.

    Article  PubMed  CAS  Google Scholar 

  34. Gomperts, E.D. 1986. Procedures for the inactivation of viruses in clotting factor concentrates. Am J Hematol. 23:295–305.

    Article  PubMed  CAS  Google Scholar 

  35. Goudsmit, J., F. DeWolf, D.A. Paul, L.G. Epstein, J.MA. Lange, W.J.A. Krone, H. Speelman, E.G. Wolters, J. van der Noorda, J.M Oleske, H.J. van der Helm, and R.A. Coutinho. 1986. Expression of human immunodeficiency virus antigen (HIV-Ag) in serum and cerebrospinal fluid during acute and chronic infection. Lancet 2:177–180.

    Article  PubMed  CAS  Google Scholar 

  36. Grindon, A.J., S.E. Critchley, and J.W. Ward. 1988. Risk of HIV infection in recipients of untested blood from donors now anti-HIV-positive. Transfusion 28:419–421.

    Article  PubMed  CAS  Google Scholar 

  37. Handsfield, H.H., M Wandell, L. Goldstein, and K. Shriver. 1987. Screening and diagnostic performance of enzyme immunoassay for antibody to lymphadenopathy-associated virus. J. Clin. Microbiol. 25:879–884.

    PubMed  CAS  Google Scholar 

  38. Heal, J.M., ME. Jones, J. Forey, A. Chaudry, and R.L. Stricoff. 1987. Fatal Salmonella septicemia after platelet transfusion. Transfusion 27:2–5.

    Article  PubMed  CAS  Google Scholar 

  39. Henle, W., and G. Henle. 1985. Epstein-Barr virus and blood transfusions, p. 201–209. In R.Y. Dodd, and L.F. Barker (eds.), Infection, Immunity, and Blood Transfusion. Alan R. Liss, New York.

    Google Scholar 

  40. Hoff, R., V.P. Berardi, B.J. Weiblen, L. Mahoney-Trout, ML. Mitchell, and G.F. Grady. 1988. Seroprevalence of human immunodeficiency virus among childbearing women. Estimation by testing samples of blood from newborns. N. Engl. J Med. 318:525–530.

    Article  PubMed  CAS  Google Scholar 

  41. Holland, P.V. 1988. Why a new standard to prevent Creutzfeldt-Jakob disease. Transfusion 28:293–294.

    Article  PubMed  CAS  Google Scholar 

  42. Hollinger, F.B., N.C. Khan, P.E. Oefinger, D.H. Yawn, A.C. Schmulen, G.R. Dreesman, and J.L. Melnick. 1983. Posttransfusion hepatitis type A. JAMA 250:2313–2317.

    Article  PubMed  CAS  Google Scholar 

  43. Kleinman, S., and K. Secord. 1988. Risk of human immonodeficiency virus (HIV) transmission by anti-HIV negative blood. Estimates using the lookback methodology. Transfusion 28:499–501.

    Article  PubMed  CAS  Google Scholar 

  44. Koziol, D.E., P.V. Holland, D.W. Ailing, J.C. Melpolder, R.E. Solomon, R.H. Purcell, L.M. Hudson, F.J. Shoup, H. Krakauer, and H.J. Alter. 1986. Antibody to hepatitis B core antigen as a paradoxical marker for non-A, non-B hepatitis agents in donated blood. Ann of Intern Med 104:488–495.

    CAS  Google Scholar 

  45. Kuhnl, P., S. Seidl, and G. Holzberger. 1985. HLA Dr4 antibodies cause positive HTLV III antibody ELISA results. Lancet 1:1222–1223.

    Article  PubMed  CAS  Google Scholar 

  46. Kuritsky, J.N., S.C. Rastogi, G.A. Faich, J.B. Schorr, J.E. Menitove, R.W. Reilly, and J.R. Bove. 1986. Results of nationwide screening of blood and plasma for antibodies to human T-cell lymphotropic III virus, type III. Transfusion 26:205–207.

    Article  PubMed  CAS  Google Scholar 

  47. Lamberson, H.V., J.A. McMillan, L.B. Weiner, M.L. Williams, D.A. Clark, C.A. McMahon, E.B. Lentz, A.P. Higgins, and N.L. Dock. 1988. Prevention of transfusion-associated cytomegalovirus (CMV) infection in neonates by screening blood donors for IgM to CMV. J of Inf Dis 157:820–823.

    Article  Google Scholar 

  48. Lentz, E.B., N.L. Dock, C.A. McMahon, S.R. Fiesthumel, C.B. Arnold, and H.V. Lamberson. 1988. Detection of antibody to CMV-induced early antigens and comparison with four serologic assays and presence of viruria in blood donors. J of Clin Microbiol 26:133–135.

    CAS  Google Scholar 

  49. Levy, J.A., A.D. Hoffman, S.M Kramer, J.A. Landis, J.M. Shimabukuro, and L.S. Oshiro. 1984. Isolation of lymphocytoathic retroviruses from San Francisco patients with AIDS. Science 225:840–842.

    Article  PubMed  CAS  Google Scholar 

  50. Mannucci, P.M., and M Colombo. 1988. Virucidal treatment of clotting factor concentrates. Lancet 2:782–784.

    Article  PubMed  CAS  Google Scholar 

  51. Minamoto, G.Y., J.W.M. Gold, D.A. Scheinberg, W.D. Hardy, N. Chein, E. Zuckerman, L. Reich, K. Dietz, T. Gee, J. Hoffer, K. Mayer, J. Gabrilove, B. Clarkson, and D. Armstrong. 1988. Infection with human T-cell leukemia virus type I in patients with leukemia. N Eng J Med 318

    Google Scholar 

  52. Mosley, J.W., A.G. Redeker, S.M Feinstone, and R.H. Purcell. 1977. Multiple hepatitis viruses in multiple attacks of acute viral hepatitis. N Eng J Med 296:75–78.

    Article  CAS  Google Scholar 

  53. Noble, R.C., M.A. Kane, S.A. Reeves, and I. Roeckel. 1984. Posttransfusion hepatitis A in a neonatal intensive care unit. JAMA 252:2711–2715.

    Article  PubMed  CAS  Google Scholar 

  54. Okochi, K., and H. Sato. 1986. Transmission of adult T-cell leukemia virus (HTLV-1) through blood transfusion and its prevention. AIDS Res 2:S157–S161.

    Article  PubMed  Google Scholar 

  55. Okochi, K., H. Sato, and Y. Hinuma. 1984. A retrospective study on transmission of adult T-cell leukemia virus by blood transfusion: Seroconversion in recipients. Vox Sang 46:245–253.

    Article  PubMed  CAS  Google Scholar 

  56. Peterman, T.A., K.-J. Lui, D.N. Lawrence, and J.R. Allen. 1987. Estimating the risks of transfusion-associated acquired immune deficiency syndrome and human immunodeficiency virus infection. Transfusion 27:371–374.

    Article  PubMed  CAS  Google Scholar 

  57. Peterman, T.A., R.L. Stoneburner, J.R. Allen, H.W. Jaffe, and J.W. Curran. 1988. Risk of human immunodeficiency virus transmission from heterosexual adults with transfusion-associated infections. JAMA 259:55–58.

    Article  PubMed  CAS  Google Scholar 

  58. Poiesz 1980. Detection and isolation of type C retroviruses particles from fresh and cultured lymphocytes of a patient with cutaneous T-cell lymphoma. Proc Natl Acad Sci Vol 77, No 12:7415–7419.

    Article  PubMed  CAS  Google Scholar 

  59. Popovsky, M.A., L.E. Lindberg, A.L. Syrek, and P.L. Page. 1988. Prevalence of Babesia antibody in a selected blood donor population. Transfusion 28:59–61.

    Article  PubMed  CAS  Google Scholar 

  60. Robert-Guroff, M, S. Weiss, J. Giron, A.M Jennings, H.M. Ginzburg, I.B. Margolis, W.A. Blattner, and R.C. Gallo. 1986. Prevalence of antibodies to HTLV-I,-II, and-III in intravenous drug abusers from an AIDS endemic region. JAMA 255:3133–3137.

    Article  PubMed  CAS  Google Scholar 

  61. Robert-Guroff, M, S.H. Weiss, J.A. Giron, A.M Jennings, H.M. Ginzburg, I.B. Margolis, W.A. Blattner, and R.C. Gallo. 1986. Prevalence of antibodies to HTLV-I,-II, and-III in intravenous drug abusers from an AIDS endemic region. JAMA 255:3133–3137.

    Article  PubMed  CAS  Google Scholar 

  62. Roman, G.C. 1987. Retrovirus-associated myelopathies. Arch Neurol 44:659–663.

    Article  PubMed  CAS  Google Scholar 

  63. Rosenblatt, J.D., I.S.Y. Chen, and W. Wachsman. 1988. Infection with HTLV-I and HTLV-II: Evolving concepts. Semin. Hematol. 25:230–246.

    PubMed  CAS  Google Scholar 

  64. Saah, A.J., H. Farzadegan, R. Fox, P. Nishanian, C.R. Rinaldo, J.P. Phair, J.L. Fahey, T.H. Lee, B.F. Polk, and The Multicenter AIDS Cohort Study. 1987. Detection of early antibodies in HIV infection by enzyme-linked immunosorbent assay, western blot, and radioimmunoprecipitation. J of Clin Microbiol 25:1605–1610.

    CAS  Google Scholar 

  65. Salahuddin, S.Z., D.V. Ablashi, P.D. Markham, S.F. Josephs, S. Sturzenegger, M. Kaplan, G. Halligan, P. Biberfeld, F.W. Staal, B. Kramarsky, and R.C. Gallo. 1986. Isolation of a new virus, HBLV, in patients with lymphoproliferative disorders. Science 234:596–600.

    Article  PubMed  CAS  Google Scholar 

  66. Sarngadharan, M.G., M Popovic, L. Bruch, J. Schupbach, and R.C. Gallo. 1984. Antibodies reactive with human T-lymphotropic retroviruses (HTLV-III) in the serum of patients with AIDS. Science 224:506–508.

    Article  PubMed  CAS  Google Scholar 

  67. Sayers, M.H., P.G. Beatty, and J.H. Hansen. 1986. HLA antibodies as a cause of false-positive reactions in screening enzyme immunoassays for antibodies to human T-lymphotropic virus type III. Transfusion 26:113–115.

    Article  PubMed  CAS  Google Scholar 

  68. Schorr, J.B., A. Berkowitz, P.D. Cumming, A.J. Katz, and S.G. Sandier. 1985. Prevalence of HTLV-III antibody in American blood donors. N Eng J Med 313:384–385.

    Article  CAS  Google Scholar 

  69. Stevens, C.E., R.D. Aach, F.B. Hollinger, J.W. Mosley, W. Szmuness, R. Kahn, J. Werch, and V. Edwards. 1984. Hepatitis B virus antibody in blood donors and the occurrence of Non-A, non-B hepatitis in transfusion recipients. An analysis of the Transmission-Transmitted Viruses Study. Ann of Intern Med 101:733–738.

    CAS  Google Scholar 

  70. Swenson, S. 1987. Syphilis serology, cytomegalovirus testing and alanine aminotransferase testing, p. 51–90. In M.R. Dixon, and S.S. Ellisor (eds.), Selection of Methods and Instruments for Blood Banks. American Association of Blood Banks, Arlington, VA.

    Google Scholar 

  71. Tabor, E., J.H. Hoofnagle, L.F. Barker, G. Tamondong-Pineda, N. Nath, L.A. Smallwood, and R.J. Gerety. 1981. Antibody to hepatitis B core antigen in blood donors with a history of hepatitis. Transfusion 21:366–371.

    Article  PubMed  CAS  Google Scholar 

  72. Tabor, E., D.R. Jackson, Z. Schaff, P.M. Blatt, and R.J. Gerety. 1984. Additional evidence for more than one agent of human non-A, non-B hepatitis. Transmission and passage studies in chimpanzees. Transfusion 24:224–230.

    Article  PubMed  CAS  Google Scholar 

  73. Tegtmeier, G.E. 1985. Cytomegalovirus and blood transfusion, p.175–199. In R.Y. Dodd, and L.F. Barker (eds.), Infection, Immunity, and blood transfusion. Alan R. Liss, New York.

    Google Scholar 

  74. Tegtmeier, G.E. 1987. Blood transfusion and the transmission of cytomegalovirus, p.87–118. In S.B. Moore (ed.), Transfusion-Transmitted Viral Diseases. American Association of Blood Banks, Arlington, VA.

    Google Scholar 

  75. Walker, R.H. 1965. The disposition of STS reactive blood in a transfusion service. Transfusion 5:452–456.

    Article  PubMed  CAS  Google Scholar 

  76. Wang, J.J.G., S. Steel, R. Wisniewolski, and C.Y. Wang. 1986. Detection of antibodies to human T-lymphotropic virus type III by using a synthetic peptide of 21 amino acid residues corresponding to a highly antigenic segment of gp41 envelope protein. Proc Natl Acad Sci USA 83:6159–6163.

    Article  PubMed  CAS  Google Scholar 

  77. Ward, J.W., D.A. Deppe, S. Samson, H. Perkins, P. Holland, L. Fernando, P.M. Feorino, P. Thompson, S. Kleinman, and J.R. Allen. 1987. Risk of human immunodeficiency virus infection from blood donors who later developed the acquired immunodeficiency syndrome. Ann of Intern Med 106:61–62.

    CAS  Google Scholar 

  78. Ward, J.W., A.J. Grindon, P.M. Feorino, C. Schable, M Parvin, and J.R. Allen. 1986. Laboratory and epidemiologic evaluation of an enzyme immunoassay for antibodies to HTLV-III. JAMA 256:357–361.

    Article  PubMed  CAS  Google Scholar 

  79. Ward, J.W., S.D. Holmberg, J.R. Allen, D.L. Cohn, S.E. Critchley, S.H. Klcinman, B.A. Lenes, O. Ravenholt, J.R. Davis, M.G. Quinn, and a. l. et. 1988. Transmission of human immunodeficiency virus (HIV) by blood transfusions screened as negative for HIV antibody. N. Engl. J. Med. 318:473–478.

    Article  PubMed  CAS  Google Scholar 

  80. Williams, A.E., CT. Fang, D.J. Slamon, B.J. Poiesz, S.G. Sandler, W.F. Darr, G. Shulman, E.I. McGowan, D.K. Douglas, R.J. Bowman, F. Peetoom, S.H. Kleinman, B. Lenes, and R.Y. Dodd. 1988. Seroprevalence and epidemiological correlates of HTLV-1 infection in U.S. blood donors. Science 240:643–646.

    Article  PubMed  CAS  Google Scholar 

  81. Winston, D.J., W.G. Ho, L. Cheng-Hsien, K. Bartoni, MD. Budinger, R.P. Gale, and R.E. Champlin. 1987. Intravenous immune globulin for prevention of cytomegalovirus infection and interstitial pneumonia after bone marrow transplantation. Ann of Intern Med 106:12–18.

    CAS  Google Scholar 

  82. Wolinsky, S., C. Rinaldo, H. Farzadegan, P. Gupta, R. Kaslow, D. Immagawa, J. Chmiel, J., Phair, J. Kwok, and J. Sninsky. 1988. Polymerase chain reaction (PCR) detection of HIV provirus before HIV seroconversion. Abstracts: IV International Conference on AIDS. 1:137.(Abstract)

    Google Scholar 

  83. Yeager 1983. Sequelae of maternally derived cytomegalovirus infections in premature infants. J of Pediatrics. 102:918–922.

    Article  CAS  Google Scholar 

  84. Zuck, T.F. 1987. Greetings — a final look back with comments about a policy of a zero-risk blood supply. Transfusion 27:447–448.

    Article  PubMed  CAS  Google Scholar 

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Authors and Affiliations

  1. Jerome H. Holland Laboratory, American Red Cross, 15601 Crabbs Branch Way, Rockville, MD, 20855, USA

    Roger Y. Dodd

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Editors and Affiliations

  1. School of Medicine Temple University, Philadelphia, Pennsylvania, USA

    Kenneth R. Cundy Ph.D. (Chairman) (Chairman)

  2. Pennsylvania Department of Health, Lionville, Pennsylvania, USA

    Bruce Kleger Dr.P.H. (Co-Chairmen) (Co-Chairmen)

  3. United Hospitals, Inc., Philadelphia, Pennsylvania, USA

    Eileen T. Hinks Ph.D. (Co-Chairmen) (Co-Chairmen)

  4. Holy Redeemer Hospital and Medical Center, Meadowbrook, Pennsylvania, USA

    Linda A. Miller Ph.D.

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Dodd, R.Y. (1990). How Safe is the Blood Supply in the United States?. In: Cundy, K.R., Kleger, B., Hinks, E.T., Miller, L.A. (eds) Infection Control. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-5724-7_6

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