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Calbindin-D28 in Mammalian Brain, Retina, and Endocrine Pancreas: Immunohistochemical Comparison with Calretinin

  • R. Pochet
  • F. Blachier
  • W. Malaisse
  • M. Parmentier
  • B. Pasteels
  • V. Pohl
  • A. Résibois
  • J. Rogers
  • A. Roman
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 255)

Abstract

Calbindin 28K and calretinin are very similar calcium binding proteins which are both present in the central nervous system (CNS). They respectively bind 4 and 5 Ca++ ions. We have compared by immunohistochemistry and in situ hybridization their localisation in the brain and the retina. The two proteins are generally expressed in different neurons with a few neurons containing both calcium binding proteins. Calbindin 28K is also present in the endocrine system. We have examined the cellular distribution of calbindin in the pancreatic endocrine cells of chick, rat and human and found variable distribution among the different endocrine cell types. We also describe the presence of calbindin in RINm5F cells, an insulin-producing tumor cell line derived from a radiationinduced rat insulinoma.

Keywords

Endocrine Pancreas Islet Cell Tumor RINm5F Cell Endocrine Cell Type Vanadyl Sulfate 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Plenum Press, New York 1989

Authors and Affiliations

  • R. Pochet
    • 1
  • F. Blachier
    • 1
  • W. Malaisse
    • 2
  • M. Parmentier
    • 3
  • B. Pasteels
    • 1
  • V. Pohl
    • 1
  • A. Résibois
    • 1
  • J. Rogers
    • 4
  • A. Roman
    • 1
  1. 1.Lab of Histology, Fac. of MedicineUniversité Libre de Bruxelles (ULB)Belgium
  2. 2.Lab of Experimental MedicineULBBelgium
  3. 3.I.R.I.B.H.N.ULBBelgium
  4. 4.Physiological LabUniversity of CambridgeUK

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