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Molecular and Cellular Biology of Insulin-like Growth Factors and Their Receptors pp 179–193Cite as

Expression of Insulin-Like Growth Factors by the Human Placenta

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Abstract

The placenta is an extraembryonic structure that participates in the protection and maintenance of the developing conceptus. To function in this capacity, the placenta exhibits the characteristics of many adult mammalian tissue and organ level regulatory systems. It is, therefore, not surprising that the placenta has been shown to produce effector molecules either identical or similar to those expressed by adult neural, endocrine, and immunologic cells. Furthermore, receptor molecules capable of binding and allowing cells to respond to various effector molecules (including many of those produced by the placenta) have been demonstrated to be present in placental membranes. Thus, local hormonal networks may be postulated to exist within the placenta that can regulate its various functions and its own growth and development. One such autocrine/paracrine network that has been postulated for the human placenta is the insulin-like growth factor-I and -II (IGF-I and -II) system. As we have concentrated much of our research effort in recent years on examining the expression of the IGF-I and -II genes in the human placenta, this review will provide a brief recapitulation of that work presented in conjunction with the results of others working on this placental local hormonal system.

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References

  • Adams, P.A.J., Teramo, K., Raiha, N., Gitlin, D., and Schwartz, R., 1969, Human fetal insulin metabolism early in gestation: response to acute elevation of the fetal glucose concentration and placental transfer of human [131I] insulin, Diabetes. 18:409.

    Google Scholar 

  • Adams, S.O., Nissley, S.P., Handwerger, S., and Rechler, M.M., 1983a, Developmental patterns of insulin-like growth factor I and II synthesis and regulation in rat fibroblasts, Nature (London). 302:150.

    Article  CAS  Google Scholar 

  • Adams, S.O., Nissley, S.P., Greenstein, L.A., Yang, T.W.-H., and Rechler, M.M., 1983b, Synthesis of multiplication-stimulating activity (rat insulin-like growth factor II) by rat embryo fibroblasts, Endocrinol., 112:979.

    Article  CAS  Google Scholar 

  • Ashton, I.K., and Francis, M.J.O., 1978, Response of chondrocytes isolated from human foetal cartilage to plasma somatomedin activity, J. Endocrinol.. 76:473.

    Article  PubMed  CAS  Google Scholar 

  • Ashton, I.K., and Vesey, J., 1978, Somatomedin activity in human cord plasma and relationship to birth size, insulin, growth hormone, and prolactin, Early Hum. Develop., 2:115.

    Article  CAS  Google Scholar 

  • Bassas, L., DePalo, F., Lesniak, M.A., and Roth, J., 1985, Ontogeny of receptors for insulin-like peptides in chick embryo tissues: early dominance of insulin-like growth factor over insulin receptors in brain. Endocrinol., 117:2321.

    Article  CAS  Google Scholar 

  • Baxter, R.C., and DeMellow, J.S.M., 1986, Measurement of insulin-like growth factor-II by radioreceptor assay using ovine placental membranes, Clin. Endocrinol., 24:267.

    Article  CAS  Google Scholar 

  • Bell, G.I., Merryweather, J.P., Sanchez-Pescador, R., Stempien, M.M., Priestley, L., Scott, J., and Rall, L.B., 1984, Sequence of a cDNA clone encoding human preproinsulin-like growth factor II, Nature (London). 310:775.

    Article  CAS  Google Scholar 

  • Bennett, A., Wilson, D.M., Liu, F., Nagashima, R., Rosenfeld, R.G., and Hintz, R.L., 1983, Levels of insulin-like growth factor I and II in human cord blood, J. Clin. Endocrinol. Metabol., 57:609.

    Article  CAS  Google Scholar 

  • Bhaumick, B., and Bala, R.M., 1984, Basic somatomedin (B-SM) receptors in human term placenta expiants, Biochem. Biophys. Res. Comm., 122:583.

    Article  PubMed  CAS  Google Scholar 

  • Bhaumick, B., Bala, R.M., and Hollenberg, M.D., 1981, Somatomedin receptor of human placenta: solubilization, photolabeling, partial purification, and comparison with insulin receptor, Proc. Natl. Acad. Sci. USA. 78:4279.

    Article  PubMed  CAS  Google Scholar 

  • Bhaumick, B., Armstrong, G.D., Hollenberg, M.D., and Bala, R.M., 1982, Characterization of the human placental receptor for basic somatomedin, Can. J. Biochem., 60:923.

    Article  PubMed  CAS  Google Scholar 

  • Bhaumick, B., Dawson, E.P., and Bala, R.M., 1987, The effects of insulinlike growth factor-I and insulin on placental lactogen production by human term placental expiants, Biochem. Biophys. Res. Comm., 144:674.

    Article  PubMed  CAS  Google Scholar 

  • Boime, I., Boothby, M., Hoshina, M., Daniels-McQueen, S., and Darnell, R., 1982, Expression and structure of human placenta1, hormone genes as a function of placental development, Biol. Reproduct., 26:73.

    Article  CAS  Google Scholar 

  • Cara, J.F., Nakagawa, S.H., and Tager, H.S., 1988, Structural determinants of ligand recognition by type I insulin-like growth factor receptors: use of semisynthetic insulin analog probes, Endocrinol., 122:2881.

    Article  CAS  Google Scholar 

  • Chernausek, S.D., Jacobs, S., and Van Wyk, J.J., 1981, Structural similarities between human receptors for somatomedin C and insulin: analysis by affinity labeling, Biochem.. 20:7345.

    Article  CAS  Google Scholar 

  • Daughaday, W.H., Mariz, I.K., and Trivedi, B., 1981, A preferential binding site for insulin-like growth factor II in human and rat placental membranes, J. Clin. Endocrinol. Metabol., 53:282.

    Article  CAS  Google Scholar 

  • D’Ercole, A.J., Applewhite, G.T., and Underwood, L.E., 1980, Evidence that somatomedin is synthesized by multiple tissues in the fetus, Develop. Biol., 75:315.

    Article  PubMed  Google Scholar 

  • Fant, M., Munro, H., and Moses, A.C., 1986, An autocrine/paracrine role for insulin-like growth factors in the regulation of human placental growth, J. Clin. Endocrinol. Metabol., 63:499.

    Article  CAS  Google Scholar 

  • Fant, M., Munro, H., and Moses, A.C., 1988, Production of insulin-like growth factor binding protein(s) (IGF-BPs) by human placenta: variation with gestational age, Placenta. 9:397.

    Article  PubMed  CAS  Google Scholar 

  • Feltz, S.M., Swanson, M.L., Wemmie, J.A., and Pessin, J.E., 1988, Functional properties of an isolated aB heterodimeric human placenta insulin-like growth factor 1 receptor complex, Biochem., 27:3234.

    Article  CAS  Google Scholar 

  • Frankenne, F., Rentier-Debrue, F., Scippo, M.-L., Martial, J., and Henner, G., 1987, Expression of the growth hormone variant gene in human placenta, J. Clin. Endocrinol. Metabol., 64:635.

    Article  CAS  Google Scholar 

  • Furlanetto, R.W., Underwood, L.E., Van Wyk, J.J., and Handwerger, S., 1978, Serum immunoreactive somatomedin-C is elevated late in pregnancy, J. Clin. Endocrinol. Metabol., 47:695.

    Article  CAS  Google Scholar 

  • Goustin, A.S., Betsholz, C., Pfiefer-Ohlsson, S., Persson, H., Rydnert, J., Bywater, M., Holmgren, G., Heldin, C.-H., Westermark, B., and Ohlsson, R., 1985, Coexpression of the sis and myc proto-oncogenes in developing human placenta suggests autocrine control of trophoblast growth, Cell. 41:301.

    Article  PubMed  CAS  Google Scholar 

  • Grizzard, J.D., D’Ercole, A.J., Wilkins, J.R., Moats-Staats, B.M., and Williams, R.W., 1984, Affinity-labeled somatomedin-C receptors and binding proteins from the human fetus, J. Clin. Endocrinol. Metabol.. 58:535.

    Article  CAS  Google Scholar 

  • Han, V.K.M., D’Ercole, A.J., and Lund, P.K., 1987, Cellular localization of somatomedin (insulin-like growth factor) messenger RNA in the human fetus, Science. 236:193.

    Article  PubMed  CAS  Google Scholar 

  • Henner, G., Frankenne, F., Pirens, G., Gomez, F., Closset, J., Schaus, C.H., and El Khayat, N., 1985, New chorionic GH-like antigen revealed by monoclonal antibody radioimmunoassays, Lancet. 16:399.

    Article  Google Scholar 

  • Hill, D.J., Grace, C.J., Nissley, S.P., Morrell, D., Holder, A.T., and Milner, R.D.G., 1985, Fetal rat myoblasts release both rat somatomedin-C (SM-C)/insulin -like growth factor I (IGF I) and multiplication-stimulating activity in vitro: partial characterization and biological activity of myoblast-derived SM-C/IGF-I, Endocrinol., 117:2061.

    Article  CAS  Google Scholar 

  • Höppener, J.W.M., Mosselman, S., Roholl, P.J.M., Lambrechts, C., Slebos, R.J.C., de Pagter-Holthuizen, P., Lips, C.J.M., Jansz, H.S., and Sussenbach, J.S., 1988, Expression of insulin-like growth factor-I and-II genes in human smooth muscle tumours, EMBO J., 7:1379.

    PubMed  Google Scholar 

  • Jansen, M., van Schaik, F.M.A., van Tol, H., Van den Brande, J.L., and Sussenbach, J.S., 1985, Nucleotide sequences of cDNAs encoding precursors of human insulin-like growth factor II (IGF-II) and an IGF-II variant, FEBS Lett.. 179:243.

    Article  PubMed  CAS  Google Scholar 

  • Jonas, H.A., 1988, Heterogeneity of receptors for insulin and insulin-like growth factor I: evidence for receptor subtypes, in: “Insulin Receptors Part B: Clinical Assessment, Biological Responses, and Comparison to the IGF-I Receptor,” CR. Kahn and L.C. Harrison, eds., Alan R. Liss, New York.

    Google Scholar 

  • Jonas, H.A., Newman, J.D., and Harrison, L.C., 1986, An atypical insulin receptor with high affinity for insulin-like growth factors copurified with placental insulin receptors, Proc. Natl. Acad. Sci. USA. 83:4124.

    Article  PubMed  CAS  Google Scholar 

  • Kalhan, S.C., Schwartz, R., and Adams, P.A.J., 1975, Placental barrier to human insulin- 125I in insulin-dependent diabetic mothers, J. Clin. Endocrinol. Metabol. 40:139.

    Article  CAS  Google Scholar 

  • Kaplowitz, P.B., D’Ercole, A.J., and Underwood, L.E., 1982, Stimulation of embryonic mouse limb bud mesenchymal cell growth by peptide growth factors, J. Cell. Physiol., 112:353.

    Article  PubMed  CAS  Google Scholar 

  • Koistinen, R., Kalkkinen, N., Huhtala, M.-L., Seppälä, M., Bohn, H., and Rutanen, E.-M., 1986, Placental protein 12 is a decidual protein that binds somatomedin and has an identical N-terminal amino acid sequence with somatomedin-binding protein from human amniotic fluid, Endocrinol., 118:1375.

    Article  CAS  Google Scholar 

  • LeBouc, Y., Noguiez, P., Sondermeijer, P., Dreyer, D., Girard, F., and Binoux, M., 1987, A new 5′-non-coding region for human placental insulin-like growth factor II mRNA expression, FEBS Lett.. 222:181.

    Article  CAS  Google Scholar 

  • Liebhaber, S.A., Urbanek, M., Ray, J., Tuan, R.S., and Cooke, N.E., 1989, Characterization and histologic localization of human growth hormone-variant gene expression in the placenta, J. Clin. Invest., 83:1985.

    Article  PubMed  CAS  Google Scholar 

  • Liu, K.-S., Wang, C.-Y., Mills, N., Gyves, M., and Ilan, J., 1985, Insulin-related genes expressed in human placenta from normal and diabetic pregnancies, Proc. Natl. Acad. Sci. USA. 82:3868.

    Article  PubMed  CAS  Google Scholar 

  • Lund, P.K., Moats-Staats, B.M., Hynes, M.A., Simmons, J.G., Jansen, M., D’Ercole, A.J., and Van Wyk, J.J., 1986, Somatomedin-C/insulinlike growth factor-I and insulin-like growth factor-II mRNAs in rat fetal and adult tissues, J. Biol. Chem., 261:14539.

    PubMed  CAS  Google Scholar 

  • Maly, P., and Liithi, C., 1986a, Purification of the type I insulin-like growth factor receptor from human placenta, Biochem. Biophys. Res. Comm., 137:695.

    Article  CAS  Google Scholar 

  • Maly, P., and Liithi, C., 1986b, Characterization of affinity-purified type I insulin-like growth factor receptor from human placenta, Biochem. Biophys. Res. Comm., 138:1257.

    Article  PubMed  CAS  Google Scholar 

  • Marshall, R.N., Underwood, L.E., Voina, S.J., Foushee, D.B., and Van Wyk, J.J., 1974, Characterization of the insulin and somatomedin-C receptors in human placental cell membranes, J. Clin. Endocrinol. Metabol., 39:283.

    Article  CAS  Google Scholar 

  • Massagué, J., and Czech, M.P., 1982, The subunit structures of two distinct receptors for insulin-like growth factors I and II and their relationship to the insulin receptor, J. Biol. Chem., 257:5038.

    PubMed  Google Scholar 

  • Mattson, B.A., Rosenblum, I.Y., Smith, R.M., and Heyner, S., 1988, Autoradiographic evidence for insulin and insulin-like growth factor binding to early mouse embryos, Diabetes. 37:585.

    Article  PubMed  CAS  Google Scholar 

  • Merimee, T.J., Zapf, J., and Froesch, E.R., 1982, Insulin-like growth factor in pregnancy: studies in a growth hormone-deficient dwarf, J. Clin. Endocrinol. Metabol., 54:1101.

    Article  CAS  Google Scholar 

  • Mills, N.C., D’Ercole, A.J., Underwood, L.E., and Ilan, J., 1986, Synthesis of somatomedin C/insulin-like growth factor I by human placenta, Molec. Biol. Rep., 11:231.

    Article  CAS  Google Scholar 

  • Murphy, L.J., Bell, G.I., and Friesen, H.G., 1987a, Tissue distribution of insulin-like growth factor I and II messenger ribonucleic acid in the adult rat, Endocrinol. 120:1279.

    Article  CAS  Google Scholar 

  • Murphy, L.J., Murphy, L.C., and Friesen, H.G., 1987b, Estrogen induces insulin-like growth factor-I expression in the rat uterus, Molec. Endocrinol.. 1:445.

    Article  CAS  Google Scholar 

  • Pekonen, F., Suikkari, A.-M., Mäkinen, T., and Rutanen, E.-M., 1988, Different insulin-like growth factor binding species in human placenta and decidua, J. Clin. Endocrinol. Metabol.. 67:1250.

    Article  CAS  Google Scholar 

  • Pilch, P.F., O’Hare, T., Rubin, J., and Boni-Schnetzler, M., 1986, The ligand binding subunit of the insulin-like growth factor 1 receptor has properties of a peripheral membrane protein, Biochem. Biophys. Res. Comm., 136:45.

    Article  PubMed  CAS  Google Scholar 

  • Pilistine, S.J., Moses, A.C., and Munro, H.N., 1984a, Insulin-like growth factor receptors in rat placental membranes, Endocrinol., 115:1060.

    Article  CAS  Google Scholar 

  • Pilistine, S.J., Munro, H., and Moses, A.C., 1984b, Placental lactogen administration reverses the effect of low protein diet on maternal-fetal serum somatomedin levels in the pregnant rat, Proc. Natl. Acad. Sci. USA. 81:5853.

    Article  PubMed  CAS  Google Scholar 

  • Read, L.C., Ballard, F.J., Francis, G.L., Baxter, R.C., Bagley, C.J., and Wallace, J.C., 1986, Comparative binding of bovine, human and rat insulin-like growth factors to membrane receptors and to antibodies against human insulin-like growth factor-1, Biochem. J. 233:215.

    PubMed  CAS  Google Scholar 

  • Reeve, A.E., Eccles, M.R., Wilkins, R.J., Bell, G.I., and Millow, L.J., 1985, Expression of insulin-like growth factor-II transcripts in wilms’ tumour, Nature (London). 317:258.

    Article  CAS  Google Scholar 

  • Ritvos, O., Ranta, T., Jalkanen, J., Suikkari, A.-M., Voutilainen, R., Bohn, H., and Rutanen, E.-M., 1988, Insulin-like growth factor (IGF) binding protein from human decidua inhibits the binding and biological action of IGF-I in cultured choriocarcinoma cells, Endocrinol.. 122:2150.

    Article  CAS  Google Scholar 

  • Rutanen, E.-M., Pekonen, F., and Mäkinen, T., 1988, Soluble 34K binding protein inhibits the binding of insulin-like growth factor I to its cell receptors in human secretory phase endometrium: evidence for autocrine/paracrine regulation of growth factor action, J. Clin. Endocrinol. Metabol.. 66:173.

    Article  CAS  Google Scholar 

  • Sahal, D., Ramachandran, J., and Fujita-Yamaguchi, Y., 1988, Specificity of tyrosine protein kinases of the structurally related receptors for insulin and insulin-like growth factor I: tyr-containing synthetic polymers as specific inhibitors or substrates, Arch. Biochem. Biophys.. 260:416.

    Article  PubMed  CAS  Google Scholar 

  • Sara, V.R., Hall, K., Misaki, M., Frykland, L., Christensen, N., and Wetterberg, L., 1983, Ontogenesis of somatomedin and insulin receptors in the human fetus, J Clin. Invest., 71:1084.

    Article  PubMed  CAS  Google Scholar 

  • Sara, V.R., and Carlsson-Skwirut, C., 1986, The biosynthesis of somatomedins and their role in the fetus, Acta Endocrinol. (Copenh.). 113 (Suppl. 279):82.

    CAS  Google Scholar 

  • Scott, J., Cowell, J., Robertson, M.E., Priestley, L.M., Wadey, R., Hopkins, B., Pritchard, J., Bell, G. I., Rall, L.B., Graham, C.F., and Knott, T.J., 1985, Insulin-like growth factor-II gene expression in wilms’ tumour and embryonic tissues, Nature (London). 317:260.

    Article  CAS  Google Scholar 

  • Shen, S.-J., Wang, C.-Y., Nelson, K.K., Jansen, M., and Ilan, J., 1986, Expression of insulin-like growth factor II in human placentas from normal and diabetic pregnancies, Proc. Natl. Acad. Sci. USA. 83: 9179.

    Article  PubMed  CAS  Google Scholar 

  • Shen, S.-J., Daimon, M., Wang, C.-Y., Jansen, M., and Ilan, J., 1988, Isolation of an insulin-like growth factor II cDNA with a unique 5′ untranslated region from human placenta, Proc. Natl. Acad. Sci. USA, 85:1947.

    Article  PubMed  CAS  Google Scholar 

  • Stempien, M.M., Fong, N.M., Rall, L.B., and Bell, G.I., 1986, Sequence of a placental cDNA encoding the mouse insulin-like growth factor II precursor, DNA. 5:357.

    Article  PubMed  CAS  Google Scholar 

  • Strain, A.J., Hill, D.J., Swenne, L, and Milner, R.D.G., 1987, Regulation of DNA synthesis in human fetal hepatocytes by placental lactogen, growth hormone, and insulin-like growth factor I/somatomedin-C, J. Cell. Physiol., 132:33.

    Article  PubMed  CAS  Google Scholar 

  • Swenne, I., Hill, D.J., Strain, A.J., and Milner, R.D.G., 1987, Growth hormone regulation of somatomedin C/insulin-like growth factor I production and DNA replication in fetal rat islets in tissue culture, Diabetes. 36:288.

    Article  PubMed  CAS  Google Scholar 

  • Tavakkol, A., Simmen, F.A., and Simmen, R.C.M., 1988, Porcine insulinlike growth factor-I (pIGF-I): complementary deoxyribonucleic acid cloning and uterine expression of messenger ribonucleic acid encoding evolutionarily conserved IGF-I peptides, Molec. Endocrinol., 2:674.

    Article  CAS  Google Scholar 

  • Taylor, R.N., and Williams, L.T., 1988, Developmental expression of platelet-derived growth factor and its receptor in the human placenta, Molec. Endocrinol., 2: 627.

    Article  CAS  Google Scholar 

  • Thrailkill, K.M., Golander, A., Underwood, L.E., and Handwerger, S., 1988, Insulin-like growth factor I stimulates the synthesis and release of prolactin from human decidual cells, Endocrinol., 123:2930.

    Article  CAS  Google Scholar 

  • Underwood, L.E., D’Ercole, A.J., Furlanetto, R.W., Handwerger, S., and Hurley, T.W., 1979, Somatomedin and growth: a possible role for somatomedin-C in fetal growth, in “Somatomedin and Growth,” G. Giordano, J.J. Van Wyk, and F. Minuto, eds., Academic Press, New York.

    Google Scholar 

  • Wang, C.-Y., Daimon, M., Shen, S.-J., Engelmann, G.L., and Ilan, J., 1988, Insulin-like growth factor-I messenger ribonucleic acid in the developing human placenta and in term placenta of diabetics, Molec. Endocrinol., 2:217.

    Article  CAS  Google Scholar 

  • Younes, M.A., D’Agostino, J., and Besch, P.K., 1986, mRNA for insulinlike growth factor from human placenta, Alabama J. Med. Sci. 23:285.

    CAS  Google Scholar 

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Authors and Affiliations

  1. Departments of Reproductive Biology, Case Western Reserve University, Cleveland, Ohio, 44106, USA

    Keith D. Boehm, Michael F. Kelley & Judith Ilan

  2. Departments of Developmental Genetics and Anatomy, Case Western Reserve University, Cleveland, Ohio, 44106, USA

    Judith Ilan

  3. The Cancer Research Center, Case Western Reserve University, Cleveland, Ohio, 44106, USA

    Judith Ilan

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  1. Keith D. Boehm
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  2. Michael F. Kelley
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  3. Judith Ilan
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Editors and Affiliations

  1. National Institutes of Health, Bethesda, Maryland, USA

    Derek LeRoith

  2. University of Florida, Gainesville, Florida, USA

    Mohan K. Raizada

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© 1989 Plenum Press, New York

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Boehm, K.D., Kelley, M.F., Ilan, J. (1989). Expression of Insulin-Like Growth Factors by the Human Placenta. In: LeRoith, D., Raizada, M.K. (eds) Molecular and Cellular Biology of Insulin-like Growth Factors and Their Receptors. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-5685-1_16

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  • DOI: https://doi.org/10.1007/978-1-4684-5685-1_16

  • Publisher Name: Springer, Boston, MA

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