Skip to main content
SpringerLink
Log in

Prostaglandins, Thromboxane and Leukotrienes in the Control of Mesangial Function

  • Chapter
Renal Eicosanoids

Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 259))

Abstract

Mesangial cells are intercapillary cells of the kidney glomerulus, serving both smooth muscle and immune effector functions (1–3). Since the first report of contraction of cultured rat mesangial cells by the vasoactive peptides, angiotensin II (ANG II) and arginine vasopressin (AVP) (2,4), considerable interest focused on the hypothesis that mesangial cells may regulate glomerular blood flow and filtration in synergism with afferent and efferent resistances, by altering capillary surface area and hence the ultrafiltration coefficient, Kf (5,6). Changes of capillary surface area might result from mechanical stretching and constriction of vessel walls by surrounding mesangial cells or intraglomerular shunting of blood flow as a result of segmental occlusion of certain loops. Although no definitive evidence of such function has been provided thus far, a number of observations link the mesangial cell to a regulatory role on glomerular hemodynamics, including reports of selective changes of Kf upon induction of glomerular immune injury (7) or infusion of vasoactive agents (8–10). Further support to the concept of mechanical properties of the mesangium comes from studies in freshly isolated rat and human glomeruli, which are rapidly contracted by ANG II, as evaluated by different techniques (11,12).

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Log in via an institution
eBook
USD 16.99
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 109.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. J.I. Kreisberg, M. Venkatachalam, D. Troyer, Contractile properties of cultured glomerular mesangial cells, Am. J. Physiol. 249 (Renal Fluid Electrolyte Physiol 18):F457–F463 (1985).

    CAS  PubMed  Google Scholar 

  2. P.R. Mahieu, J.B. Foidart, C.H. Dubois, C.A. Dechenne, J. Deheneffe, Tissue culture of normal rat glomeruli: contractile activity of the cultured mesangial cells, Invest. Cell Pathol. 3:121–128 (1980).

    CAS  Google Scholar 

  3. G.E. Striker and L.J. Striker, Biology of disease: glomerular cell culture, Lab. Invest. 53:122–131 (1985).

    CAS  Google Scholar 

  4. D.A. Ausiello, J.I. Kreisberg, C. Roy, M.J. Karnovski, Contraction of cultured rat glomerular cells of apparent mesangial origin after stimulation with angiotensin II and arginine vasopressin, J. Clin. Invest. 65:754–760 (1980).

    Article  CAS  PubMed  Google Scholar 

  5. B.M. Brenner, L.D. Dworken, I. Ichikawa, Glomerular ultrafiltration, in: “The Kidney”, B.M. Brenner, F.C. Rector, eds., Philadelphia, W.B. Saunders, pp. 124–144 (1986).

    Google Scholar 

  6. L.A. Scharschmidt, E. Lianos, M.J. Dunn, Arachidonate metabolites and the control of renal function, Federation Proc.42:3058–3063 (1983).

    CAS  Google Scholar 

  7. D.A. Maddox, C.M. Bennett, W.M. Deen, R.J. Glassock, D. Knutson, T.M. Daughterty, B.M. Brenner, Determinants of glomerular filtration in experimental glomerulonephritis in the rat, J. Clin. Invest. 55: 305–318 (1975).

    Article  CAS  PubMed  Google Scholar 

  8. R.C. Blantz, K.S. Konnen, B.J. Tucker, Angiotensin II effects upon the glomerular microcirculation and ultrafiltration coefficient of the rat, J. Clin. Invest. 57:419–434 (1976).

    Article  CAS  PubMed  Google Scholar 

  9. I. Ichikawa and B.M. Brenner, Mechanism of action of histamine and histamine antagonists on the glomerular microcirculation in the rat. Circ. Res. 45:737–745 (1979).

    Article  CAS  PubMed  Google Scholar 

  10. N. Schor, I. Ichikawa, B.M. Brenner, Mechanisms of action of various hormones and vasoactive substances on glomerular ultrafiltration in the rat, Kidney Int. 20:442–451 (1981).

    Article  CAS  PubMed  Google Scholar 

  11. L.A. Scharschmidt, J.G. Douglas, M.J. Dunn, Angiotensin II and eicosanoids in the control of glomerular size in rat and human, Am. J. Phvsiol. 250 (Renal Fluid Electrolyte Physiol.19):F348–F356 (1986).

    CAS  Google Scholar 

  12. V. Savin, In vitro effects of angiotensin II on glomerular function, Am. J. Phvsiol. 251 (Renal Fluid Electrolyte Physiol.20):F627–F634 (1986).

    CAS  Google Scholar 

  13. M.J. Dunn and L.A. Scharschmidt, Prostaglandins modulate the glomerular actions of angiotensin II, Kidney Int. 31 (Suppl.20)S-95–S-101 (1987).

    Google Scholar 

  14. R. Loutzenhiser, M. Epstein, C. Horton, P. Sonke, Reversal of renal and smooth muscle actions of the thromboxane mimetic U-44069 by diltiazem, Am. J. Physiol. 250 (Renal Fluid Electrolyte Physiol. 19):F619–F626 (1986).

    CAS  PubMed  Google Scholar 

  15. L.P. Feigen, B.M. Chapek, J.E. Flemming, J.M. Flemming, P.J. Kadowitz, Renal vascular effects of endoperoxide analogs, prostaglandins and arachidonic acid, Am. J. Physiol. 233 (Heart Circ. Physiol. 1):H573–H579 (1977).

    CAS  PubMed  Google Scholar 

  16. J.G. Gerber, E. Ellis, J. Hollifield, A.S. Nies, Effect of prostaglandin endoperoxide analogues on canine renal function, hemodynamics and renin release, Eur. J. Pharmacol. 53:239–246 (1979).

    Article  CAS  PubMed  Google Scholar 

  17. M. Hamberg, J. Svensson, B. Samuelsson, Thromboxanes: a new group of biologically active compounds derived from prostaglandin endo-peroxides, Proc. Nat. Acad. Sci. USA 72:2994–2998 (1975).

    Article  CAS  PubMed  Google Scholar 

  18. W.A. Scott, J.M. Zrike, A.L. Hamill, J. Kempe, Z.A. Cohn, Regulation of arachidonic acid metabolism in macrophages, J. Exp. Med. 152: 324–355 (1980).

    Article  CAS  PubMed  Google Scholar 

  19. W.A. Scott, N.A. Pawlowski, M. Andreach, Z.A. Cohn, Resting macrophages produce distinct metabolites from exogenous arachidonic acid, J. Exp. Med. 155:535–547 (1982).

    Article  CAS  PubMed  Google Scholar 

  20. E.A. Lianos, G.A. Andres, M.J. Dunn, Glomerular prostaglandin and thromboxane synthesis in rat nephrotoxic serum nephritis. Effects on renal hemodynamics, J. Clin. Invest. 72:1439–1448 (1983).

    Article  CAS  PubMed  Google Scholar 

  21. T. Okegawa, P.E. Jonas, K. DeSchryver, A. Kawasaki, P. Needleman, Metabolic and cellular alterations underlying the exaggerated renal prostaglandin and thromboxane synthesis in ureter obstruction in rabbits, J. Clin. Invest. 71:81–90 (1983).

    Article  CAS  PubMed  Google Scholar 

  22. T.M. Coffman, W.E. Yarger, P.E. Klotman, Functional role of thromboxane production by acutely rejecting renal allografts in rats, J. Clin. Invest. 75:1242–1248 (1985).

    Article  CAS  PubMed  Google Scholar 

  23. C. Patrono, G. Ciabattoni, G. Remuzzi, E. Gotti, S. Bombardieri, O. DiMunno, G. Tartarelli, G.A. Cinotti, B.M. Simonetti, A. Pierucci, Functional significance of renal prostacyclin and thromboxane A2 production in patients with systemic lupus erythematosus, J. Clin. Invest. 76:1011–1018 (1985).

    Article  CAS  PubMed  Google Scholar 

  24. J.I. Kreisberg, M.J. Karnovsky, L. Levine, Prostaglandin production by homogeneous cultures of rat glomerular epithelial and mesangial cells, Kidney Int. 22:355–359 (1982).

    Article  CAS  PubMed  Google Scholar 

  25. L.A. Scharschmidt and M.J. Dunn, Prostaglandin synthesis by rat glomerular mesangial cells in culture, J. Clin. Invest. 71:1756–1764 (1983).

    Article  CAS  PubMed  Google Scholar 

  26. R.A. Lewis and K.F. Austen, The biologically active leukotrienes. Biosynthesis, functions, and pharmacology, J. Clin. Invest. 73:889–897 (1984).

    Article  CAS  PubMed  Google Scholar 

  27. S. Hammarstroem, Leukotrienes, Ann. Rev. Biochem. 52:355–377 (1983).

    Article  CAS  Google Scholar 

  28. E.A. Lianos, M.A. Rahman, M.J. Dunn, Glomerular arachidonate lipoxy-genation in rat nephrotoxic serum nephritis, J. Clin. Invest. 76: 1355–1359 (1985).

    Article  CAS  PubMed  Google Scholar 

  29. J.E. Stork, M.A. Rahman, M.J. Dunn, Eicosanoids in experimental and human renal disease, Am. J. Med. 80(suppl lA):34–45 (1986).

    Article  CAS  PubMed  Google Scholar 

  30. B.J. Ballermann, R.A. Lewis, E.J. Corey, K.F. Austen, B.M. Brenner, Identification and characterization of leukotriene C4 receptors in isolated rat renal glomeruli, Circ. Res. 56:324–330 (1985).

    Article  CAS  PubMed  Google Scholar 

  31. A. Rosenthal, CR. Pace-Asciak, Potent vasoconstriction of the isolated perfused rat kidney by leukotrienes C4 and D4, Can. J. Phvs. Pharmacol. 61:325–328 (1983).

    Article  CAS  Google Scholar 

  32. K. Badr, C. Baylis, J. Pfeffer, M. Pfeffer, R.J. Soberman, R.A. Lewis, K.F. Austen, E.J. Corey, B.M. Brenner, Renal and systemic hemodynamic responses to intravenous infusion of leukotriene C4 in the rat, Circ. Res. 54:492–499 (1984).

    Article  CAS  PubMed  Google Scholar 

  33. S. Bunting, R. Gryglewski, S. Moneada, J.R. Vane, Arterial walls generate from prostaglandin endoperoxides a substance (prostaglandin X) which relaxes strips of mesenteric and coeliac arteries and inhibits platelet aggregation, Prostaglandins 12:897–913 (1976).

    CAS  PubMed  Google Scholar 

  34. B.J.R. Whittle and S. Moncada, Pharmacologic interactions between prostacyclin and thromboxanes, Br. Med. Bull. 39:232–238 (1983).

    CAS  PubMed  Google Scholar 

  35. S. Bunting, S. Moneada, J.R. Vane, The prostacyclin-thromboxane A2 balance: pathophysiological and therapeutic implications, Br. Med. Bull. 39:271–276 (1983).

    CAS  PubMed  Google Scholar 

  36. H. Rasmussen and P.Q. Barrett, Calcium messenger system: an integrated view, Phvsiol. Rev. 64:938–984 (1984).

    CAS  Google Scholar 

  37. M.J. Berridge, Inositol trisphosphate and diacylglycerol as second messengers, Biochem. J. 220:345–360 (1984).

    CAS  PubMed  Google Scholar 

  38. R.S. Adelstein and D.R. Hathaway, Role of calcium and cyclic adenosine 3’:5’ monophosphate in regulating smooth muscle contraction, Am. J. Cardiol. 44:783–787 (1979).

    Article  CAS  PubMed  Google Scholar 

  39. M.S. Simonson and M.J. Dunn, Leukotriene C4 and D4 contract rat glomerular mesangial cells, Kidney Int. 30:524–531 (1986).

    Article  CAS  PubMed  Google Scholar 

  40. P. Mene’ and M.J. Dunn, Contractile effects of TxA2 and endoperoxide analogues on cultured rat glomerular mesangial cells, Am. J. Phvsiol. 251 (Renal Fluid Electrolyte Physiol.20):F1029–F1035 (1986).

    Google Scholar 

  41. R.A. Armstrong, R.L. Jones, V. Peesapati, S.G. Will, N.H. Wilson, Competitive antagonism at thromboxane receptors in human platelets, Br. J. Pharmacol. 84:595–607 (1985).

    Article  CAS  PubMed  Google Scholar 

  42. R.A. Armstrong, R.L. Jones, N.H. Wilson, Ligand binding to thromboxane receptors in human platelets: correlation with biological activity, Br. J. Pharmacol. 79:953–964 (1983).

    Article  CAS  PubMed  Google Scholar 

  43. R. Greenberg, T. Steinbacher, M.F. Haslanger, Thromboxane receptor antagonist properties of SQ 27,427 in the anesthetized guinea pig, Eur. J. Pharmacol. 103:19–24 (1984).

    Article  CAS  PubMed  Google Scholar 

  44. G. Graff, Preparation of PGG2 and PGH2, in: “Methods in Enzymology”, W. Lands, W. Smith, eds., New York, Academic Press, pp. 376–385 (1982).

    Google Scholar 

  45. T. Yoshimoto, S. Yamamoto, M. Okuno, M. Hayaishi, Solubilization and resolution of thromboxane synthesizing systems from microsomes of bovine blood platelets, J. Biol. Chem. 252:5871–5874 (1977).

    CAS  PubMed  Google Scholar 

  46. D. Schlondorff, J.A. Satriano, J. Hagege, J. Perez, L. Baud, Effect of platelet activating factor on prostaglandin E2 synthesis, arachi-donic acid release and contraction of cultured rat mesangial cells, J. Clin. Invest. 73:1227–1231 (1984).

    Article  CAS  PubMed  Google Scholar 

  47. J. Foidart, J. Sraer, F. Delarue, P. Mahieu, R. Ardaillou, Evidence for mesangial glomerular receptors for angiotensin II linked to mesangial contractility, FEBS Lett. 121:333–339 (1980).

    Article  CAS  PubMed  Google Scholar 

  48. T. Tanaka, Y. Fujiwara, Y. Orita, E. Sasaki, H. Kitamura, H. Abe, The functional characteristics of cultured rat mesangial cell, Japn. Circ. J. 48:1017–1029 (1984).

    Article  CAS  Google Scholar 

  49. J.R. Sedor and H.E. Abboud, Histamine modulates contraction and cyclic nucleotides in cultured rat mesangial cells, J. Clin. Invest. 75: 1679–1689 (1985).

    Article  CAS  PubMed  Google Scholar 

  50. P.C. Singhal, L.A. Scharschmidt, N. Gibbons, R.M. Hays, Contraction and relaxation of cultured mesangial cells on a silicone rubber surface, Kidney Int. 30:862–873 (1986).

    Article  CAS  PubMed  Google Scholar 

  51. M.A. Venkatachalam and J.I. Kreisberg, Agonist-induced isotonic contraction of cultured mesangial cells after multiple passage, Am. J. Phvsiol. 249 (Cell Physiol.18):C48–C55 (1985).

    CAS  Google Scholar 

  52. J. Chamley-Campbell, G.R. Campbell, R. Ross, The smooth muscle cell in culture, Phvsiol. Rev. 59:1–61 (1979).

    CAS  Google Scholar 

  53. H.E. Ives, G.S. Schultz, R.E. Galardy, J.D. Jamieson, Preparation of functional smooth muscle cells from the rabbit aorta, J. Exp. Med. 148:1400–1413 (1978).

    Article  CAS  PubMed  Google Scholar 

  54. A.K. Harris, P. Wild, D. Stork, Silicone rubber substrates: a “new wrinkle in the study of locomotion, Science 208:177–179 (1980).

    Article  CAS  PubMed  Google Scholar 

  55. D.E. Mais, D.L. Saussy, Jr., A. Chaikouni, P.J. Kochel, D.R. Knapp, N. Hamanaka, P.V. Halushka, Pharmacologic characterization of human and canine thromboxane A2/prostaglandin H2 receptors in platelets and blood vessels : evidence for different receptors, J. Pharmacol. Exp. Therap. 233:418–424 (1985).

    CAS  Google Scholar 

  56. R. Barnett, P. Goldwasser, L.A. Scharschmidt, D. Schlondorff, Effects of leukotrienes on isolated rat glomeruli and cultured mesangial cells, Am. J. Physiol. 250 (Renal Fluid Electrolyte Physiol. 19): F838–F844 (1986).

    CAS  PubMed  Google Scholar 

  57. J.I. Kreisberg, M.A. Venkatachalam, P.Y. Patel, Cyclic AMP-associated shape change in mesangial cells and its reversal by prostaglandin E2, Kidnev Int. 25:874–879 (1984).

    Article  CAS  Google Scholar 

  58. J.B. Foidart and P. Mahieu, Glomerular mesangial cell contractility in vitro is controlled by an angiotensin-prostaglandin balance, Mol. Cell Endocrinol. 47:163–173 (1986).

    Article  CAS  Google Scholar 

  59. L.A. Scharschmidt, M. Simonson, M.J. Dunn, Glomerular prostaglandins, angiotensin II, and nonsteroidal anti-inflammatory drugs, Am. J. Med. 81 (suppl.2B):30–42 (1986).

    Article  CAS  PubMed  Google Scholar 

  60. R.P. Kimberly, R.E. Boden, H.R. Keiser, P.H. Plotz, Reduction of renal function by newer nonsteroidal anti-inflammatory drugs, Am. J. Med. 64:804–807 (1978).

    Article  CAS  PubMed  Google Scholar 

  61. M.J. Dunn, Nonsteroidal antiinflammatory drugs and renal function. Ann. Rev. Med. 35:411–428 (1984).

    Article  CAS  PubMed  Google Scholar 

  62. G. Ciabattoni, G.A. Cinotti, A. Pierucci, B.M. Simonetti, M. Manzi, F. Pugliese, P. Barsotti, G. Pecci, F. Taggi, C. Patrono, Effects of sulindac and ibuprofen in patients with chronic glomerular disease. Evidence for the dependence of renal function on prostacyclin, N. Eng. J. Med. 310:279–283 (1984).

    Article  CAS  Google Scholar 

  63. C. Patrono and M.J. Dunn, The clinical significance of inhibition of renal prostaglandin synthesis, Kidney Int. 32:1–12 (1987).

    Article  CAS  PubMed  Google Scholar 

  64. R. Vriesendorp, A.J.M. Donker, D. de Zeeuw, P.E. de Jong, G.K. van der Hem, J.R.H. Brentjens, Effects of nonsteroidal anti-inflammatory drugs on proteinuria, Am. J. Med. 81 (suppl. 2B) : 84–94 (1986).

    Article  CAS  PubMed  Google Scholar 

  65. B.M. Brenner, Nephron adaptation to renal injury or ablation, Am. J. Phvsiol. 249 (Renal Fluid Electrolyte Physiol.19):F324–F337 (1985).

    CAS  Google Scholar 

  66. L.D. Brace, D.L. Venton, G.C. Le Breton, Thromboxane A2/prostaglandin H2 mobilizes calcium in human blood platelets, Am. J. Phvsiol. 249 (Heart Circ. Physiol.18):H1–H7 (1985).

    CAS  Google Scholar 

  67. K. Fukuo, S. Morimoto, E. Koh, S. Yukawa, H. Tsuchiya, S. Imanaka, H. Yamamoto, T. Onoshi, Y. Kumahara, Effects of prostaglandins on the cytosolic free calcium concentration in vascular smooth muscle cells, Biochem. Biophvs. Res. Comm. 136:247–252 (1986).

    Article  CAS  Google Scholar 

  68. G.R. Dubyak and M.B. De Young, Intracellular Ca++ mobilization activated by extracellular ATP in Ehrlich ascites tumor cells, J. Biol. Chem. 260:10653–10661 (1985).

    CAS  PubMed  Google Scholar 

  69. G. Grynkiewicz, M. Poenie, R.Y. Tsien, A new generation of Ca2+ indicators with greatly improved fluorescence properties, J. Biol. Chem. 260:3440–3450 (1985).

    CAS  PubMed  Google Scholar 

  70. P. Mene’, G.R. Dubyak, A. Scarpa, M.J. Dunn, Stimulation of cytosolic free calcium and inositol phosphates by prostaglandins in cultured rat mesangial cells, Biochem. Biophys. Res. Comm. 142:579–586 (1987).

    Article  Google Scholar 

  71. J.B. Smith, Angiotensin-receptor signaling in cultured vascular smooth muscle cells, Am. J. Physiol. 250 (Renal Fluid Electrolyte Physiol. 19):F759–F769 (1986).

    CAS  PubMed  Google Scholar 

  72. A.V. Somlyo, M. Bond, A.P. Somlyo, A. Scarpa, Inositol trisphosphate-induced calcium release and contraction in vascular smooth muscle, Proc. Natl. Acad. Sci. USA 82:5231–5235 (1985).

    Article  CAS  PubMed  Google Scholar 

  73. J.V. Bonventre, K.L. Skorecki, J.I. Kreisberg, J.Y. Cheung, Vasopressin increases cytosolic free calcium concentration in glomerular mesangial cells, Am. J. Physiol. 251 (Renal Fluid Electrolyte Physiol. 20):F94–F102 (1986).

    CAS  PubMed  Google Scholar 

  74. A. Hassid, N. Pidikiti, D. Gamero, Effects of vasoactive peptides on cytosolic calcium in cultured mesangial cells, Am. J. Physiol. 251 (Renal Fluid Electrolyte Physiol. 20):F1018–F1028 (1986).

    CAS  PubMed  Google Scholar 

  75. M. Deleers, P. Grognet, R. Brasseur, Structural considerations for calcium ionophoresis by prostaglandins, Biochem. Pharmacol. 34: 3831–3836 (1985).

    Article  CAS  PubMed  Google Scholar 

  76. M.J. Berridge and R.F. Irvine, Inositol trisphosphate, a novel second messenger in cellular signal transduction, Nature (London) 312: 315–321 (1984).

    Article  CAS  Google Scholar 

  77. J.R. Williamson, Role of inositol lipid breakdown in the generation of intracellular signals, Hypertension 8 [Suppl. II]:II-140–II-156 (1986).

    CAS  Google Scholar 

  78. S. Muallem, M. Schoeffield, S. Pando1, G. Sachs, Inositol trisphosphate modification of ion transport in rough endoplasmic reticulum, Proc. Natl. Acad. Sci. USA 82:4433–4437 (1985).

    Article  CAS  PubMed  Google Scholar 

  79. B.C. Berk, T.A. Brock, M.A. Gimbrone, R.W. Alexander, Early agonist-mediated ionic events in cultured vascular smooth muscle cells, J. Biol. Chem. 262:5065–5072 (1987).

    CAS  PubMed  Google Scholar 

  80. P.T. Hawkins, L. Stephens, C.P. Downes, Rapid formation of inositol 1, 3, 4, 5-tetrakisphosphate and inositol 1,3,4-trisphosphate in rat parotid glands may both result indirectly from receptor-stimulated release of inositol 1, 4, 5-trisphosphate from phosphatidylinositol 4, 5-bisphosphate, Biochem. J. 238:507–516 (1986).

    CAS  PubMed  Google Scholar 

  81. R.F. Irvine and R.M. Moor, Micro-injection of inositol 1, 3, 4, 5-tetrakisphosphate activates sea urchin eggs by a mechanism dependent on external Ca2+, Biochem. J. 240:917–920 (1986).

    CAS  PubMed  Google Scholar 

  82. R.S. Adelstein and E. Eisenberg, Regulation and kinetics of the actinmyosin-ATP interaction, Ann. Rev. Biochem. 49:921–956 (1980).

    Article  CAS  PubMed  Google Scholar 

  83. E.D. Korn, Actin polymerization and its regulation by proteins from nonmuscle cells, Phvsiol. Rev. 62:672–737 (1982).

    CAS  Google Scholar 

  84. Y. Nishizuka, Studies and perspectives of protein kinase C, Science 233:305–312 (1986).

    Article  CAS  PubMed  Google Scholar 

  85. T. Hunter and J.A. Cooper, Protein-tyrosine kinases, Ann. Rev. Biochem. 54:897–930 (1985).

    Article  CAS  PubMed  Google Scholar 

  86. D.A. Troyer, O.F. Gonzalez, J.G. Douglas, J.I. Kreisberg, Phorbol ester inhibits arginine vasopressin activation of phospholipase C and promotes contraction of and prostaglandin production by cultured mesangial cells, Biochem. J. (in press) (1988).

    Google Scholar 

  87. J.I. Kreisberg, M.A. Venkatachalam, R.A. Radnik, P.Y. Patel, Role of myosin light-chain phosphorylation and microtubules in stress fiber morphology in cultured mesangial cells, Am. J. Phvsiol. 249 (Renal Fluid Electrolyte Physiol. 18) :F227–F235 (1985).

    CAS  Google Scholar 

  88. R.R. Gorman, S. Bunting, O.V. Miller, Modulation of human platelet adenylate cyclase by prostacyclin (PGX), Prostaglandins 13:377–388 (1977).

    CAS  PubMed  Google Scholar 

  89. N.K. Hopkins and R.R. Gorman, Regulation of endothelial cell cyclic nucleotide metabolism by prostacyclin, J. Clin. Invest. 67:540–546 (1981).

    Article  CAS  PubMed  Google Scholar 

  90. D. Oliva, A. Noe’, S. Nicosia, F. Bernini, R. Fumagalli, B.J.R. Whittle, S. Moneada, J.k. Vane, Prostacyclin-sensitive adenylate cyclase in cultured myocytes: differences between rabbit aorta and mesenteric artery, Eur. J. Pharmacol. 105:207–213 (1984).

    Article  CAS  PubMed  Google Scholar 

  91. E.G. Krebs and J.A. Beavo, Phosphorylation-dephosphorylation of enzymes, Ann. Rev. Biochem. 48:923–959 (1979).

    Article  CAS  PubMed  Google Scholar 

  92. R. Barnett, P.C. Singhal, L.A. Scharschmidt, D. Schlondorff, Dopamine attenuates the contractile response to angiotensin II in isolated rat glomeruli and cultured mesangial cells, Cir. Res. 59:529–533 (1986).

    Article  CAS  Google Scholar 

  93. J.N. Fain, R.H. Pointer, W.F. Ward, Effects of adenosine nucleotides on adenylate cyclase, phosphodiesterase, cyclic adenosine monophosphate accumulation and lipolysis in fat cells, J. Biol. Chem. 247: 6866–6872 (1972).

    CAS  PubMed  Google Scholar 

  94. R.J. Haslam, M.M.L. Davidson, J.V. Desjardin, Inhibition of adenylate cyclase by adenosine analogues in preparations of broken and intact platelets, Biochem. J. 176:83–95 (1978).

    CAS  PubMed  Google Scholar 

  95. R.A. Coleman and I. Kennedy, Characterization of the prostanoid receptors mediating contraction of guinea-pig isolated trachea, Prostaglandins 29:363–375 (1985).

    CAS  PubMed  Google Scholar 

  96. J.E. Stork and M.J. Dunn, Hemodynamic roles of thromboxane A2 and prostaglandin E2 in glomerulonephritis, J. Pharm. Exp. Ther. 233:672–678 (1985).

    CAS  Google Scholar 

  97. M.A. Rahman, S.N. Emancipator, M.J. Dunn, Immune complex effects on glomerular eicosanoid production and renal hemodynamics, Kidney Int. 31:1317–1326 (1987).

    Article  CAS  PubMed  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Departments of Medicine and Physiology, Case Western Reserve University School of Medicine, Cleveland, Ohio, 44106, USA

    Paolo Mené, Michael S. Simonson & Michael J. Dunn

  2. Division of Nephrology, University Hospitals of Cleveland, Ohio, 44106, USA

    Paolo Mené, Michael S. Simonson & Michael J. Dunn

Authors
  1. Paolo Mené
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Michael S. Simonson
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Michael J. Dunn
    View author publications

    You can also search for this author in PubMed Google Scholar

Editor information

Editors and Affiliations

  1. Case Western Reserve University, Cleveland, Ohio, USA

    Michael J. Dunn

  2. University Hospitals of Cleveland, Cleveland, Ohio, USA

    Michael J. Dunn

  3. Catholic University School of Medicine, Rome, Italy

    Carlo Patrono

  4. University of Rome “La Sapienza”, Rome, Italy

    Giulio A. Cinotti

Rights and permissions

Reprints and permissions

Copyright information

© 1989 Plenum Press, New York

About this chapter

Cite this chapter

Mené, P., Simonson, M.S., Dunn, M.J. (1989). Prostaglandins, Thromboxane and Leukotrienes in the Control of Mesangial Function. In: Dunn, M.J., Patrono, C., Cinotti, G.A. (eds) Renal Eicosanoids. Advances in Experimental Medicine and Biology, vol 259. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-5700-1_8

Download citation

  • DOI: https://doi.org/10.1007/978-1-4684-5700-1_8

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4684-5702-5

  • Online ISBN: 978-1-4684-5700-1

  • eBook Packages: Springer Book Archive

Publish with us

Policies and ethics

Search

Navigation