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Renal Eicosanoids pp 249–274Cite as

Eicosanoids: Role in Experimental Renal Disease

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Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 259))

Abstract

Endogenous prostaglandin biosynthesis modulates such renal functions as regional blood flow (1), salt and water transport (2), renin secretion (3,4) and neurotransmitter release (5). More recently, the vasoconstrictor thromboxane A2, which normally is quantitatively a minor product of arachidonic acid metabolism in the kidney under resting or basal conditions, has been shown to be increased in several models of renal injury and may be, in part, responsible for some of the pathophysiological derangements (6–9). Two models, ureteral obstruction and subtotal renal ablation, in which thromboxane seems to play a pathogenetic role, are described in more detail in this chapter. In addition, the role of prostaglandins, thromboxane and dietary fatty acids on kidney function and structure in several immunological models of renal disease and hypertension are discussed.

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Authors and Affiliations

  1. Renal Division, Department of Medicine, Washington University School of Medicine, St. Louis, Missouri, 63110, USA

    Saulo Klahr & Mabel L. Purkerson

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  1. Saulo Klahr
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Editors and Affiliations

  1. Case Western Reserve University, Cleveland, Ohio, USA

    Michael J. Dunn

  2. University Hospitals of Cleveland, Cleveland, Ohio, USA

    Michael J. Dunn

  3. Catholic University School of Medicine, Rome, Italy

    Carlo Patrono

  4. University of Rome “La Sapienza”, Rome, Italy

    Giulio A. Cinotti

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Klahr, S., Purkerson, M.L. (1989). Eicosanoids: Role in Experimental Renal Disease. In: Dunn, M.J., Patrono, C., Cinotti, G.A. (eds) Renal Eicosanoids. Advances in Experimental Medicine and Biology, vol 259. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-5700-1_11

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