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Molecular and Cellular Biology of Insulin-like Growth Factors and Their Receptors pp 359–367Cite as

The Insulin-Like Growth Factor-II/Mannose 6-Phosphate Receptor

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Abstract

Competitive binding experiments first demonstrated that insulin-like growth factor (IGF) receptors are distinct from insulin receptors and that there are two IGF receptors based on relative preference for IGF-I, IGF-II, and insulin1. The IGF-I receptor or type I IGF receptor binds IGF-I with higher affinity than IGF-II, and binds insulin with much lower affinity than IGF-II. The IGF-II receptor or type II IGF receptor binds IGF-II with considerably higher affinity than IGF-I and does not bind insulin at all. The structures of these two IGF receptors were defined by affinity crosslinking, biosynthetic labeling, purification, and finally, molecular cloning2–5. The IGF-I receptor is very similar to the insulin receptor, consisting of two alpha subunits of 130 kDa, and two beta subunits of 95 kDa. The beta subunit has intrinsic tyrosine kinase activity which is activated by autophosphorylation following ligand binding to the alpha subunit. The structure of the IGF-II receptor is quite different from the structure of the IGF-I receptor. The IGF-II receptor is a single 250 kDa glycoprotein which lacks tyrosine kinase activity.

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Author information

Authors and Affiliations

  1. Endocrinology Section, Metabolism Branch, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA

    Peter Nissley, Wieland Kiess & Mark Sklar

Authors
  1. Peter Nissley
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  2. Wieland Kiess
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  3. Mark Sklar
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Editors and Affiliations

  1. National Institutes of Health, Bethesda, Maryland, USA

    Derek LeRoith

  2. University of Florida, Gainesville, Florida, USA

    Mohan K. Raizada

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© 1989 Plenum Press, New York

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Nissley, P., Kiess, W., Sklar, M. (1989). The Insulin-Like Growth Factor-II/Mannose 6-Phosphate Receptor. In: LeRoith, D., Raizada, M.K. (eds) Molecular and Cellular Biology of Insulin-like Growth Factors and Their Receptors. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-5685-1_30

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  • DOI: https://doi.org/10.1007/978-1-4684-5685-1_30

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4684-5687-5

  • Online ISBN: 978-1-4684-5685-1

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