Abstract
Insulin and the insulin—like growth factors (IGFs) have a diverse and complicated array of functions in endothelial cells, smooth muscle cells and fibroblasts, three major cell components of the arterial wall. In this chapter, we will review the in vitro studies assessing insulin/IGF effects on these three cell types and introduce other factors which may modulate the action of insulin/IGF on the arterial wall both in normal physiology and in the disease process atherosclerosis.
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References
R. S. Bar and M. Boes, Distinct receptors for IGF—I, IGF—II, and insulin are present on bovine capillary endothelial cells and large vessel endothelial cells. Biochem. Biophys. Res. Comm. 124:203 (1984).
B. Pfeifle and H. Ditschuneit, Receptors for insulin and insulin-like growth factor in cultured arterial smooth muscle cells depend on their growth state. J. Endocr. 96:251 (1983).
M. M. Rechler and J. M. Podskalny, Insulin receptors in cultured human fibroblasts, Diabetes 25:250 (1976).
G. L. King, A. D. Goodman, S. Buzney, A. Moses, and C. R. Kahn, Receptors and growth-promoting effects of insuiln and insulin-like growth factors on cells from bovine retinal capillaries and aorta. J. Clin. Invest. 75:1028 (1985).
R. S. Bar, K. Siddle, S. Dolash, M. Boes, and B. Dake, Actions of insulin and insulin—like growth factors I and II in cultured micro ves sel endothelial cells from bovine adipose tissue. Metabolism 37:714 (1988).
A. J. Cox, R. S. Bar, H. A. Jonas, and J. D. Newman, Atypical receptors for insulin-like peptides in endothelial cells. Diabetes 36:54A (1987).
R. S. Bar, M. Boes, B.L. Dake, B. A. Booth, and S. A. Henley, Insulin, insulin—like growth factors and vascular endothelium, Am. J. Med. 85 (Suppl. 5A):59 (1988).
M. E. Gerritsen and T. M. Burke, Insulin binding and effects of insuiln on glucose uptake and metabolism in cultured rabbit coronary microvessel endothelium. Proc. Soc. Exp. Biol. Med. 180:17 (1985).
G. L. King, S. Buzney, C. R. Kahn, N. Hetu, S. Buchwald, S. G. Macdonald, and L. I. Rand, Differential responsiveness to insulin in endothelial and support cells from micro— and macrovessels. J. Clin. Invest. 71:974 (1983).
R. S. Bar, B. L. Dake, and S. Stueck, Stimulation of proteoglycans by IGF—I and IGF—II in microvessel and large vessel endothelial cells. Am. J. Physiol. 253:E21 (1987).
J. Foster, C. B. Rich, and J. R. Florini, Insulin—like growth factor I, somatomedin C, induces the synthesis of tropoelastin in aortic tissue, Collagen Rel. Res. 7:161 (1987).
G. L. King, C. R. Kahn, M. M. Rechler, and S. P. Nissley, Direct demonstration of separate receptors for growth and metabolic activities of insulin and multiplication—stimulating activity (an insulin—like growth factor) using antibodies to the insulin receptor. J. Clin. Invest. 66:130 (1980).
G. L. King, N. B. Banskota, and R. Taub, Additivity effects of PDGF and insulin on the stimulation of proto—oncogene c—myc and cellular growth in aortic smooth muscle cells, Abstract presented at the American Diabetes Association’s 23rd International Research Symposium “Diabetes, Lipoproteins, and Atherosclerosis” (1989).
D. R. Clemmons, Interaction of circulating cell—derived and plasma growth factors in stimulating cultured smooth muscle cell replication, J. Cell. Physiol. 121:425 (1984).
R. Ross, E. W. Raines and D. F. BowenPope, The biology of platelet derived growth factor, Cell 46:155 (1986).
T. O. Daniel, V. C. Gibbs, D. F. Milfay, and L. T. Williams, Agents that increase cAMP accumulation block endothelial c—sis induction by thrombin and transforming growth factor—β, J. Biol. Chem. 262:11893 (1987).
D. R. Clemmons, J. J. Van Wyke, and W. J. Pledger, Sequential addition of platelet factor and plasma to BALB/C3T3 fibroblast cultures stimulates somatomedin—C binding early in cell cycle. Proc. Natl. Acad. Sci. USA 77:6644 (1980).
D. R. Clemmons, Variables controlling the secretion of somatomedin—like peptide by cultured porcine smooth muscle cells. Circ. Res. 56:418, (1985).
D. R. Clemmons and J. J. van Wyk, Evidence for a functional role of endogenously produced somatomedinlike peptides in the regulation of DNA synthesis in cultured human fibroblasts and procine smooth muscle cells. J. Clin. Invest. 75:1914, (1985).
B. Pfeifle, H. Boeder, and H. Ditschuneit, Interaction of receptors for insulinlike growth factor I, platelet—derived growth factor, and fibroblast growth factor in rat aortic cells, Endocrinology 120:2251 (1987).
I. Vlodavsky, R. Fridman, R. Sullivan, J. Sasse, and M. Klagsbrun, Aortic endothelial cells synthesize basic fibroblast growth factor which remains cell associated and platelet—derived growth factor—like protein which is secreted, J. Cell. Physiol. 131:402 (1987).
J. Zapf and E. R. Froesch, Insulin—like growth factors/somatomedins: Structure, secretion, biological actions and physiological role, Hormone Res. 24:121 (1986).
V. K. M. Han, A. J. D’Ercole and P. K. Lund, Cellular localization of somatomedin (insulin-like growth factor) messenger RNA in the human fetus, Science 236:193 (1987).
H-A Hansson, E. Jennische, and A. Skottner, Regenerating endothelial cells express insulin-like growth factor-I immunoreactivity after arterial injury, Cell Tissue Res. 250:499 (1987).
D. R. Clemmons, L. E. Underwood, and J. J. Van Wyk, Hormonal control of immunoreactive somatomedin production by cultured human fibroblasts. J. Clin. Invest. 67:10 (1981).
W. I. Wood, G. Cachianes, W. J. Henzel, G. A. Winslow, S. A. Spencer, R. Hellmiss, J. L. Martin, and R. C. Baxter, Cloning and expression of the growth hormone—dependent insulin—like growth factor—binding protein, Mol. Endo. 2:1176 (1988).
R. S. Bar, L. C. Harrison, R. C. Baxter, M. Boes, B. L. Dake, B. Booth, and A. Cox, Production of IGF—binding proteins by vascular endothelial cells. Biochem. Biophys. Res. Comm. 148:734 (1987).
A. Brinkman, C. Groffen, D. J. Kortleve, A. G. van Kessel, and S. L. S. Drop, Isolation and characterization of a cDNA encoding the low molecular weight insulin—like growth factor binding protein (IPB—1), EMBO Journal 7:2417 (1988).
R. G. Elgin, W. H. Busby, Jr., and D. R. Clemmons, An insulin—like growth factor (IGF) binding protein enhances the biologic response to IGF—I, Proc. Natl. Acad. Sci. USA 84:3254 (1987).
R. S. Bar, B. A. Booth, M. Boes, and B. L. Dake, IGF—binding proteins from vascular endothelial cells: Purification, characterization and intrinsic biological activities, Endocrinology, submitted (1989).
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© 1989 Plenum Press, New York
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Bar, R.S., Lowe, W.L., Spanheimer, R.G. (1989). Interactions of Insulin and IGFS with Cellular Components of the Arterial Wall: Potential Impact on Atherosclerosis. In: LeRoith, D., Raizada, M.K. (eds) Molecular and Cellular Biology of Insulin-like Growth Factors and Their Receptors. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-5685-1_40
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DOI: https://doi.org/10.1007/978-1-4684-5685-1_40
Publisher Name: Springer, Boston, MA
Print ISBN: 978-1-4684-5687-5
Online ISBN: 978-1-4684-5685-1
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