Abstract
The peritoneal cavity is lined by a membrane consisting of a single layer of mesothelial cells resting on a thin basement membrane; underneath the mesothelial cell layer loose connective tissues contain the capillaries that are essential for dialysis. The mesothelial cell layer is rather unique, it is of mesodermal origin and covers the large body cavities. Morphologic studies have shown that mesothelial cells have microvilli on their apical surface and that their surfaces are covered with slippery glycocalix1,2.
Keywords
- Peritoneal Dialysis
- Mesothelial Cell
- Peritoneal Membrane
- Chronic Peritoneal Dialysis
- Peritoneal Dialysis Fluid
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.
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References
R. S. Cunningham, The physiology of the serous membrane, Physiol. Rev. 6:242–277 (1926).
P. M. Andrews and K. R. Porter, The ultrastructural morphology and pos-sible functional significance of mesothelial microvilli, Anat. rec. 177:409–426 (1974).
G. E. Digenis, S. Rabinovich, A. Medline, H. Rodella, G. Wu, and D. G. Oreopoulos, Electron microscopic study of the peritoneal kinetics of iron dextran during peritoneal dialysis in the rabbit, Nephron. 37:108–112 (1984).
L. J. Nicholson, J. M. F. Clarke, R. M. Pittilo, S. J. Machin, and N. Woolf, The mesothelial cell as a non-thrombogenic surface, Thromb. Haemostas. 37:108–112 (1984).
N. Di Paolo, G. Sacchi, M. De Mia, et al., Morphology of the peritoneal membrane during continuous ambulatory peritoneal dialysis, Nephron. 44:204–211 (1986).
J. W. Dobbie and M. A. Zaki, The ultrastructure of the parietal peritoneum in normal and uraemic man and in patients on. CAPD. In: “Frontiers in peritoneal dialysis”J. F. Maher and J. F. Winchester, ed., Rich & Assoc, New York (1986).
C. Verger, A. Luger, H. L. Moore, and K. D. Nolph, Acute changes in peritoneal morphology and transport properties with infectious peritonitis and mechanical injury, Kidney Int. 23:823–831 (1983).
Y. J. Wu, L. M. Parker, N. E. Binder, et al, The mesothelial keratins: a new family of cytoskeletal proteins identified in cultured mesothelial cells and nonkeratinizing epithelia. Cell. 31:693–703 (1982).
P. J. Romano, Cytolytic assays for soluble antigens, in: “Manual of clinical laboratory immunology”, N. R. Rose, H. Friedman, J. L. Fahey, ed., ASM, Washington DC (1986).
H. A. Verbrugh, R. P. Verkooijen, J. Verhoef, P. L. Oe, J. van der Meulen, Defective complement-mediated opsonization and lysis of bacteria in commercial peritoneal dialysis solutions, in: “Frontiers in peritoneal dialysis”, J. F. Mäher, J. F. Winchester, ed., Rich & Assoc, New York (1986).
A. K. Duwe, S. I. Vas, and J. W. Weatherheard, Effects of composition of peritoneal dialyis fluid on chemiluminescence, phagocytosis, and bactericidal activity in vitro, Infect. Immun.33:130–135 (1981).
M. Lorenzi, D. F. Montisano, and S. Toledo, High glucose induces DNA damage in cultured human endothelial cells, Barrieux. J. Clin. Invest. 77:322–325 (1986).
M. C. Coene, C. Solheid, M. Claeys, and A. G. Herman, Prostaglandin procuction by cultured mesothelial cells, Arch. Int. Pharmacodyn. 249:316–318 (1981).
J. O. Cantor, M. Willhite, B. A. Bray, S. Keller, I. Mandl, and G. M. Turino, Synthesis of crosslinked elastin by a mesothelial cell culture (42269), Proc. Soc. Exp. Biol. Med. 181:387–391 (1986).
W. Harvey and P. L. Amlot, Collagen production by human mesothelial cells in vitro, J. Pathol. 139:337–347 (1983).
M. Rogolsky, Nonenteric toxins of Staphylococcus aureus, Microbiol. Rev. 43:320–360 (1979).
C. G. Gemmell, Virulence characteristics of Staphylococcus epidermidis, J. Med. Microbiol. 22:289–291 (1986).
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© 1989 Plenum Press, New York
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Verbrugh, H.A. (1989). The Biology of the Peritoneal Membrane During Chronic Peritoneal Dialysis. In: Hörl, W.H., Schollmeyer, P.J. (eds) New Perspectives in Hemodialysis, Peritoneal Dialysis, Arteriovenous Hemofiltration, and Plasmapheresis. Advances in Experimental Medicine and Biology, vol 260. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-5718-6_13
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DOI: https://doi.org/10.1007/978-1-4684-5718-6_13
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