Abstract
The recurring process of ovarian follicular growth is an exponential rather than a linear process characterized by substantial dramatic proliferation and differentiation of the granulosa cell. Although the pivotal role(s) of gonadotropins and of gonadal steroids in this explosive agenda is well recognized, the variable fate of follicles subject to comparable gonadotropic support suggests the existence of additional intraovarian regulatory mechanism(s). Among potential novel intraovarian regulators, insulin-like growth factor I (IGF-I) has been receiving increasingly intense scrutiny (1–2). Taken together these studies strongly suggest the existence of an intraovarian autocrine control mechanism, wherein IGF-I may serve as the central signal, and the granulosa cell its site of production, reception, and action. Viewed in this light, IGF-I may promote the growth and/or differentiation of the granulosa cell, acting for the most part as an amplifier of gonadotropin action. Granulosa cell-derived IGF-I may also provide paracrine input to the nearby theca-interstitial cell compartment in the interest of coordinated follicular function.
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References
Hammond JM. Peptide regulators in the ovarian follicle. Aust J Biol Sci 1981; 34:491.
Adashi EY, Resnick CE, D’Ercole AJ, Svoboda ME, Van Wyk JJ. Insulin-like growth factors as intraovarian regulators of granulosa cell growth and function. Endocr Rev 1985; 6:400.
Murphy LJ, Bell GI, Friesen HG. Tissue distribution of insulin-like growth factor I and II messenger ribonucleic acid in the adult rat. Endocrinology 1987; 120:1279.
Davoren JB, Hsueh AJW. Growth hormone increases ovarian levels of immunoreactive somatomedin-C/insulin-like growth factor I in vivo. Endocrinology 1986; 118:888.
Hernandez ER, Hoyt E, Van Wyk JJ, Adashi EY. The somatomedin-C/insulin-like growth factor I (Sm-C/IGF-I) gene is expressed in the rat ovary. [Abstract]. Abstract 821, 69th Annual Meeting of the Endocrine Society, Indianapolis, IN, 1987.
Adashi EY, Resnick CE, Hernandez ER, Svoboda ME, Van Wyk JJ. Characterization and regulation of a specific cell membrane receptor for somatomedin-C/insulin-like growth factor I in cultured rat granulosa cells. Endocrinology 1988; 122:194–201.
Adashi EY, Resnick CE, Svoboda ME, Van Wyk JJ. Follicle-stimulating hormone enhances somatomedin-C binding to cultured rat granulosa cells: evidence for cAMP dependence. J Biol Chem 1986; 261:3923.
Adashi EY, Resnick CE, Svoboda ME, Van Wyk JJ. In vivo regulation of granulosa cell somatomedin-C/insulin-like growth factor I receptors. Endocrinology 1988; 122:383–1390.
Davoren JB, Kasson BG, Li CH, Hsueh AJW. Specific insulin-like growth factor (IGF) I- and II-binding sites on rat granulosa cells: relations to IGF action. Endocrinology 1986; 119:2155.
Davoren JB, Hsueh AJW, Li CH. Somatomedin C augments FSH-induced differentiation of cultured rat granulosa cells. Am J Physiol 1985; 249:E26.
Bicsak TA, Tucker EM, Cappel S, et al. Hormonal regulation of granulosa cell inhibin biosynthesis. Endocrinology 1986; 119:2711.
Zhiwen Z, Carson RS, Herington AC, Lee VWK, Burger HG. Follicle-stimulating hormone and somatomedin-C stimulate inhibin production by rat granulosa cells in vitro. Endocrinology 1987; 120:1633.
Adashi EY, Resnick CE, Svoboda ME, Van Wyk JJ. Somatomedin-C as an amplifier of follicle-stimulating hormone action: enhanced accumulation of adenosine 3′,5′-monophosphate. Endocrinology 1986; 118:149.
May JV, Schomberg DW, Grodon S, Amsterdam A. Synergistic effect of insulin and follicle-stimulating hormone on biochemical and morphological differentiation of porcine granulosa cells. Bio Reprod 1985; 32(suppl):53.
Busby WH, Klapper DL, Clemmons DR. Purification of a 34,000 dalton somatomedin-C binding protein from human amniotic fluid. Isolation of two forms with different biologic actions. J Biol Chem 1987.
Clemmons DR, Elgin RG, Han VKM, Casella SJ, D’Ercole AJ, Van Wyk JJ. Cultured fibroblast monolayers secrete a protein that alters the cellular binding of somatomedin-C/insulin-like growth factor I. J Clin Invest 1986; 77:1548.
DeVroede MA, Tseng L-YH, Katsoyannis PG, Nissley SP, Rechler MM. Modulation of insulin-like growth factor I binding to human fibroblast monolayer cultured by insulin-like growth factor carrier proteins released to the incubation media. J Clin Invest 1986; 77:602.
Elgin RG, Busby WH, Clemmons DR. An insulin-like growth factor (IGF) binding protein enhances the biologic response to IGF-L Proc Natl Acad Sci USA 1987; 84:3254.
Koistinen R, Kalkkinen N, Huhtala M-L, Seppala M, Bonn H, Butanen EM. Placental protein 12 is a decidual protein that binds somatomedin and has an identical N-terminal amino acid sequence with somatomedin-binding protein from human amniotic fluid. Endocrinology 1986; 118:1375.
Seppala M, Koskimies AI, Tenhunen A, et al. Pregnancy proteins in seminal plasma, seminal vesicles, preovulatory follicular fluid and ovary. Ann NY Acad Sci 212.
Hernandez ER, Resnick CE, Svoboda ME, Van Wyk JJ, Payne DW, Adashi EY. Somatomedin-C/insulin-like growth factor I as an enhancer of androgen biosynthesis by cultured rat ovarian cells. Endocrinology 1988; 122:1603–13.
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© 1989 Plenum Press, New York
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Adashi, E.Y. et al. (1989). Rodent Studies on the Potential Relevance of Insulin-Like Growth Factor (IGF-I) to Ovarian Physiology. In: Hirshfield, A.N. (eds) Growth Factors and the Ovary. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-5688-2_7
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DOI: https://doi.org/10.1007/978-1-4684-5688-2_7
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