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Pathogenesis of Dengue Haemorrhagic Fever: Current Perspectives

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The Immune Response to Viral Infections

Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 257))

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Abstract

Dengue viruses belong to the family Flaviviridae and the four recognized serotypes (dengue-1, dengue-2, dengue-3, dengue-4) cause a spectrum of disease ranging from an undif-ferentiated febrile illness to the severe, life-threatening dengue haemorrhagic fever/dengue shock syndrome (DHF/DSS). DHF/DSS remains as a major public health problems in various parts of Southeast Asia, the Pacific region and, more recently, the Caribbean. The disease syndromes pose special problems for health authorities because of their epidemic potential, the often high case-fatality rate and difficulties associated with treatment and prevention. As part of the overall effort at disease control and prevention, a comprehensive understanding of the pathogenesis of DHF/DSS is vital in the quest for more rational approaches to treatment and the design of appropriate and effective vaccines.

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Authors and Affiliations

  1. Department of Medical Microbiology, University of Malaya, 59100, Kuala Lumpur, Malaysia

    Tikki Pang

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  1. Tikki Pang
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Editors and Affiliations

  1. National Institute for Medical Research, London, UK

    B. A. Askonas

  2. National Institutes of Health, Bethesda, Maryland, USA

    B. Moss

  3. World Health Organization, Geneva, Switzerland

    G. Torrigiani

  4. Fondazione Internazionale Menarini, Florence, Italy

    S. Gorini

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© 1989 Plenum Press, New York

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Pang, T. (1989). Pathogenesis of Dengue Haemorrhagic Fever: Current Perspectives. In: Askonas, B.A., Moss, B., Torrigiani, G., Gorini, S. (eds) The Immune Response to Viral Infections. Advances in Experimental Medicine and Biology, vol 257. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-5712-4_15

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  • DOI: https://doi.org/10.1007/978-1-4684-5712-4_15

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