Abstract
During follicular development, granulosa cells produce glycosaminoglycans (GAGs) as constituents which are secreted into follicular fluid (1). GAGs stimulate appearance of gonadotropin receptors on granulosa cells cultured in vitro (2). Conversely, follicular GAGs inhibit gonadotropin binding to cell surface receptors (2,3). They inhibit progesterone secretion (4,5) and may inhibit steroidogenesis indirectly by altering the binding and degradation of lipoproteins (4).
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© 1989 Plenum Press, New York
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Winer, M.A., Ax, R.L. (1989). Heparin-Binding Proteins in Purified Plasma Membranes of Bovine Granulosa Cells. In: Hirshfield, A.N. (eds) Growth Factors and the Ovary. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-5688-2_37
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DOI: https://doi.org/10.1007/978-1-4684-5688-2_37
Publisher Name: Springer, Boston, MA
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