Abstract
The ovarian surface epithelium is a modified mesothelial tissue which undergoes species-dependent morphogenetic events throughout life (1,2). The mechanisms regulating such events are poorly understood in spite of the relevance of this tissue in reproduction and cancer (3,4). We have postulated that ovarian mesothelial cells may be influenced by underlying growth signals based on the observation of highly polarized DNA synthesis and morphogenesis in the postovulatory rabbit ovary (5). In the present study, we report on the isolation, biological activity and initial characterization of a recently discovered intraluteal growth factor for rabbit ovarian mesothelial cells (6).
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
Preview
Unable to display preview. Download preview PDF.
References
Motta PM, Van Blerkom J, Makabe S. Changes in the surface morphology of ovarian germinal epithelium during the reproductive cycle and in some pathological conditions. J Submicrosc Cytol 1980; 12:407–15.
Nicosia SV. Morphological changes of the human ovary throughout life. In: Serra GB, ed. The ovary. New York: Raven Press, 1983:57–81.
Bjersing L, Cajander S. Ovulation and the mechanism of follicle rupture. III. Transmission electron microscopy of rabbit germinal epithelium prior to induced ovulation. Cell Tissue Res 1974; 149:313–27.
Nicosia SV, Nicosia RF. Neoplasms of the ovarian mesothelium. In: Azar HA, ed. Pathology of human neoplasms. New York: Raven Press, 1988:435–86.
Osterholzer HO, Johnson JH, Nicosia SV. An autoradiographic study of the rabbit ovarian surface epithelium before and after ovulation. Biol Reprod 1985; 33:729–38.
Nicosia SV, Saunders BO. Corpus luteum extract stimulates the growth of ovarian surface epithelial cells. Lab Invest 1986; 54:47a.
Bradford MN. A rapid and sensitive method forthe quantitation of microgram quantities of proteins utilizing a principle of protein-dye binding. Ann Biochem 1976; 72:238–54.
Nicosia SV, Johnson JH, Streibel EJ. Isolation and ultrastructure of rabbit ovarian mesothelium (surface epithelium). Int J Gynecol Pathol 1984; 3:338–60.
Nicosia SV, Johnson JH, Streibel EJ. Growth characteristics of rabbit ovarian mesothelial (surface epithelial) cells. Int J Gynecol Pathol 1985; 4:58–74.
Goustin AS, Leof EB, Shipley GD, Moses HL. Growth factors and cancer. Cancer Res 1986;46:1015–29.
Nicosia SV, Johnson JH. Surface morphology of ovarian mesothelium (surface epithelium) and of other pelvic and extrapelvic mesothelial sites in the rabbit. Int J Gynecol Pathol 1984; 3:249–60.
Mukku VR, Stancel GM. Regulation of epidermal growth factor receptor by estrogen. J Biol Chem 1985; 260:9820–4.
Osterholzer HO, Streibel EJ, Nicosia SV. Growth effects of protein hormones on cultured rabbit ovarian surface epithelial cells. Biol Reprod 1985; 33:247–58.
Gospodarowicz D, Cheng J, Lui GM, Baird A, Esch F, Bohlen P. Corpus luteum angiogenic factor is related to fibroblast growth factor. Endocrinology 1985; 117:2283–391.
Lobb DK, Kobrin MC, Kudlow JE, Dorrington JH. Transforming growth factor-alpha production by bovine thecal cells. Biol Reprod 1988; 38(1): 191a.
Mondschein JS, Hammond JM, Canning SF. Profiles of immunoreactive insulin-like growth factors I and II in porcine follicular fluid and granulosa cell conditioned medium. BiolReprod 1988; 38(l):191a.
Author information
Authors and Affiliations
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 1989 Plenum Press, New York
About this chapter
Cite this chapter
Nicosia, S.V., Saunders, B.O. (1989). Initial Characterization of a Luteal Growth Factor for Ovarian Mesothelial Cells. In: Hirshfield, A.N. (eds) Growth Factors and the Ovary. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-5688-2_26
Download citation
DOI: https://doi.org/10.1007/978-1-4684-5688-2_26
Publisher Name: Springer, Boston, MA
Print ISBN: 978-1-4684-5690-5
Online ISBN: 978-1-4684-5688-2
eBook Packages: Springer Book Archive