Abstract
Amongst potential novel intraovarian regulators, insulin-like growth factor I (IGF-I) has been the subject of increasingly intense investigation1. Taken together, these studies strongly suggest the existence of an intraovarian autocrine control mechanism, wherein IGF-I may serve as the central signal, and the granulosa cell its site of production, reception, and action. In doing so, IGF-I may promote the replication and/or cytodifferentiation of the developing granulosa cell, acting largely (but not exclusively) as an amplifier of gonadotropin action. Furthermore, IGF-I (presumptively of granulosa cell origin) may also provide paracrine input to the adjacent theca-interstitial cell compartment in the interest of coordinated follicular development.
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© 1989 Plenum Press, New York
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Adashi, E.Y., Resnick, C.E., Hernandez, E.R., Svoboda, M.E., Van Wyk, J.J. (1989). Ovarian Insulin-Like Growth Factor I: Basic Concepts Leading to Potential Clinical Outlets. In: LeRoith, D., Raizada, M.K. (eds) Molecular and Cellular Biology of Insulin-like Growth Factors and Their Receptors. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-5685-1_13
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DOI: https://doi.org/10.1007/978-1-4684-5685-1_13
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