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Peptide Hormones, Cytosolic Calcium and Renal Epithelial Response

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Renal Eicosanoids

Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 259))

Abstract

The response of renal cells to extracellular signals has recently attracted increasing experimental evaluation. The cellular response to a variety of peptide hormones, neurotransmitters and growth factors are fundamental to understanding how the signals mediated by circulatory substances, which interact with cell surface receptors, produce their effects intracellularly. The cellular responses to a wide variety of signal molecules are somewhat limited. Occupancy of receptors initiates the production of intracellular messengers including cAMP, cGMP and the second messenger molecules derived from phosphoinositides (1–3). The phosphoinositides constitute 5–8% of lipids in the cell membranes of eukaryotic cells and are essential for cell viability (4). These phosphoinositides are storage forms for the messenger molecules that transmit signals across the cell membrane and evoke responses to extracellular signals.

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Authors and Affiliations

  1. Departments of Medicine and Pharmacology, Washington University School of Medicine, St. Louis, Missouri, 63110, USA

    Aubrey R. Morrison, Didier Portilla & Daniel Coyne

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Editors and Affiliations

  1. Case Western Reserve University, Cleveland, Ohio, USA

    Michael J. Dunn

  2. University Hospitals of Cleveland, Cleveland, Ohio, USA

    Michael J. Dunn

  3. Catholic University School of Medicine, Rome, Italy

    Carlo Patrono

  4. University of Rome “La Sapienza”, Rome, Italy

    Giulio A. Cinotti

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Morrison, A.R., Portilla, D., Coyne, D. (1989). Peptide Hormones, Cytosolic Calcium and Renal Epithelial Response. In: Dunn, M.J., Patrono, C., Cinotti, G.A. (eds) Renal Eicosanoids. Advances in Experimental Medicine and Biology, vol 259. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-5700-1_7

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