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Calcium Protein Signaling pp 505–514Cite as

Disregulation of Cell Calcium and Calcium-Binding Proteins in Experimental Hypertension

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Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 255))

Abstract

Hypertension in experimental animal models is often associated with several distinct abnormalities in calcium metabolism from the level of the cell to the whole organism. The physiological and biochemical defects in the regulation of calcium include: low serum ionized calcium, elevated serum PTH, hypercalciuria, decreased intestinal calcium absorption, altered vitamin D metabolism, decreased calcium reabsorption, altered membrane- binding, and decreased binding to intracellular calcium-binding proteins. These derangements of systemic and intracellular calcium regulation lead to the overall calcium imbalance best reflected by reduced bone density and bone mineralization.

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Author information

Authors and Affiliations

  1. Division of Nephrology and Hypertension Institute for Nutrition and Cardiovascular Research, Oregon Health Sciences University, Portland, Oregon, USA

    Ramachandra M. Rao, Eric W. Young & David A. McCarron

Authors
  1. Ramachandra M. Rao
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  2. Eric W. Young
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  3. David A. McCarron
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Editor information

Editors and Affiliations

  1. Nagoya University, Nagoya, Japan

    H. Hidaka

  2. Swiss Federal Institute of Technology, Zurich, Switzerland

    E. Carafoli

  3. Baylor College of Medicine, Houston, Texas, USA

    A. R. Means

  4. Mie University School of Medicine, Mie, Japan

    T. Tanaka

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© 1989 Plenum Press, New York

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Rao, R.M., Young, E.W., McCarron, D.A. (1989). Disregulation of Cell Calcium and Calcium-Binding Proteins in Experimental Hypertension. In: Hidaka, H., Carafoli, E., Means, A.R., Tanaka, T. (eds) Calcium Protein Signaling. Advances in Experimental Medicine and Biology, vol 255. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-5679-0_53

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  • DOI: https://doi.org/10.1007/978-1-4684-5679-0_53

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4684-5681-3

  • Online ISBN: 978-1-4684-5679-0

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