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Hormonal Feedback Regulation of Brain IGF-I and IGF-II Gene Expression

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Molecular and Cellular Biology of Insulin-like Growth Factors and Their Receptors

Abstract

Release of anterior pituitary hormones is mediated by peptides produced by secretory neurons in the hypothalamus or preoptic area. The releasing or inhibiting factors are stored in nerve endings that lie in the median eminence and are secreted as the result of electrical activity. The hypothalamic peptides then travel through the portal system to the anterior pituitary where they interact with specific surface receptors to trigger release of pituitary trophic hormones. These, in turn, regulate physiologic processes elsewhere in the body either directly or indirectly through release of target gland hormones.

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Author information

Authors and Affiliations

  1. Department of Neurobiology and Behavior, SUNY at Stony Brook, Stony Brook, N. Y., USA

    Teresa L. Wood & Michael Berelowitz

  2. Abbott Laboratories, Abbott Park, Illinois, USA

    Jeffrey F. McKelvy

Authors
  1. Teresa L. Wood
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  2. Michael Berelowitz
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  3. Jeffrey F. McKelvy
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Editor information

Editors and Affiliations

  1. National Institutes of Health, Bethesda, Maryland, USA

    Derek LeRoith

  2. University of Florida, Gainesville, Florida, USA

    Mohan K. Raizada

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© 1989 Plenum Press, New York

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Wood, T.L., Berelowitz, M., McKelvy, J.F. (1989). Hormonal Feedback Regulation of Brain IGF-I and IGF-II Gene Expression. In: LeRoith, D., Raizada, M.K. (eds) Molecular and Cellular Biology of Insulin-like Growth Factors and Their Receptors. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-5685-1_18

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  • DOI: https://doi.org/10.1007/978-1-4684-5685-1_18

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4684-5687-5

  • Online ISBN: 978-1-4684-5685-1

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