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Mechanisms by Which Vasoactive Intestinal Peptide Regulate Baboon Granulosa Cell Steroidogenesis

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Growth Factors and the Ovary

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Abstract

Vasoactive intestinal peptide (VIP) has been shown to enhance steroid production in vivo in rabbits (1) and humans (2) and in vitro in prepubertal rat ovaries (3), isolated rat granulosa cells (4), as well as cultured baboon granulosa cells (5). In addition, Gozes and Tsafriri (6) have found VIP-encoding mRNA in rat ovaries, suggesting a local ovarian synthesis of VIP.

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References

  1. Fredericks CM, Lundquist LE, Mathur RS, Ashton SH, Landgrebe SC. Effects of vasoactive intestinal polypeptide upon ovarian steroid, ovum transport, and fertility in the rabbit. Biol Reprod 1983; 28:1052–60.

    Article  PubMed  CAS  Google Scholar 

  2. Otteson B, Pedersen B, Nielsen J, Dalgaard D, Fahrenkrug J. Effect of vasoactive intestine polypeptide (VIP) on steroidogenesis in women. Regul Pept 1986; 16:299–304.

    Article  Google Scholar 

  3. Ahmed CE, Dees WL, Ojeda SR. The immature rat ovary is innervated by vasoactive intestinal peptide (VlP)-containing fibers and responds to VIP with steroid secretion. Endocrinology 1986; 118:1680–9.

    Article  Google Scholar 

  4. Davoren BJ, Hsueh AJW. Vasoactive intestinal peptide: a novel stimulator of steroidogenesis by cultured rat granulosa cells. Biol Reprod 1985; 33:37–52.

    Article  PubMed  CAS  Google Scholar 

  5. Silavin SL. Role of vasoactive intestinal peptide (VIP) in steroidogenesis by cultured baboon granulosa cells. Biol Reprod 1987; 36(suppl 1):49.

    Google Scholar 

  6. Gozes I, Tsafriri A. Detection of vasoactive intestinal peptide-encoding messenger ribonucleic acid in the rat ovaries. Endocrinology 1986; 2606–10.

    Google Scholar 

  7. Kowal J, Horst I, Pensky J, Alfonzo M. A comparison of the effects of ACTH, vasoactive intestinal peptide and cholera toxin on adrenal cAMP and steroid synthesis. Ann NY Acad Sci 1977; 297:314–28.

    Article  PubMed  CAS  Google Scholar 

  8. Kasson BG, Lim P, Hsueh AJW. Vasoactive intestinal peptide stimulates androgen biosynthesis by cultured neonatal testicular cells. Mol Cell Endocrinol 1986; 48:21–9.

    Article  PubMed  CAS  Google Scholar 

  9. Toccafondi RS, Brandi ML, Melander A. Vasoactive intestinal peptide stimulation of human thyroid cell function. J Clin Endocrinol Metab 1984; 58:157–60.

    Article  PubMed  CAS  Google Scholar 

  10. Davoren JG, Hsueh AJW. Insulin enhances FSH-stimulated steroidogenesis by cultured rat granulosa cells. Mol Cell Endocrinol 1984; 35:97–105.

    Article  PubMed  CAS  Google Scholar 

  11. May JV, Schomberg DW. Granulosa cell differentiation in vitro: effect of insulin on growth and functional integrity. Biol Reprod 1981; 25:421–31.

    Article  PubMed  CAS  Google Scholar 

  12. Veldhuis JD, Kolp LA, Toaff ME, Strauss JF III, Demers LM. Mechanisms subserving the tropic actions of insulin on ovarian cells: in vitro studies using swine granulosa cells. J Clin Invest 1983; 72:1046–57.

    Article  PubMed  CAS  Google Scholar 

  13. Bradford MM. A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding. Anal Biochem 1976; 72:248–54.

    Article  PubMed  CAS  Google Scholar 

  14. Kubasik NP, Halluer GD, Bradows RG. Evaluation of a direct solid-phase radioimmunoassay for progesterone, useful for monitoring luteal function. Clin Chem 1984; 30:284–6.

    PubMed  CAS  Google Scholar 

  15. Silavin SL, Strauss JF III. Progesterone production by hamster granulosa and luteal cells during short-term incubation. Effects of lipoproteins, compactin and 25-hydroxycholesterol. Biol Reprod 1983; 29:1163–71.

    Article  PubMed  CAS  Google Scholar 

  16. Said SI, Mutt V. Polypeptide with broad biological activity: isolation from small intestine. Science 1970; 169:1217–8.

    Article  PubMed  CAS  Google Scholar 

  17. Larsson LI, Fahrenkrug J, Schaffalitzky de Muckadell OB. Vasoactive intestinal peptide occurs in nerves of the female genitourinary tract. Science 1977; 197:1374–5.

    Article  PubMed  CAS  Google Scholar 

  18. Alm P, Alumets J, Hakanson R, et al. Origin and distribution of VIP (vasoactive intestinal peptide)-nerves in the genito-urinary tract. Cell Tissue Res 1980; 205:337–47.

    Article  PubMed  CAS  Google Scholar 

  19. Alm P, Alumets J, Hakanson R, Owman C, Sjoberg N-O, Sundler F. Vasoactive intestinal polypeptide nerves in the human female genital tract. Am J Obstet Gynecol 1980; 136:349–51.

    PubMed  CAS  Google Scholar 

  20. Trzeciak WH, Ahmed CE, Simpson ER, Ojeda SR. Vasoactive intestinal peptide induces the synthesis of the cholesterol side-chain cleavage complex in cultured rat ovarian granulosa cells. Proc Natl Acad Sci USA 1986; 83:7490–4.

    Article  PubMed  CAS  Google Scholar 

  21. Trezeciak WH, Waterman MR, Simpson ER, Ojeda SR. Vasoactive intestinal peptide regulates cholesterol side-chain cleavage cytochrome P-450 (P450scc) gene expression in granulosa cells from immature rat ovaries. Molec Endocrinol 1987; 1:500–4.

    Article  Google Scholar 

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Authors and Affiliations

  1. Department of Obstetrics and Gynecology, Health Sciences Center, University of Oklahoma, P.O. Box 26901, Oklahoma City, OK, 73190, USA

    Susan L. Silavin

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  1. Susan L. Silavin
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Editors and Affiliations

  1. University of Maryland, Baltimore, Maryland, USA

    Anne N. Hirshfield

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© 1989 Plenum Press, New York

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Silavin, S.L. (1989). Mechanisms by Which Vasoactive Intestinal Peptide Regulate Baboon Granulosa Cell Steroidogenesis. In: Hirshfield, A.N. (eds) Growth Factors and the Ovary. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-5688-2_36

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  • DOI: https://doi.org/10.1007/978-1-4684-5688-2_36

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4684-5690-5

  • Online ISBN: 978-1-4684-5688-2

  • eBook Packages: Springer Book Archive

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