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Interaction of IGF with the Hypothalamus and Pituitary

  • Chapter
Molecular and Cellular Biology of Insulin-like Growth Factors and Their Receptors

Abstract

Postnatal growth, regulated by pituitary growth hormone, and mediated by IGF-I, is controlled by the central nervous system. The mechanisms underlying the regulation of this system are under intense study in many laboratories. By analogy with other pituitary hormones, GH secretion may be controlled by negative feedback, either by GH itself, or by the IGFs produced in diverse tissues in response to GH.1 This feedback signal may be received by the hypothalamus, the pituitary gland, or possibly by higher brain centers. Responses to these regulatory signals would necessarily require mediation by specific receptors for IGFs. Such receptors have been localized and characterized within both the hypothalamus and pituitary gland; the results of these studies are reviewed herein.

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Authors and Affiliations

  1. Departments of Pediatrics and Medicine, Stanford University School of Medicine, Stanford, CA, USA

    Ron G. Rosenfeld, Ian Ocrant, Karen L. Valentino & Andrew R. Hoffman

  2. Neurex Corporation, Menlo Park, CA, USA

    Andrew R. Hoffman

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  1. Ron G. Rosenfeld
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  2. Ian Ocrant
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Editors and Affiliations

  1. National Institutes of Health, Bethesda, Maryland, USA

    Derek LeRoith

  2. University of Florida, Gainesville, Florida, USA

    Mohan K. Raizada

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Rosenfeld, R.G., Ocrant, I., Valentino, K.L., Hoffman, A.R. (1989). Interaction of IGF with the Hypothalamus and Pituitary. In: LeRoith, D., Raizada, M.K. (eds) Molecular and Cellular Biology of Insulin-like Growth Factors and Their Receptors. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-5685-1_4

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