Stimulation by Inositol Trisphosphate and Tetrakisphosphate of a Protein Phosphatase

  • Jean Zwiller
  • Stuart S. Nakamoto
  • Alton L. Boynton
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 255)


Hormone-receptor coupling often results in the activation of phospholipase C which in turn hydrolyzes phosphatidylinositol 4,5-bisphosphate into two second messengers, 1,2-diacylglycerol (DAG) and inositol 1,4,5-trisphosphate [Ins(1,4,5)]P3. It is well known that DAG remains in the membrane domain and activates protein kinase C while Ins(1,4,5)P3 is soluble and is known to increase the intracellular level of Ca2+. 1,2 Ins(l,4,5)P3 may subsequently be converted to Ins(1,3,4,5)P4 by a soluble inositol trisphosphate 3-Phosphokinase.3 Both Ins(1,4,5)P3 and Ins(1,3,4,5)P4 are substrates of a membrane-bound 5-Phosphomonoesterase being degraded to Ins(1,4)P2 and Ins(1,3,4)P3 respectively.4,5 Ins(1,4,5)P3 and Ins(1,3,4)P3 both mobilize Ca2+,2,6 while the physiological function of Ins(1,3,4,5)P4 is unknown although indirect evidence suggests that it may affect plasma membrane Ca2+ channels.7,8


Phosphatase Activity Protein Phosphatase Inositol Phosphate Inositol Trisphosphate Protein Phosphatase Activity 
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Copyright information

© Plenum Press, New York 1989

Authors and Affiliations

  • Jean Zwiller
    • 1
  • Stuart S. Nakamoto
    • 1
  • Alton L. Boynton
    • 1
  1. 1.Cancer Research CenterUniversity of HawaiiHonoluluUSA

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