Abstract
The concept that cell-cell interaction might modify the metabolism of arachidonic acid (AA) was already suggested nearly ten years ago by several studies in which platelets and blood vessels were coincubated and AA metabolites were analysed. Over subsequent years most of the researchers in this field focused their interest on the interaction between either endothelium and platelets, polymorphonuclear leukocytes (PMNL) and platelets, or PMNL and endothelium. A brief review of these interactions occurring in nonrenal tissue will be presented. The hypothesis that the glomerulus, which includes a peculiar endothelium, could be a preferential site for cell-cell interaction has not been investigated until recently. Yet, it is well documented that activated bone marrow-derived cells may invade the glomerular capillary in a number of experimental or human glomerulonephritides. Both cell types—glomerular and bone marrow-derived cells—were recognized to be the source of various lipidic inflammatory agents such as platelet-activating factor (PAF), prostaglandins (PG), hydroxyeicosatetraenoic acids (HETE) and leukotrienes (LT). This review focuses upon recent results providing strong evidence that, during interaction between glomerular and bone marrow-derived cells, changes occur in arachidonate metabolism. The functional consequence of these changes will be discussed, but we shall limit this review to the interactions involving lipidic factors.
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Sraer, J., Bens, M., Oudinet, JP., Baud, L. (1989). Arachidonic Acid Metabolism During Interactions Between Glomerular and Bone Marrow-Derived Cells. In: Dunn, M.J., Patrono, C., Cinotti, G.A. (eds) Renal Eicosanoids. Advances in Experimental Medicine and Biology, vol 259. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-5700-1_2
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