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Carnitine Supplementation in Uremia

  • Conference paper
New Perspectives in Hemodialysis, Peritoneal Dialysis, Arteriovenous Hemofiltration, and Plasmapheresis

Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 260))

Abstract

In humans, L-carnitine (L- (-) -3-hydroxy-4-trimethylaminobutyrate, molecular weight 62 daltons) is synthesized in the liver, kidney and brain from the two essential amino acids lysine and methionine mediated by a multi-enzyme system1. Four co-factors — vitamin C, niacin, vitamin B6, and iron — are required by the various enzymes2 , 3 . The rare amino acid N-6-trimethyllysine (TML) is formed by posttranslational methylation of lysine residues with S-adenosylmethionine4. Once released by proteolytic action, it may serve as a precursor for the endogenous biosynthesis of carnitine5 . TML is converted to L-carnitine via four enzymatic steps (hydroxylation, aldol cleavage, oxidation and a second hydroxylation).

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Author information

Authors and Affiliations

  1. Institut für Biologische Chemie und Ernährungswissenschaft, Universität Hohenheim, D-7000, Stuttgart 70, Deutschland

    Peter Fürst, Anne Glöggler & Claudia Rössle

  2. Laboratoire de Nutrition, Hopital St. Pierre, B-1000, Bruxelles, Belgium

    Claudia Rössle

Authors
  1. Peter Fürst
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  2. Anne Glöggler
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  3. Claudia Rössle
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Editor information

Editors and Affiliations

  1. Medizinische Universitätsklinik, Freiburg, Federal Republic of Germany

    W. H. Hörl  & P. J. Schollmeyer  & 

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© 1989 Plenum Press, New York

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Fürst, P., Glöggler, A., Rössle, C. (1989). Carnitine Supplementation in Uremia. In: Hörl, W.H., Schollmeyer, P.J. (eds) New Perspectives in Hemodialysis, Peritoneal Dialysis, Arteriovenous Hemofiltration, and Plasmapheresis. Advances in Experimental Medicine and Biology, vol 260. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-5718-6_8

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  • DOI: https://doi.org/10.1007/978-1-4684-5718-6_8

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4684-5720-9

  • Online ISBN: 978-1-4684-5718-6

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