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Loss of Suppressor-inducer T-Cells in Chronic-progressive Multiple Sclerosis: Preliminary Results

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Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 257))

Abstract

Multiple Sclerosis (MS) has long been postulated to be an autoimmune disease of the Central Nervous System with a possible viral origin and with relevant abnormalities in immunoregulation (1). The most important immunological finding in MS is a defective T-suppressor activity which is proven by functional assays as by phenotypic characterization (2).

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References

  1. B.H. Waksman and W.E. Reynolds, Multiple Sclerosis as a disease of immunoregulation, Proc.Soc.Exp.Biol.Med. 175:282 (1984).

    PubMed  CAS  Google Scholar 

  2. B.G.W. Arnason, Immunocyte abnormalities in multiple sclerosis, in: “Virology and immunology of multiple sclerosis: rationale for therapy” C.L. Cazzullo, D.Caputo, A.Ghezzi and M.Zaffaroni Eds., Springer-Verlag, Berlin (1988).

    Google Scholar 

  3. M.A. Bach et al., Deficit of suppressor T-cells in active multiple sclerosis, Lancet 2:1221 (1980).

    Article  PubMed  CAS  Google Scholar 

  4. E.L. Reinherz et al., Loss of suppressor T-cells in active multiple sclerosis: analysis with monoclonal antibodies, N.Engl.J.Med. 303: 125 (1980).

    Article  PubMed  CAS  Google Scholar 

  5. A. Compston, Lymphocyte subpopulations in patients with multiple sclerosis, J.Neurol.Neurosurg.Psych. 46:105 (1983).

    Article  CAS  Google Scholar 

  6. M.Zaffaroni et al., Monoclonal antibody analysis of blood T-cell subsets in multiple sclerosis, Ital.J.Neurol.Sci. 5:45 (1984).

    Article  PubMed  CAS  Google Scholar 

  7. C. Morimoto et al., Selective loss of the suppressor-inducer T-cell subset in progressive multiple sclerosis, N.Engl.J.Med. 316:67 (1987).

    Article  PubMed  CAS  Google Scholar 

  8. C.L. Cazzullo et al., The role of lymphocyte subset analysis in defining the clinical evolution of multiple sclerosis, Europ.Neurol. 27:5 (1987).

    Article  PubMed  CAS  Google Scholar 

  9. H. Koprowsky et al., Multiple sclerosis and human T-cell lymphotropic retroviruses, Nature 318:154 (1985).

    Article  Google Scholar 

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© 1989 Plenum Press, New York

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Zaffaroni, M., Rossini, S., Palma, R., Ghezzi, A., Marforio, S., Cazzullo, C.L. (1989). Loss of Suppressor-inducer T-Cells in Chronic-progressive Multiple Sclerosis: Preliminary Results. In: Askonas, B.A., Moss, B., Torrigiani, G., Gorini, S. (eds) The Immune Response to Viral Infections. Advances in Experimental Medicine and Biology, vol 257. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-5712-4_32

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  • DOI: https://doi.org/10.1007/978-1-4684-5712-4_32

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4684-5714-8

  • Online ISBN: 978-1-4684-5712-4

  • eBook Packages: Springer Book Archive

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