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Molecular and Genetic Aspects of the Immune Responses to Hepatitis B Viral Antigens

  • Conference paper
The Immune Response to Viral Infections

Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 257))

Summary

In the absence of an inbred animal model of hepatitis B virus (HBV) infection, several laboratories have chosen to study the murine immune response to HBV-encoded proteins as immunogens as opposed to an infectious agent. This article reviews the immunogenicity, the fine specificity of T and B cell recognition of HBV antigens, and the genetic influences that regulate these responses. It is anticipated that this approach will increase our understanding of immune-mediated viral clearance mechanisms during HBV infection, and may provide the framework for the design of second and third generation HBV vaccines.

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Authors and Affiliations

  1. Department of Molecular Biology, Research Institute of Scripps Clinic, La Jolla, California, USA, 92037

    David R. Milich

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  1. David R. Milich
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Editors and Affiliations

  1. National Institute for Medical Research, London, UK

    B. A. Askonas

  2. National Institutes of Health, Bethesda, Maryland, USA

    B. Moss

  3. World Health Organization, Geneva, Switzerland

    G. Torrigiani

  4. Fondazione Internazionale Menarini, Florence, Italy

    S. Gorini

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© 1989 Plenum Press, New York

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Milich, D.R. (1989). Molecular and Genetic Aspects of the Immune Responses to Hepatitis B Viral Antigens. In: Askonas, B.A., Moss, B., Torrigiani, G., Gorini, S. (eds) The Immune Response to Viral Infections. Advances in Experimental Medicine and Biology, vol 257. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-5712-4_12

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  • DOI: https://doi.org/10.1007/978-1-4684-5712-4_12

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4684-5714-8

  • Online ISBN: 978-1-4684-5712-4

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