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Role of IGFs in Growth Hormone Homeostasis

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Molecular and Cellular Biology of Insulin-like Growth Factors and Their Receptors

Abstract

The classic postulate by Harris of neuroendocrine control of the anterior pituitary gland predicted that factors would be identified within the hypothalamus that were transported via capillaries of the hypophyseal-portal vessels to regulate pituitary hormone secretion. Two such factors have recently been identified that regulate growth hormone secretion — growth hormone releasing factor (GRF) (1) and the inhibitory peptide, somatostatin (SRIF) (2) (Fig 1). SRIF is widely synthesized and distributed through the hypothalamus and extra-hypothalamic brain (3). Somatostatinergic neurons that originate in perikarya in the periventricular nucleus of the hypothalamus have axons that project via the retrochiasmatic region to terminate in nerve endings in the external layer of the median eminence (4). Manipulation of growth hormone and steroid hormone homeostasis influence preprosomatostatin mRNA (5,6) and SRIF content (7) primarily in this pathway and lesions along the pathway deplete the median eminence of SRIF (8). It thus appears likely that this tract represents the hypophysiotropic somatostatinergic pathway.

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Author information

Authors and Affiliations

  1. Endocrine Div; HSC T15, 060, State University of New York, Stony Brook, New York, 11794, USA

    Michael Berelowitz

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  1. Michael Berelowitz
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Editors and Affiliations

  1. National Institutes of Health, Bethesda, Maryland, USA

    Derek LeRoith

  2. University of Florida, Gainesville, Florida, USA

    Mohan K. Raizada

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© 1989 Plenum Press, New York

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Berelowitz, M. (1989). Role of IGFs in Growth Hormone Homeostasis. In: LeRoith, D., Raizada, M.K. (eds) Molecular and Cellular Biology of Insulin-like Growth Factors and Their Receptors. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-5685-1_3

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  • DOI: https://doi.org/10.1007/978-1-4684-5685-1_3

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4684-5687-5

  • Online ISBN: 978-1-4684-5685-1

  • eBook Packages: Springer Book Archive

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