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Lipoxygenase Products and Their Functions in Glomeruli

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Renal Eicosanoids

Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 259))

Abstract

Non-esterified arachidonic acid (C20:4) may be oxygenated by three major lipoxygenase pathways. These include the 5-, 12-, and 15-lipoxygenases which stereospecifically insert one oxygen molecule at the 5, 12, and 15 positions of this fatty acid via mechanisms involving hydrogen abstraction. Each of these enzymes converts C20:4 into a number of metabolites which, for many of them, represent essential mediators of inflammation. C20:4 is also the substrate for cyclooxygenase. Glomerular synthesis of the cyclooxygen-ase metabolites, prostaglandins (PG) and thromboxane (TX) and the role of these products on glomerular hemodynamics and the inflammatory injury during glomerular diseases have been extensively studied (1–3). This review will discuss the metabolism of C20:4 to its lipoxygenase products in glomeruli and their effects on glomerular functions. Potential pathophysiological action of these metabolites in glomerular inflammation will also be considered.

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Authors and Affiliations

  1. INSERM 64, Hôpital Tenon, Paris, France

    Raymond Ardaillou, Laurent Baud & Josée Sraer

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  1. Raymond Ardaillou
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  2. Laurent Baud
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  3. Josée Sraer
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Editors and Affiliations

  1. Case Western Reserve University, Cleveland, Ohio, USA

    Michael J. Dunn

  2. University Hospitals of Cleveland, Cleveland, Ohio, USA

    Michael J. Dunn

  3. Catholic University School of Medicine, Rome, Italy

    Carlo Patrono

  4. University of Rome “La Sapienza”, Rome, Italy

    Giulio A. Cinotti

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© 1989 Plenum Press, New York

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Ardaillou, R., Baud, L., Sraer, J. (1989). Lipoxygenase Products and Their Functions in Glomeruli. In: Dunn, M.J., Patrono, C., Cinotti, G.A. (eds) Renal Eicosanoids. Advances in Experimental Medicine and Biology, vol 259. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-5700-1_3

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  • DOI: https://doi.org/10.1007/978-1-4684-5700-1_3

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4684-5702-5

  • Online ISBN: 978-1-4684-5700-1

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