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Growth Factors and the Ovary pp 131–139Cite as

Growth Factor-Gonadotropin Interactions in Ovarian Cells

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Abstract

The literature now contains several publications demonstrating that classical reproductive hormones and growth factors interact to modulate ovarian cellular function (see reviews 1–3). Examples on a general level are: (1) regulation by reproductive hormones of growth factor production; (2) modulation of growth factor receptor expression/function by reproductive hormones; or conversely, (3) modulation of the production of reproductive hormones by growth factors; and, (4) growth factor involvement in regulating the expression/function of receptors for reproductive hormones. However, detailed biochemical knowledge in terms of the intracellular mechanisms by which these various effectors interact to regulate growth or differentiation is not yet available for any cell type. Also, at this level, there is no information to indicate whether growth factor-initiated mechanisms are the same in reproductive hormone-responsive vs. nonresponsive cells.

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References

  1. Adashi EY, Resnick CE, D’Ercole AJ, Svoboda ME, Van Wyk JJ. Insulin-like growth factors as intraovarian regulators of granulosa cell growth and function. Endocr Rev 1985; 6:400.

    Article  PubMed  CAS  Google Scholar 

  2. Schomberg DW. Regulation of follicle development by gonadotropins and growth factors. In: Stouffer RL, ed. The Primate Ovary. New York: Plenum Press, 1987:25–33.

    Chapter  Google Scholar 

  3. Schomberg DW. The role of growth factors in the regulation of ovarian growth and function. In: Parvinen M, Huhtaniemi I, Pelliniem LJ, eds. Rome: Ares-Serono Symposia, 1988:127–38.

    Google Scholar 

  4. Mondschein JS, Schomberg DW. Growth factors modulate gonadotropin receptor induction in granulosa cell cultures. Science 1981; 211:1179–80.

    Article  PubMed  CAS  Google Scholar 

  5. Mondschein JS, Schomberg DW. Effects of partially and more highly purified platelet-derived growth factor preparations on luteinizing hormone receptor induction in granulosa cell cultures. Biol Reprod 1984; 30:603–8.

    Article  PubMed  CAS  Google Scholar 

  6. Heldin CH, Westermark B, Wasteson A. Platelet-derived growth factor: purification and partial characterization. PNAS (USA) 1979; 76:3722–6.

    Article  CAS  Google Scholar 

  7. Blair EI, Kim I-C, Estes JE, Keski-Oja J, Schomberg DW. Human PDGF preparations contain a separate activity which potentiates FSH-mediated induction of LH receptor in cultured rat granulosa cells: evidence for transforming growth factor beta. Endocrinology (in press).

    Google Scholar 

  8. Knecht M, Catt KJ. Modulation of cAMP-mediated differentiation in ovarian granulosa cells by epidermal growth factor and platelet-derived growth factor. J Biol Chem 1983; 258:2789–94.

    PubMed  CAS  Google Scholar 

  9. May JV, Frost JP, Schomberg DW. Differential effects of epidermal growth factor, somatomedin-C/insulin-like growth factor I, and transforming growth factor-β on porcine granulosa cell deoxyribonucleic acid synthesis and cell proliferation. Endocrinology 1988; 123:168–79.

    Article  PubMed  CAS  Google Scholar 

  10. Goustin AS, Betsholz C, Pfeifer-Ohlsson S, et al. Coexpression of the sis and myc protooncogenes in developing human placenta suggests autocrine control of trophoblastic growth. Cell 1985; 41:301.

    Article  PubMed  CAS  Google Scholar 

  11. Skinner MK, Keski-Oja J, Osteen KG, Moses HL. Ovarian thecal cells produce transforming growth factor-beta which can regulate granulosa cell growth. Endocrinology 1987; 121:786–92.

    Article  PubMed  CAS  Google Scholar 

  12. Hernandez ER, Twardzik DR, Purchio A, Adashi EY. Gonadotropin-dependent ovarian transforming growth factor-beta gene expression. Biol Reprod 1987; 36(suppl 1):58.

    Google Scholar 

  13. Ruegseggar Veit C, Assoian RK. Identification of transforming growth factor-beta in human ovarian follicular fluid [Abstract]. Abstract No. 1225, Proc 70th Ann Meeting of The Endocrine Society, New Orleans, 1988.

    Google Scholar 

  14. Miyazono K, Hellman U, Wemstedt C, Heldin C-H. Latent high molecular weight complex of transforming growth factor B1. J Biol Chem 1988; 263:6407–15.

    PubMed  CAS  Google Scholar 

  15. Wakefield LM, Smith DM, Flanders KC, Sporn MB. Latent transforming growth factor-β from human platelets. J Biol Chem 1988; 263:7646–54.

    PubMed  CAS  Google Scholar 

  16. Van Obberghen-Schilling E, Roche N, Flanders KC, Sporn MB, Roberts AB. Transforming growth factor Bl positively regulates its own expression in normal and transformed cells. J Biol Chem 1988; 263:7741–6.

    PubMed  Google Scholar 

  17. Knabbe C, Lippman ME, Wakefield LM, et al. Evidence that transforming growth factor-beta is a hormonally regulated negative growth factor in human breast cancer cells. Cell 1987; 48:417–28.

    Article  PubMed  CAS  Google Scholar 

  18. Ikeda T, Lioubin MN, Marquardt H. Human transforming growth factor type B2: production by a prostatic adenocarcinoma cell line, purification, and initial characterization. Biochemistry 1988; 26:2406–10.

    Article  Google Scholar 

  19. Lawrence DA, Pircher R, Jullien P. Conversion of a high molecular weight latent β-TGF from chicken embryo fibroblasts into a low molecular weight active β-TGF under acidic conditions. Biochem Biophys Res Commun 1985; 133:1026–34.

    Article  PubMed  CAS  Google Scholar 

  20. Sporn MB, Roberts AB, Wakefield LM, Assoian RK. Transforming growth factor-β: biological function and chemical structure. Science 1986; 233:532–4.

    Article  PubMed  CAS  Google Scholar 

  21. Dorrington JA, Chuma V, Bendell JJ. Transforming growth factor β and follicle-stimulating hormone promote rat granulosa cell proliferation. Endocrinology 1988; 123:353–9.

    Article  PubMed  CAS  Google Scholar 

  22. Knecht M, Feng P, Catt KJ. Transforming growth factor-beta regulates the expression of luteinizing hormone receptors in ovarian granulosa cells. Biochem Biophys Res Commun 1986; 139:800–7.

    Article  PubMed  CAS  Google Scholar 

  23. Dodson WC, Schomberg DW. The effect of transforming growth factor-β on follicle-stimulating hormone-induced differentiation of cultured rat granulosa cells. Endocrinology 1987; 120:512–6.

    Article  PubMed  CAS  Google Scholar 

  24. Adashi EY, Resnick CE. Antagonistic interactions of transforming growth factors in the regulation of granulosa cell differentiation. Endocrinology 1986; 119:1879–81.

    Article  PubMed  CAS  Google Scholar 

  25. Knecht M, Feng P, Catt KJ. Bifunctional role of transforming growth factor-β during granulosa cell development. Endocrinology 1987; 120:1243–9.

    Article  PubMed  CAS  Google Scholar 

  26. Cheifetz S, Weatherbee JA, Tsang M L-S, et al. The transforming growth factor-β system, a complex pattern of cross-reactive ligands and receptors. Cell 1987; 48:409–15.

    Article  PubMed  CAS  Google Scholar 

  27. Markovac J, Goldstein GW. Transforming growth factor beta activates protein kinase C in microvessels isolated from immature rat brain. Biochem Biophys Res Commun 1988; 150:575–82.

    Article  PubMed  CAS  Google Scholar 

  28. Libby J, Martinez R, Weber MJ. Tyrosine phosphorylation in cells treated with transforming growth factor-β. J Cell Physiol 1986; 129:159–66.

    Article  PubMed  CAS  Google Scholar 

  29. Kim I-C, May JV, Schomberg DW. The potential mechanism by which human transforming growth factor-β (hTGF-β) modulates FSH-induced differentiation of cultured rat granulosa cells (GC) [Abstract No. 237]. Biol Reprod 1987; 36(suppl 1):125.

    Article  Google Scholar 

  30. Gospodarowicz D, Ill CR, Birdwell CR. Effects of fibroblast and epidermal growth factors on ovarian cell proliferation in vitro. I. Characterization of the response of granulosa cells to FGF and EGF. Endocrinology 1977; 100:1108–20.

    Article  PubMed  CAS  Google Scholar 

  31. Gospodarowicz D, Mescher AL, Birdwell CR. Control of cellular proliferation by the fibroblast and epidermal growth factors. In: Third decennial review conference: cell, tissue, and organ culture. National Cancer Institute Monograph 48. Bethesda: USPHS, NIH 1978:109–30.

    Google Scholar 

  32. Shaw G, Jorgenson GI, Tweendale R, Tennison M, Waters MJ. Effect of epidermal growth factor on reproductive function of ewes. J Endocrinol 1985; 107:429–36.

    Article  PubMed  CAS  Google Scholar 

  33. Radford HM, Panaretto BA, Avenell JA, Turnbull KE. Effect of mouse epidermal growth factor on plasma concentrations of FSH, LH, and progesterone and on oestrus, ovulation and ovulation rate in merino ewes. J Reprod Fertil 1987; 80:383–8.

    Article  PubMed  CAS  Google Scholar 

  34. Rall LB, Scott J, Bell GI. Mouse preproepidermal growth factor synthesis by the kidney and other tissues. Nature 1985; 313:228–30.

    Article  PubMed  CAS  Google Scholar 

  35. Hsu C-J, Holmes SD, Hammond JM. Ovarian epidermal growth factor-like activity. Concentrations in porcine follicular fluid during follicular development. Biochem Biophys Res Commun 1987; 147:242–7.

    Article  PubMed  CAS  Google Scholar 

  36. Skinner MK, Lobb D, Dorrington JH. Ovarian thecal/interstitial cells produce an epidermal growth factor-like substance. Endocrinology 1987; 121:1892–9.

    Article  PubMed  CAS  Google Scholar 

  37. Kudlow JE, Kobrin MS, Purchio AF, et al. Ovarian transforming growth factor-alpha gene expression: immunohistochemical localization to the theca-interstitial cells. Endocrinology 1987; 121:1577–9.

    Article  PubMed  CAS  Google Scholar 

  38. Lobb DK, Skinner MK, Dorrington JH. Rat thecal/interstitial cells produce a mitogenic activity that promotes the growth of granulosa cells. Mol Cell Endocrinol 1988; 55:209–17.

    Article  PubMed  CAS  Google Scholar 

  39. Jones PBC, Welsh TH Jr, Hsueh AJW. Regulation of ovarian progestin production by epidermal growth factor in cultured rat granulosa cells. J Biol Chem 1982; 257:11268–73.

    PubMed  CAS  Google Scholar 

  40. Feng P, Knecht M, Catt KJ. Hormonal control of epidermal growth factor receptors by gonadotropins during granulosa cell differentiation. Endocrinology 1987; 120:1121–6.

    Article  PubMed  CAS  Google Scholar 

  41. Buck PA, Schomberg DW. [125I]iodo-epidermal growth factor binding and mitotic responsiveness of porcine granulosa cells are modulated by differentiation and follicle-stimulating hormone. Endocrinology 1988; 122:28–33.

    Article  PubMed  CAS  Google Scholar 

  42. May JV, Buck PA, Schomberg DW. Epidermal growth factor enhances [I]iodo-follicle stimulating hormone binding by cultured porcine granulosa cells. Endocrinology 1987; 120:2413–20.

    Article  PubMed  CAS  Google Scholar 

  43. Roy SK, Greenwald GS. Quantitative analysis of in vitro incorporation of [H]thymidine into hamster follicles during the oestrous cycle. J Reprod Fert 1986; 77:143–52.

    Article  CAS  Google Scholar 

  44. Hirshfield AN, Schmidt WA. Kinetic aspects of follicular development in the rat. In: Mahesh VB, Dhindsa DS, Anderson E, Kalia SP, eds. Regulation of ovarian and testicular function. New York: Plenum, 1987:211–36.

    Chapter  Google Scholar 

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Author information

Authors and Affiliations

  1. Departments of Obstetrics and Gynecology and Cell Biology, Duke University Medical Center, Durham, NC, 27710, USA

    David W. Schomberg

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  1. David W. Schomberg
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Editors and Affiliations

  1. University of Maryland, Baltimore, Maryland, USA

    Anne N. Hirshfield

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© 1989 Plenum Press, New York

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Schomberg, D.W. (1989). Growth Factor-Gonadotropin Interactions in Ovarian Cells. In: Hirshfield, A.N. (eds) Growth Factors and the Ovary. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-5688-2_10

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  • DOI: https://doi.org/10.1007/978-1-4684-5688-2_10

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4684-5690-5

  • Online ISBN: 978-1-4684-5688-2

  • eBook Packages: Springer Book Archive

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